Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

1999 • 1,682 citations

Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein

1998 • 1,565 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

Activating Smoothened mutations in sporadic basal-cell carcinoma

1998 • 1,327 citations

Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog

1999 • 1,313 citations

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

1995 • 1,130 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

1998 • 868 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Hedgehog signals regulate multiple aspects of gastrointestinal development

2000 • 821 citations

A molecular pathway determining left-right asymmetry in chick embryogenesis

1995 • 781 citations

Sonic hedgehog regulates growth and morphogenesis of the tooth

2000 • 778 citations

Sonic hedgehog signaling is essential for hair development

1998 • 742 citations

Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb

1995 • 719 citations

Sonic hedgehog is essential to foregut development

1998 • 685 citations

Sertoli cell signaling by Desert hedgehog regulates the male germline

1996 • 664 citations

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

1999 • 646 citations

Sonic hedgehog regulates branching morphogenesis in the mammalian lung

1998 • 631 citations

Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog

1994 • 594 citations

The world according to bedgebog

1997 • 549 citations

Relationship between asymmetric nodal expression and the direction of embryonic turning

1996 • 547 citations

lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal

1998 • 539 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

Pitx2 determines left–right asymmetry of internal organs in vertebrates

1998 • 512 citations

Essential Role forSonic hedgehogduring Hair Follicle Morphogenesis

1999 • 489 citations

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds

1999 • 455 citations

Indian Hedgehog coordinates endochondral bone growth and morphogenesis via Parathyroid Hormone related-Protein-dependent and -independent pathways

2000 • 449 citations

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

1997 • 443 citations

Regulation of pancreas development by hedgehog signaling

2000 • 415 citations

Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry

1998 • 371 citations

Sonic hedgehogRegulates Proliferation and Inhibits Differentiation of CNS Precursor Cells

1999 • 360 citations

Targeted disruption of the Wnt2 gene results in placentation defects

1996 • 357 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Pitx2 Participates in the Late Phase of the Pathway Controlling Left-Right Asymmetry

1998 • 330 citations

Schwann Cell–Derived Desert Hedgehog Controls the Development of Peripheral Nerve Sheaths

1999 • 324 citations

Mechanisms of Left–Right Determination in Vertebrates

2000 • 314 citations

Differences in Left-Right Axis Pathways in Mouse and Chick: Functions of FGF8 and SHH

1999 • 307 citations

Analysis of Epithelial–Mesenchymal Interactions in the Initial Morphogenesis of the Mammalian Tooth

1998 • 305 citations

Wnt signaling and the activation of myogenesis in mammals

1999 • 304 citations

The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity

2000 • 297 citations

Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling

1999 • 293 citations

Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression.

1991 • 286 citations

Characterization of two patched receptors for the vertebrate hedgehog protein family

1998 • 281 citations

Sonic hedgehog controls epaxial muscle determination through Myf5 activation

1999 • 269 citations

Multiple left-right asymmetry defects in Shh ^−/− mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1

1999 • 263 citations

Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog

1999 • 252 citations

Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation

1999 • 245 citations

Two closely‐related left‐right asymmetrically expressed genes, lefty‐1 and lefty‐2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos

1997 • 245 citations

Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube.

1993 • 242 citations

The EGF-CFC gene family in vertebrate development

2000 • 221 citations

Regulation of left-right patterning in mice by growth/differentiation factor-1

2000 • 216 citations

Conserved and divergent mechanisms in left–right axis formation

2000 • 192 citations

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

2001 • 191 citations

A duplicated zone of polarizing activity in polydactylous mouse mutants.

1995 • 189 citations

Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages

1998 • 189 citations

Control of somite patterning by Sonic hedgehog and its downstream signal response genes

1998 • 183 citations

Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development

2000 • 175 citations

A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ

2000 • 150 citations

The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

2000 • 142 citations

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein

2000 • 141 citations

A role of the cryptic gene in the correct establishment of the left–right axis

1999 • 133 citations

Posttranscriptional Regulation of Smoothened Is Part of a Self-Correcting Mechanism in the Hedgehog Signaling System

2000 • 108 citations

Alteration of limb and brain patterning in early mouse embryos by ultrasound-guided injection of Shh-expressing cells

1998 • 106 citations

5 Multiple Tissue Interactions and Signal Transduction Pathways Control Somite Myogenesis

1999 • 98 citations

In Vivo Regulation of Somite Differentiation and Proliferation by Sonic Hedgehog

1999 • 95 citations

Vertebrate heart development

1996 • 77 citations

3 Sclerotome Induction and Differentiation

1999 • 70 citations

The role of positive and negative signals in somite patterning

1996 • 67 citations

Cloning of a Mouse Smoothened cDNA and Expression Patterns of Hedgehog Signalling Molecules during Chondrogenesis and Cartilage Differentiation in Clonal Mouse EC Cells, ATDC5

1997 • 67 citations

The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development.

1997 • 53 citations

Mediolateral patterning of somites: multiple axial signals, including Sonic hedgehog, regulate Nkx-3.1 expression

1998 • 49 citations

Untitled

1997 • 44 citations

Sonic Hedgehog Promotes Neuronal Differentiation of Murine Spinal Cord Precursors and Collaborates with Neurotrophin 3 to Induce Islet-1

1999 • 43 citations

Hedgehog Signal Transduction in the Posterior Compartment of the Drosophila Wing Imaginal Disc

2000 • 43 citations