Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

1997 • 1,440 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

Defective Cholesterol Biosynthesis Associated with the Smith-Lemli-Opitz Syndrome

1994 • 802 citations

Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

1996 • 646 citations

Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

1992 • 638 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

1993 • 470 citations

Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo

1995 • 376 citations

Patterning of the embryonic forebrain

1998 • 221 citations

Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources

1968 • 153 citations

Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in hepatoma tissue culture cells by pure cholesterol and several cholesterol derivatives. Evidence supporting two distinct mechanisms.20l.

1976 • 149 citations

Multiple roles of cholesterol in hedgehog protein biogenesis and signaling.

1997 • 122 citations

Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos

1994 • 111 citations

Glycoprotein 330/Low Density Lipoprotein Receptor-related Protein-2 Mediates Endocytosis of Low Density Lipoproteins via Interaction with Apolipoprotein B100

1995 • 103 citations

Progesterone Inhibits Cholesterol Biosynthesis in Cultured Cells

1996 • 94 citations

3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured fibroblasts from patients with mevalonate kinase deficiency: differential response to lipid supplied by fetal bovine serum in tissue culture medium.

1990 • 61 citations

Inhibition of Cholesterol Synthesis and Cell Growth by 24(R, S),25-Iminolanosterol and Triparanol in Cultured Rat Hepatoma Cells

1989 • 49 citations

The effects of BM 15.766, an inhibitor of 7-dehydrocholesterol δ7-reductase∗, on cholesterol biosynthesis in primary rat hepatocytes

1986 • 42 citations

Effects of drugs on cholesterol esterification in normal and Niemann-Pick type C fibroblasts: AY-9944, other cationic amphiphilic drugs and DMSO

1991 • 22 citations

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1964 • 18 citations

Cholesterol homeostasis is modulated by amphiphiles at transcriptional and post-transcriptional loci

1996 • 17 citations