A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

1993 • 1,166 citations

Patterning the Vertebrate Neuraxis

1996 • 1,151 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

1999 • 773 citations

Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

1987 • 651 citations

Requirement for the Homeobox Gene Hb9 in the Consolidation of Motor Neuron Identity

1999 • 605 citations

Morphogens, Compartments, and Pattern: Lessons from Drosophila?

1996 • 559 citations

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

1998 • 497 citations

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

1993 • 470 citations

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

1998 • 448 citations

Transducing Hedgehog: the story so far

1998 • 444 citations

LIM Homeodomain Factors Lhx3 and Lhx4 Assign Subtype Identities for Motor Neurons

1998 • 438 citations

In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins

1999 • 431 citations

Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo

1995 • 376 citations

A Sonic Hedgehog–Independent, Retinoid-Activated Pathway of Neurogenesis in the Ventral Spinal Cord

1999 • 363 citations

Sonic hedgehogRegulates Proliferation and Inhibits Differentiation of CNS Precursor Cells

1999 • 360 citations

Chapter 10 Manipulating Gene Expression with Replication--Competent Retroviruses

1996 • 344 citations

Specification of Motor Neuron Identity by the MNR2 Homeodomain Protein

1998 • 340 citations

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1993 • 326 citations

Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube.

1997 • 323 citations

Comparison of Three Nonviral Transfection Methods for Foreign Gene Expression in Early Chicken Embryosin Ovo

1997 • 316 citations

Control of Drosophila body pattern by the hunchback morphogen gradient

1992 • 294 citations

Transducing the Dpp Morphogen Gradient in the Wing of Drosophila

1999 • 280 citations

The Drosophila Gene brinker Reveals a Novel Mechanism of Dpp Target Gene Regulation

1999 • 262 citations

Gli proteins and Hedgehog signaling: development and cancer

1999 • 249 citations

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes

1999 • 232 citations

Behavior of neuro‐epithelial cells during closure of the neural tube

1966 • 201 citations

Migratory paths of neurons and glia in the embryonic chick spinal cord

1995 • 162 citations

Spatial regulation of the gap gene giant during Drosophila development

1991 • 157 citations

Mediation of Sonic Hedgehog-Induced Expression of COUP-TFII by a Protein Phosphatase

1997 • 149 citations

Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development

1998 • 148 citations

Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord

1998 • 141 citations

Mesodern-inducing factors and mesodermal patterning

1995 • 113 citations

Coelom formation: binary decision of the lateral plate mesoderm is controlled by the ectoderm

1999 • 105 citations

Expression of ptc and gli genes in talpid 3 suggests bifurcation in Shh pathway*

1999 • 98 citations

Activin as a morphogen in Xenopus mesoderm induction

1999 • 84 citations

Nkx2-9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS

1998 • 74 citations

Two distinct mechanisms for differential positioning of gene expression borders involving the Drosophila gap protein giant

1998 • 68 citations

Combinatorial codes in signaling and synergy: lessons from pituitary development

1999 • 66 citations

An anteroposterior Dorsal gradient in theDrosophila embryo

1997 • 60 citations

Gradual Refinement of Activin-Induced Thresholds Requires Protein Synthesis

2000 • 37 citations

Progenitor Dispersal and the Origin of Early Neuronal Phenotypes in the Chick Embryo Spinal Cord

1998 • 19 citations