Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

2000 • 2,051 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

A Genomic Regulatory Network for Development

2002 • 1,538 citations

A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube

2000 • 1,077 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

2004 • 970 citations

Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos

1993 • 892 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

1998 • 839 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

2008 • 714 citations

Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord

1991 • 698 citations

Gli2, but notGli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

2002 • 671 citations

A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro

1997 • 667 citations

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

1998 • 647 citations

Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

1997 • 625 citations

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

2007 • 602 citations

Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

2001 • 599 citations

Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells

2007 • 582 citations

Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning

2004 • 498 citations

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

1998 • 497 citations

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

1993 • 470 citations

Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling

1998 • 458 citations

Foxj1 transcription factors are master regulators of the motile ciliogenic program

2008 • 454 citations

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system

1991 • 432 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation

1997 • 384 citations

The Cell Surface Membrane Proteins Cdo and Boc Are Components and Targets of the Hedgehog Signaling Pathway and Feedback Network in Mice

2006 • 383 citations

A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube

2001 • 364 citations

Regulation of patched by sonic hedgehog in the developing neural tube.

1996 • 331 citations

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing

1997 • 300 citations

Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning

1996 • 299 citations

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

2008 • 294 citations

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

2008 • 289 citations

Gli1can rescue the in vivo function ofGli2

2001 • 288 citations

HNF-3β as a regulator of floor plate development

1994 • 287 citations

Zebrafishsmoothenedfunctions in ventral neural tube specification and axon tract formation

2001 • 287 citations

Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos.

1993 • 283 citations

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

2007 • 272 citations

Induction of floor plate differentiation by contact-dependent, homeogenetic signals

1993 • 271 citations

Foxa1andFoxa2regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner

2007 • 271 citations

A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

2005 • 270 citations

Genetic analysis of zebrafishgli1andgli2reveals divergent requirements forgligenes in vertebrate development

2003 • 239 citations

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

2008 • 239 citations

Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors

2009 • 231 citations

Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1

2004 • 223 citations

The floor plate: multiple cells, multiple signals

2005 • 214 citations

Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis

2009 • 209 citations

Gas1 extends the range of Hedgehog action by facilitating its signaling

2007 • 207 citations

Integration of growth and specification in chick wing digit-patterning

2008 • 206 citations

Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo

2006 • 203 citations

Expression of a novel aristaless related homeobox gene ‘Arx’ in the vertebrate telencephalon, diencephalon and floor plate

1997 • 177 citations

Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate

1991 • 177 citations

Postgastrulation Smad2- deficient embryos show defects in embryo turning and anterior morphogenesis

1999 • 157 citations

The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

2000 • 142 citations

Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish

2007 • 126 citations

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

2004 • 124 citations

Distinct regulators ofShhtranscription in the floor plate and notochord indicate separate origins for these tissues in the mouse node

2003 • 124 citations

Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification

2003 • 119 citations

Two Distinct Cell Populations in the Floor Plate of the Zebrafish Are Induced by Different Pathways

2000 • 113 citations

Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis

2001 • 112 citations

Restrictions to Floor Plate Induction by hedgehog and Winged-Helix Genes in the Neural Tube of Frog Embryos

1995 • 107 citations

Axial (HNF3β) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter

1997 • 103 citations

Effect of the notochord on proliferation and differentiation in the neural tube of the chick embryo

1989 • 103 citations

Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS.

2000 • 102 citations

Differential patterning of ventral midline cells by axial mesoderm is regulated by BMP7 and chordin

1999 • 102 citations

Characterisation of a SecondpatchedGene in the ZebrafishDanio rerioand the Differential Response ofpatchedGenes to Hedgehog Signalling

1999 • 98 citations

Neuroanatomical distribution of ARX in brain and its localisation in GABAergic neurons

2004 • 98 citations

The relationships between notochord and floor plate in vertebrate development revisited

1998 • 96 citations

Opponent Activities of Shh and BMP Signaling during Floor Plate Induction In Vivo

2002 • 95 citations

Discussion point: Origin and specification of the neural tube floor plate: insights from the chick and zebrafish

2000 • 90 citations

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

2007 • 88 citations

Vertebrate floor-plate specification: variations on common themes

2004 • 86 citations

Distinct modes of floor plate induction in the chick embryo

2003 • 82 citations

Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones

2005 • 75 citations

Fate mapping the avian neural plate with quail/chick chimeras: Origin of prospective median wedge cells

1989 • 67 citations

Expression of Foxp4 in the developing and adult rat forebrain

2008 • 60 citations

Dual origin of the floor plate in the avian embryo

2002 • 52 citations

Expression Analysis of Murine Genes Using <i>In Situ</i> Hybridization With Radioactive and Nonradioactively Labeled RNA Probes

2006 • 46 citations

A temperature-sensitive mutation in thenodal-related genecyclopsreveals that the floor plate is induced during gastrulation in zebrafish

2003 • 46 citations

Discontinuous organization and specification of the lateral floor plate in zebrafish

2006 • 42 citations

A Floor Plate Enhancer of the Zebrafish netrin1 Gene Requires Cyclops (Nodal) Signalling and the Winged Helix Transcription Factor FoxA2

2002 • 39 citations

Similar expression and regulation of Gli2 and Gli3 in the chick limb bud

2000 • 35 citations

Characterization of Foxp2-expressing cells in the developing spinal cord

2009 • 34 citations

Direct action of the Nodal-related signal Cyclops in induction of sonic hedgehog in the ventral midline of the CNS

2000 • 23 citations

Cyclops‐independent floor plate differentiation in zebrafish embryos

2002 • 22 citations

Waiting periods, instructive signals and positional information

2000 • 14 citations