Regulating expression and function of G-protein-linked receptors

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits

1991 • 1,076 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Structural determinants for activation of the α-subunit of a heterotrimeric G protein

1994 • 636 citations

New roles for G-protein (βγ-dimers in transmembrane signalling

1993 • 633 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1.

1993 • 533 citations

An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro.

1991 • 484 citations

In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

1992 • 470 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

G protein—coupled receptor kinases

1993 • 434 citations

The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway

1987 • 431 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Inhibition of Adenylyl Cyclase by G _iα

1993 • 402 citations

Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins

1993 • 393 citations

Different β-subunits determine G-protein interaction with transmembrane receptors

1992 • 390 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits

1988 • 306 citations

A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells.

1991 • 304 citations

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.

1991 • 293 citations

Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells

1995 • 288 citations

Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor

1989 • 271 citations

Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels.

1988 • 268 citations

Agonist-induced Destabilization of β-Adrenergic Receptor mRNA

1989 • 267 citations

Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids.

1988 • 261 citations

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.

1983 • 247 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src

1993 • 230 citations

Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.

1986 • 221 citations

The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities.

1991 • 218 citations

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

1991 • 214 citations

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

1995 • 211 citations

The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis.

1994 • 210 citations

Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice.

1994 • 201 citations

cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.

1989 • 200 citations

Regulation of beta-adrenergic receptors by "permissive" hormones: glucocorticoids increase steady-state levels of receptor mRNA.

1988 • 196 citations

A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif

1988 • 187 citations

G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes

1995 • 185 citations

A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor.

1994 • 182 citations

Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF-2 smooth muscle cells.

1991 • 178 citations

Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.

1994 • 167 citations

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.

1993 • 159 citations

AU RNA-binding factors differ in their binding specificities and affinities.

1992 • 157 citations

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells.

1991 • 156 citations

Transmembrane Receptors and Intracellular Pathways that Control Cell Proliferation

1992 • 151 citations

The G-Protein Family and Their Interaction with Receptors*

1989 • 149 citations

Retinal rods and cones have distinct G protein beta and gamma subunits.

1992 • 147 citations

Antisense oligodeoxynucleotides to Gs protein α-subunit sequence accelerate differentiation of fibroblasts to adipocytes

1992 • 146 citations

Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf.

1990 • 145 citations

From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors

1992 • 143 citations

Cross-regulation between G-protein-mediated pathways. Stimulation of adenylyl cyclase increases expression of the inhibitory G-protein, Gi alpha 2.

1990 • 140 citations

Agonist Regulation of Gene Expression of Adrenergic Receptors and G Proteins

1993 • 125 citations

Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA.

1994 • 125 citations

Induction of Gα _iI2 -Specific Antisense RNA in Vivo Inhibits Neonatal Growth

1993 • 123 citations

Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells.

1991 • 117 citations

Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts.

1994 • 113 citations

Regulation of proto-oncogene mRNA stability

1992 • 111 citations

Beta-adrenergic agonists that down-regulate receptor mRNA up-regulate a M(r) 35,000 protein(s) that selectively binds to beta-adrenergic receptor mRNAs.

1992 • 111 citations

Thyroid hormones transcriptionally regulate the beta 1-adrenergic receptor gene in cultured ventricular myocytes

1991 • 111 citations

Regulation of receptor expression by agonists: transcriptional and post-transcriptional controls

1991 • 103 citations

Genetic analysis of beta-adrenergic receptor internalization and down-regulation.

1985 • 102 citations

Cross-talk between tyrosine kinase and G-protein-linked receptors. Phosphorylation of beta 2-adrenergic receptors in response to insulin.

1992 • 102 citations

Regulation of the Differentiation of Teratocarcinoma Cells into Primitive Endoderm by Gβ _i2

1992 • 99 citations

The β-Adrenergic Receptor Is a Substrate for the Insulin Receptor Tyrosine Kinase

1996 • 98 citations

Isoprenylation of C-terminal cysteine in a G-protein gamma subunit.

1990 • 95 citations

Liver cell adenylate cyclase and beta-adrenergic receptors. Increased beta-adrenergic receptor number and responsiveness in the hypothyroid rat.

1980 • 94 citations

Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors.

1993 • 90 citations

Agonist Regulation of β-Adrenergic Receptor mRNA

1989 • 89 citations

Focal adhesion-associated proteins p125FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells.

1994 • 88 citations

Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-gamma. An alternative mechanism for cholinergic-induced phosphoinositide breakdown.

