Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

2000 • 1,019 citations

Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains

1997 • 958 citations

1 Developmental roles and clinical significance of Hedgehog signaling

2003 • 896 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

2000 • 704 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

2002 • 591 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

2001 • 514 citations

Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb

1994 • 465 citations

Indian Hedgehog coordinates endochondral bone growth and morphogenesis via Parathyroid Hormone related-Protein-dependent and -independent pathways

2000 • 449 citations

Manifestation of the Limb Prepattern: Limb Development in the Absence of Sonic Hedgehog Function

2001 • 437 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

Major Problems in Developmental Biology

1966 • 364 citations

Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice

1999 • 335 citations

Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched

2002 • 327 citations

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

1997 • 314 citations

Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb

1996 • 298 citations

Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling

1999 • 293 citations

Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells

2003 • 257 citations

Cell Death in Morphogenesis

1966 • 232 citations

Some distal limb structures develop in mice lacking Sonic hedgehog signaling

2001 • 226 citations

Comparative biological responses to human Sonic, Indian, and Desert hedgehog

2001 • 222 citations

A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling

2000 • 217 citations

The effect of local application of retinoic acid to the anterior margin of the developing chick limb

1983 • 210 citations

The number of polarizing region cells required to specify additional digits in the developing chick wing

1981 • 209 citations

Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth

1997 • 208 citations

Mouse Dispatched homolog1 Is Required for Long-Range, but Not Juxtacrine, Hh Signaling

2002 • 185 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

Cell fate in the chick limb bud and relationship to gene expression

1997 • 167 citations

Vertebrate limb development

1995 • 154 citations

Autoregulation ofShhexpression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development

2000 • 110 citations

Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud

1994 • 97 citations

Ptc1 and Ptc2 Transcripts Provide Distinct Readouts of Hedgehog Signaling Activity during Chick Embryogenesis

2001 • 85 citations

GFPcreFusion Vectors with Enhanced Expression

1999 • 55 citations

Fate map of mouse ventral limb ectoderm and the apical ectodermal ridge

2003 • 44 citations

Dose dependency ofDisp1and genetic interaction betweenDisp1and other hedgehog signaling components in the mouse

2004 • 28 citations