Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

2000 • 2,051 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

2000 • 1,299 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

1999 • 772 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

2000 • 704 citations

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

1999 • 703 citations

Gli2, but notGli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

2002 • 671 citations

A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro

1997 • 667 citations

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

1997 • 658 citations

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

1997 • 606 citations

Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

2001 • 599 citations

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

2002 • 591 citations

Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3

1999 • 528 citations

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

1998 • 497 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

1998 • 448 citations

Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

2000 • 394 citations

Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

2002 • 381 citations

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

2001 • 368 citations

A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube

2001 • 364 citations

A Sonic Hedgehog–Independent, Retinoid-Activated Pathway of Neurogenesis in the Ventral Spinal Cord

1999 • 363 citations

The Whereabouts of a Morphogen: Direct Evidence for Short- and Graded Long-Range Activity of Hedgehog Signaling Peptides

2001 • 288 citations

Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles

2002 • 287 citations

Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1

1997 • 275 citations

Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling

2002 • 272 citations

Gli proteins and Hedgehog signaling: development and cancer

1999 • 249 citations

Gli3 is required for Emx gene expression during dorsal telencephalon development

1999 • 231 citations

Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities

2000 • 217 citations

Mouse GLI3 Regulates Fgf8 Expression and Apoptosis in the Developing Neural Tube, Face, and Limb Bud

2002 • 204 citations

Dorsoventral Patterning of the Telencephalon Is Disrupted in the Mouse Mutant extra-toesJ

2000 • 200 citations

GLI 3 mutations in human disorders mimic Drosophila Cubitus interruptus protein functions and localization

1999 • 173 citations

A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo

2002 • 172 citations

An absolute requirement for Cubitus interruptus in Hedgehog signaling.

2001 • 152 citations

The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

2000 • 142 citations

Sonic hedgehog synergizes with the extracellular matrix protein Vitronectin to induce spinal motor neuron differentiation

2000 • 89 citations

High-resolution mapping of the Gli3 mutation Extra-toesJ reveals a 51.5-kb deletion

2002 • 85 citations

The Xt J allele generates a Gli 3 fusion transcript

1998 • 59 citations

Distinct and regulated activities of human Gli proteins in Drosophila

1999 • 58 citations

Vitronectin is expressed in the ventral region of the neural tube and promotes the differentiation of motor neurons

1997 • 57 citations

The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development.

1997 • 53 citations

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1997 • 44 citations