Expression of a novel aristaless related homeobox gene ‘Arx’ in the vertebrate telencephalon, diencephalon and floor plate

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

1977 • 2,408 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes

1984 • 1,638 citations

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6

1994 • 1,346 citations

Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

1994 • 1,311 citations

Pax-6, a murine paired box gene, is expressed in the developing CNS

1991 • 1,226 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

In situ Hybridization

1994 • 875 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Nested expression domains of four homeobox genes in developing rostral brain

1992 • 794 citations

Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization

1993 • 777 citations

Midbrain development induced by FGF8 in the chick embryo

1996 • 734 citations

Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord

1991 • 698 citations

Mouse Otx2 functions in the formation and patterning of rostral head.

1995 • 690 citations

Forebrain and midbrain regions are deleted in Otx2−/− mutants due to a defective anterior neuroectoderm specification during gastrulation

1995 • 683 citations

Chemotropic guidance of developing axons in the mammalian central nervous system

1988 • 681 citations

Longitudinal organization of the anterior neural plate and neural tube

1995 • 647 citations

A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.

1993 • 617 citations

Combinatorial expression of three zebrafish genes related to distal- less: part of a homeobox gene code for the head

1994 • 607 citations

Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries

1993 • 570 citations

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres

1995 • 569 citations

Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube

1995 • 542 citations

The Embryonic Vertebrate Forebrain: the Prosomeric Model

1994 • 530 citations

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain

1996 • 502 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

1992 • 472 citations

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

1993 • 470 citations

Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development

1996 • 440 citations

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system

1991 • 432 citations

Telencephalon-restricted expression of BF-1, a new member of the HNF-3/ fork head gene family, in the developing rat brain

1992 • 417 citations

Guidebook to the homeobox genes

1994 • 399 citations

Segmental organization of embryonic diencephalon

1993 • 395 citations

Distal-less encodes a homoeodomain protein required for limb development in Drosophila

1989 • 389 citations

Developmental expression of a novel murine homeobox gene (Chx10): Evidence for roles in determination of the neuroretina and inner nuclear layer

1994 • 379 citations

The emergence and evolution of mammalian neocortex

1995 • 376 citations

Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain

1995 • 337 citations

Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum

1994 • 310 citations

Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development

1996 • 291 citations

HNF-3β as a regulator of floor plate development

1994 • 287 citations

A mouse gene related to Distal-less shows a restricted expression in the developing forebrain

1991 • 273 citations

Guidebook to the Homeobox Genes

1995 • 270 citations

Expression of two zebrafish orthodenticle-related genes in the embryonic brain

1994 • 227 citations

Orientation of commissural axons in vitro in response to a floor plate-derived chemoattractant

1990 • 227 citations

From fly head to mammalian forebrain: the story of otd and Otx

1994 • 216 citations

DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain

1994 • 215 citations

Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain

1994 • 213 citations

Specification of limb development in the Drosophila embryo by positional cues from segmentation genes

1990 • 211 citations

The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos

1993 • 209 citations

Expression of winged helix genes, BF‐1 and BF‐2, define adjacent domains within the developing forebrain and retina

1994 • 208 citations

Pax: Gene regulators in the developing nervous system

1993 • 195 citations

Essential Developmental Biology

1993 • 188 citations

Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and drosophila

1994 • 181 citations

Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate

1991 • 177 citations

Role of the floor plate in axonal patterning in the zebrafish CNS

1992 • 169 citations

Pancreatic beta cells express a diverse set of homeobox genes.

1994 • 156 citations

Emx and Otx homeobox genes in the developing mouse brain

1993 • 139 citations

Different spatio-temporal expressions of three otx homeoprotein transcripts during zebrafish embryogenesis

1994 • 135 citations

Initial Organization of Neurons and Tracts in the Embryonic Mouse Fore- and Midbrain

1996 • 124 citations

Ectopic induction and reorganization of Wnt-1 expression in quail/chick chimeras

1994 • 120 citations

The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme

1991 • 106 citations

A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes

1995 • 103 citations

Guidance of cerebellofugal axons in the rat embryo: Directed growth toward the floor plate and subsequent elongation along the longitudinal axis

1995 • 100 citations

Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes.

1993 • 89 citations

A Chicken Homeobox Gene Related to Drosophila paired Is Predominantly Expressed in the Developing Limb

1993 • 84 citations

Conserved classes of homeodomains in Schistosoma mansoni, an early bilateral metazoan

1992 • 71 citations

Floor plate chemoattracts crossed axons and chemorepels uncrossed axons in the vertebrate brain

1995 • 71 citations

Members of the Dlx‐and NKx2‐gene families are regionally expressed in the developing forebrain

1993 • 63 citations

The brain organization

1996 • 20 citations