1993 • 87 citations

Catecholamine Receptors: Structure, Function, and Regulation

1993 • 83 citations

Cross-regulation between G-protein-coupled receptors. Activation of beta 2-adrenergic receptors increases alpha 1-adrenergic receptor mRNA levels

1991 • 80 citations

Evidence that glucocorticoid response elements in the 5′-noncoding region of the hamster β2-adrenergic receptor gene are obligate for glucocoticoid regulation of receptor mRNA levels

1988 • 79 citations

The Angiotensin II AT1 Receptor Is Tyrosine and Serine Phosphorylated and can Serve as a Substrate for the SRC Family of Tyrosine Kinases

1994 • 77 citations

Cross-regulation between G-protein-mediated pathways. Activation of the inhibitory pathway of adenylylcylclase increases the expression of beta 2-adrenergic receptors

1991 • 77 citations

Mutations in G protein-linked receptors: Novel insights on disease

1993 • 73 citations

Phosphorylation of Tyrosyl Residues 350/354 of the β-Adrenergic Receptor Is Obligatory for Counterregulatory Effects of Insulin

1995 • 72 citations

Transcriptional down-regulation by insulin of the beta 3-adrenergic receptor expression in 3T3-F442A adipocytes: a mechanism for repressing the cAMP signaling pathway.

1994 • 69 citations

Endothelins stimulate tyrosine phosphorylation and activity of p42/mitogen-activated protein kinase in astrocytes

1993 • 68 citations

Platelet Shape Change Induced by Thrombin Receptor Activation

1995 • 64 citations

Structure and Regulation of G Protein-Coupled Receptors: The β2-Adrenergic Receptor as a Model

1991 • 64 citations

High-efficiency expression of mammalian β-adrenergic receptors in baculovirus-infected insect cells

1989 • 62 citations

Regulation of cellular signal transduction pathways by desensitization and amplification

1994 • 62 citations

The Mr 35,000 β-Adrenergic Receptor mRNA-binding Protein Binds Transcripts of G-protein-linked Receptors Which Undergo Agonist-induced Destabilization

1995 • 59 citations

Progesterone transcriptionally regulates the beta 2-adrenergic receptor gene in pregnant rat myometrium.

1992 • 59 citations

The M(r) 35,000 beta-adrenergic receptor mRNA-binding protein induced by agonists requires both an AUUUA pentamer and U-rich domains for RNA recognition.

1993 • 59 citations

Phosphorylation of Gi alpha 2 attenuates inhibitory adenylyl cyclase in neuroblastoma/glioma hybrid (NG-108-15) cells.

1994 • 57 citations

Identification of an activity that interacts with the 3'-untranslated region of c-myc mRNA and the role of its target sequence in mediating rapid mRNA degradation.

1994 • 56 citations

Expression of functional G protein beta gamma dimers of defined subunit composition using a baculovirus expression system.

1992 • 56 citations

Beta 1- and beta 2-adrenergic receptor expression in differentiating 3T3-L1 cells. Independent regulation at the level of mRNA.

1990 • 55 citations

Analysis of human and rodent beta 3-adrenergic receptor messenger ribonucleic acids.

1994 • 53 citations

Crystallization and Preliminary Crystallographic Studies of Giα1 and Mutants of Giα1 in the GTP and GDP-bound States

1994 • 52 citations

Glucocorticoids down-regulate β1-adrenergic-receptor expression by suppressing transcription of the receptor gene

1994 • 47 citations

TISSUE-SPECIFIC REGULATION OF α_1B, β₁AND β₂-ADRENERGIC RECEPTOR mRNAs BY THYROID STATE IN THE RAT

1991 • 47 citations

Differential down-regulation of β1- and β2-adrenergic receptor mRNA in C6 glioma cells

1990 • 42 citations

AUUUA motifs are dispensable for rapid degradation of the mouse c-myc RNA.

1990 • 42 citations

Human bradykinin B2 receptors isolated by receptor-specific monoclonal antibodies are tyrosine phosphorylated.

1993 • 37 citations

Physiological regulation at the level of mRNA: analysis of steady-state levels of specific mRNAs by DNA-excess solution hybridization

1989 • 33 citations

Prolonged activation of protein kinase C induces transcription and expression of the alpha 1B adrenergic receptor gene in DDT1 MF-2 cells.

1993 • 28 citations

Cross-regulation between G-protein-mediated pathways. Acute activation of the inhibitory pathway of adenylylcyclase reduces beta 2-adrenergic receptor phosphorylation and increases beta-adrenergic responsiveness.

1992 • 28 citations

Integration of transmembrane signaling

1993 • 27 citations

Age-dependent changes in beta-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats.

1995 • 27 citations

Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts

1994 • 26 citations

Quantification of -Adrenoceptors and -Adrenoceptor Kinase on Protein and mRNA Levels in Heart Failure

1994 • 25 citations

Regulation of mouse beta 3-adrenergic receptor gene expression and mRNA splice variants in adipocytes

1995 • 23 citations

Prolonged Activation of α1 Adrenoceptors Induces Downregulation of Protein Kinase C in Vascular Smooth Muscle

1992 • 18 citations

Transcriptional and posttranscriptional regulation of hepatic β₂‐adrenergic receptor gene expression during development

1993 • 13 citations

Association of hepatic β₂‐adrenergic receptor gene transcript destabilization during postnatal development in the sprague‐dawley rat with a M_r 85,000 protein that binds selectively to the β₂‐adrenergic receptor mRNA 3′‐untranslated region

1995 • 10 citations

Structure and functional analysis of G protein-coupled receptors and potential diagnostic ligands.

1995 • 10 citations