The role of p53 in human cancer.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities

1998 • 2,061 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

p53 function and dysfunction

1992 • 1,918 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Soft-Tissue Sarcomas, Breast Cancer, and Other Neoplasms

1969 • 1,437 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

The p53 pathway

1999 • 1,322 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

A cancer family syndrome in twenty-four kindreds.

1988 • 1,274 citations

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 • 1,269 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1997 • 945 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome

1999 • 908 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Heterozygous Germline Mutations in the p53 Homolog p63 Are the Cause of EEC Syndrome

1999 • 697 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies

1996 • 666 citations

Twenty years of p53 research: structural and functional aspects of the p53 protein

1999 • 659 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

Multiple Primary Cancers in Families With Li-Fraumeni Syndrome

1998 • 548 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

The ubiquitin system

1997 • 541 citations

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

1998 • 535 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

p53 in growth control and neoplasia

1996 • 488 citations

Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families

1994 • 479 citations

Genetic determinants of p53-induced apoptosis and growth arrest.

1996 • 472 citations

Statement of the American Society of Clinical Oncology: genetic testing for cancer susceptibility, Adopted on February 20, 1996.

1996 • 466 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

A simple p53 functional assay for screening cell lines, blood, and tumors.

1995 • 447 citations

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1998 • 445 citations

Tumors associated with p53 germline mutations: a synopsis of 91 families.

1997 • 409 citations

Rhabdomyosarcoma in Children: Epidemiologic Study and Identification of a Familial Caneer Syndrome

1969 • 398 citations

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

1989 • 383 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

Cooperative tumorigenic effects of germline mutations in Rb and p53

1994 • 374 citations

Li-Fraumeni syndrome – a molecular and clinical review

1997 • 362 citations

Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins

1989 • 358 citations

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1995 • 334 citations

High-Resolution Structure of the Oligomerization Domain of p53 by Multidimensional NMR

1994 • 300 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.

1994 • 295 citations

A novel protein with strong homology to the tumor suppressor p53

1997 • 282 citations

Cytoplasmic Sequestration of Wild-Type p53 Protein Impairs the G₁ Checkpoint after DNA Damage

1996 • 274 citations

Follow-up study of twenty-four families with Li-Fraumeni syndrome.

1991 • 274 citations

Are There Low-Penetrance TP53 Alleles? Evidence from Childhood Adrenocortical Tumors

1999 • 261 citations

Solution structure of the tetrameric minimum transforming domain of p53

1994 • 260 citations

Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families.

1997 • 260 citations

Oxidative damage in chemical teratogenesis

1997 • 255 citations

Inherited p53 gene mutations in breast cancer.

1992 • 255 citations

A teratologic suppressor role for p53 in benzo(a)pyrene–treated transgenic p53-deficient mice

1995 • 250 citations

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

1995 • 233 citations

Dial 9-1-1 for p53: Mechanisms of p53 Activation by Cellular Stress

2000 • 223 citations

High Frequency of Germline p53 Mutations in Childhood Adrenocortical Cancer

1994 • 219 citations

Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma.

1995 • 217 citations

Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.

1995 • 198 citations

Cancer phenotype correlates with constitutional TP53 genotype in families with the Li–Fraumeni syndrome

1998 • 197 citations

Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma.

1994 • 197 citations

Regulation of Mdm2-Directed Degradation by the C Terminus of p53

1998 • 194 citations

Screening for germ line TP53 mutations in breast cancer patients.

1992 • 190 citations

Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin.

1995 • 181 citations

The p53 gene family

1999 • 174 citations

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

1997 • 171 citations

A Phase I Study of Adenovirus-Mediated Wild-Type p53 Gene Transfer in Patients with Advanced Non-Small Cell Lung Cancer

1998 • 167 citations

Adenovirus-mediated wild-type p53 gene transfer as a surgical adjuvant in advanced head and neck cancers.

1999 • 151 citations

MDM2 and MDMX bind and stabilize the p53-related protein p73

1999 • 132 citations

p53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy

1997 • 122 citations

p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent

1999 • 121 citations

Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53.

1993 • 118 citations

Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice.

1994 • 117 citations

A Second p53-Related Protein, p73L, with High Homology to p73

1998 • 115 citations

High Incidence of Lung, Bone, and Lymphoid Tumors in Transgenic Mice Overexpressing Mutant Alleles of the p53 Oncogene

1989 • 109 citations

Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer.

1996 • 99 citations

The Li–Fraumeni syndrome

2002 • 98 citations

Database and software for the analysis of mutations in the human p53 gene.

1994 • 82 citations

p63 and p73: old members of a new family

2000 • 68 citations

The effects of combining ionizing radiation and adenoviral p53 therapy in nasopharyngeal carcinoma

1999 • 68 citations

Adenovirus-mediated p53 gene delivery potentiates the radiation-induced growth inhibition of experimental brain tumors.

1998 • 53 citations

Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion.

1996 • 47 citations

A Novel Germ-Line Mutation in the Noncoding Region of the p53 Gene in a Li-Fraumeni Family

1998 • 45 citations

Statement of the American Society of Human Genetics on genetic testing for breast and ovarian cancer predisposition.

1994 • 41 citations

Predominantly tumor-limited expression of a mutant allele in a Japanese family carrying a germline p53 mutation.

1994 • 40 citations

Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma

1998 • 38 citations

Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas.

1999 • 38 citations

Choroid plexus tumors in the breast cancer–sarcoma syndrome

1990 • 37 citations

Mutation and expression analysis of thep73 gene in prostate cancer

1999 • 37 citations

p53 compound heterozygosity in a severely affected child with Li-Fraumeni Syndrome

1999 • 35 citations

Functions of the p53 Protein in Growth Regulation and Tumor Suppression

1994 • 32 citations

Genetic transmission of susceptibility to cancer in families of children with soft tissue sarcomas

1996 • 22 citations

Two types of dose-response in Arabidopsis thaliana after the action of nitrosamines

1971 • 21 citations

A novel deletion within exon 6 of TP53 in a family with Li-Fraumeni-like syndrome, and LOH in a benign lesion from a mutation carrier

1996 • 13 citations

The p73 gene is not mutated in oligodendrogliomas which frequently have a deleted region at chromosome 1p36.3.

2000 • 12 citations

Deleted Work

1955 • 0 citations