A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis

1977 • 750 citations

Initiation of mammalian protein synthesis

1977 • 341 citations

Initiation of Eukaryotic Protein Synthesis: [Met-tRNAf.40S Ribosome] Initiation Complex Catalysed by Purified Initiation Factors in the Absence of mRNA

1973 • 306 citations

The Regulation of Initiation of Mammalian Protein Synthesis

1981 • 266 citations

Control of globin synthesis: The role of heme

1972 • 257 citations

[29] Chromatography of proteins on hydroxyapatite

1971 • 179 citations

Nucleotide regulation of a eukaryotic protein synthesis initiation complex

1975 • 143 citations

Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2

1982 • 141 citations

Mechanism of polypeptide chain initiation in eukaryotes and its control by phosphorylation of the alpha subunit of initiation factor 2.

1982 • 134 citations

Interferon, double-stranded RNA, and protein phosphorylation. Characteristics of a double-stranded RNA-activated protein kinase system partially purified from interferon treated Ehrlich ascites tumor cells.

1978 • 128 citations

Purification and characterization of initiation factor IF-E2 from rabbit reticulocytes.

1976 • 127 citations

[18] Chromatography of proteins on hydroxyapatite

1973 • 121 citations

Purification and Characterization of a Protein Factor that Reverses the Inhibition of Protein Synthesis by the Heme‐Regulated Translational Inhibitor in Rabbit Reticulocyte Lysates

1979 • 107 citations

Binding and release of eukaryotic initiation factor eIF-2 and GTP during protein synthesis initiation.

1978 • 107 citations

Comprehensive Biochemistry

1980 • 99 citations

Binding of MET-TRNAf and GTP to homogeneous initiation factor MP

1975 • 93 citations

The Ribosome Cycle in Mammalian Protein Synthesis

1973 • 93 citations

Initiation of Protein Synthesis in Ehrlich Ascites Tumour Cells

1975 • 87 citations

The effects of amino acid starvation on regulation of polypeptide chain initiation in Ehrlich ascites tumor cells.

1980 • 86 citations

Regulation of protein synthesis in rabbit reticulocyte lysates: Additional initiation factor required for formation of ternary complex (eIF-2·GTP·Met-tRNA _f ) and demonstration of inhibitory effect of heme-regulated protein kinase

1979 • 86 citations

Protein synthesis in rabbit reticulocytes: mechanism of protein synthesis inhibition by heme-regulated inhibitor.

1979 • 74 citations

Mode of action of the heme-controlled translational inhibitor: relationship of eukaryotic initiation factor 2-stimulating protein to translation restoring factor.

1981 • 67 citations

High-performance liquid chromatographic assay for identification and quantitation of nucleotides in lymphocytes and malignant lymphoblasts

1982 • 66 citations

Binding of Met-tRNA_f to native and derived 40S ribosomal subunits

1975 • 63 citations

Modulation of Protein Function

1979 • 62 citations

Initiation of eukaryotic protein synthesis

1981 • 60 citations

Control of protein synthesis by hemin. Isolation and characterization of a supernatant factor from rabbit reticulocyte lysate

1976 • 50 citations

Inhibition of cell division by interferon: Changes in cell cycle characteristics and in morphology of ehrlich ascites tumour cells in culture

1981 • 47 citations

Differential phosphorylation of soluble versus ribosome-bound eukaryotic initiation factor 2 in the Ehrlich ascites tumor cell.

1982 • 47 citations

Regulation of Protein Synthesis in Rabbit Reticulocyte Lysates. Phosphorylation of eIF-2 Does Not Inhibit Its Capacity to Recycle

1980 • 41 citations

Characterization of purified double-stranded RNA-activated eIF-2 alpha kinase from rabbit reticulocytes.

1981 • 39 citations

Protein synthesis in rabbit reticulocytes: characteristics of a postribosomal supernatant factor that reverses inhibition of protein synthesis in heme-deficient lysates and inhibition of ternary complex (Met-tRNAfMet.eIF-2.GTP) formation by heme-regulated inhibitor.

1979 • 35 citations

Induction by Interferon in HeLa Cells of a Protein Kinase Activated by Double-Stranded RNA

1979 • 33 citations

Systematic variations in the content of the purine nucleotides in the steady-state perfused rat heart. Evidence for the existence of controlled storage and release of adenine nucleotides

1978 • 31 citations

[39] Translational systems prepared from the Erhlich Ascites Tumor Cell

1983 • 21 citations

Roles of Eukaryotic Initiation Factor 2 Ancillary Factors in the Regulation of Eukaryotic Protein Synthesis Initiation

1982 • 11 citations

[23] Assay of the binding of the ternary complex Met-tRNAf·eIF-2·GTP to the 40 S ribosomal subunit by sucrose gradient and CsCl gradient analysis

1979 • 10 citations

Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2: Further evidence for a common mechanism of inhibition of protein synthesis

1982 • 9 citations

Regulation of protein synthesis in Ehrlich ascites tumour cells in culture

1980 • 6 citations