Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1.

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

Gene Activity in Early Development

1968 • 1,725 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma

1983 • 732 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

RNA-binding proteins as developmental regulators.

1989 • 679 citations

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

1989 • 561 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

Extreme instability of myc mRNA in normal and transformed human cells.

1984 • 522 citations

Identification of an AUUUA-Specific Messenger RNA Binding Protein

1989 • 515 citations

An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro.

1991 • 484 citations

Sequence-Specific Binding of Transfer RNA by Glyceraldehyde-3-Phosphate Dehydrogenase

1993 • 461 citations

Poly(A) signals

1991 • 438 citations

Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization

1989 • 434 citations

A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: Domain structure and expression

1986 • 389 citations

Sequence-specific RNA binding by the HIV-1 Rev protein

1989 • 384 citations

The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro.

1989 • 373 citations

Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences

1989 • 347 citations

Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system.

1988 • 324 citations

Rapid Cytoplasmic Turnover of c-myc mRNA: Requirement of the 3′ Untranslated Sequences

1987 • 302 citations

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.

1991 • 293 citations

REGULATED mRNA STABILITY

1990 • 279 citations

A 32-kilodalton protein binds to AU-rich domains in the 3' untranslated regions of rapidly degraded mRNAs.

1991 • 268 citations

Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.

1989 • 236 citations

Mutations affecting stability and deadenylation of the yeast MFA2 transcript.

1992 • 228 citations

GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor

1988 • 227 citations

Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast

1992 • 212 citations

Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences.

1993 • 208 citations

Transcription-Dependent and Transcription-Independent Nuclear Transport of hnRNP Proteins

1991 • 184 citations

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.

1992 • 181 citations

Regulation of c-myc mRNA Stability In Vitro by a Labile Destabilizer with an Essential Nucleic Acid Component

1989 • 172 citations

Regulation of mRNA turnover in eukaryotic cells.

1991 • 171 citations

A binding consensus: RNA-protein interactions in splicing, snRNPs, and sex

1989 • 162 citations

AU RNA-binding factors differ in their binding specificities and affinities.

1992 • 157 citations

Ultrastructural visualization of cytoskeletal mRNAs and their associated proteins using double-label in situ hybridization.

1989 • 157 citations

3'-UTR-dependent deadenylation by the yeast poly(A) nuclease.

1992 • 140 citations

Inducible transcription of five globin genes in K562 human leukemia cells.

1983 • 138 citations

U-rich sequence-binding proteins (URBPs) interacting with a 20-nucleotide U-rich sequence in the 3' untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation.

1992 • 135 citations

Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins.

1986 • 123 citations

Regulation of proto-oncogene mRNA stability

1992 • 111 citations

A Uridylate Tract Mediates Efficient Heterogeneous Nuclear Ribonucleoprotein C Protein-RNA Cross-Linking and Functionally Substitutes for the Downstream Element of the Polyadenylation Signal

1990 • 107 citations

cDNA cloning of human hnRNP protein Al reveals the existence of multiple mRNA isoforms

1988 • 107 citations

Properties of the exonuclease activity that degrades H4 histone mRNA.

1987 • 102 citations

In vitro deadenylation of mammalian mRNA by a HeLa cell 3′ exonuclease.

1991 • 102 citations

Messenger RNA turnover in cell-free extracts

1990 • 101 citations

A developmentally regulated, nervous system-specific gene in Xenopus encodes a putative RNA-binding protein.

1990 • 101 citations

c-myc RNA degradation in growing and differentiating cells: possible alternate pathways.

1989 • 98 citations

Viral small nuclear ribonucleoproteins bind a protein implicated in messenger RNA destabilization.

1992 • 72 citations

RNA-protein interactions

1991 • 71 citations

Multiple factors are required for poly(A) addition to a mRNA 3' end.

1988 • 65 citations

Isolation of RRM-type RNA-binding protein genes and the analysis of their relatedness by using a numerical approach.

1993 • 64 citations

Different complexes are formed on the 3′ end of histone mRNA with Nuclear and polyribosomal proteins

1991 • 64 citations

The histone mRNA 3′ end is required for localization of histone mRNA to polyribosomes

1992 • 57 citations

Studies on protein kinases involved in regulation of nucleocytoplasmic mRNA transport

1988 • 56 citations

Binding of sequence-specific proteins to the adenosine- plus uridine-rich sequences of the murine granulocyte/macrophage colony-stimulating factor mRNA.

1992 • 55 citations

Nuclear substructure antigens

1986 • 53 citations

Role of AUUU sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells

1991 • 48 citations

A cDNA clone of the hnRNP C proteins and its homology with the single-stranded DNA binding protein UP2

1986 • 48 citations

What determines the instability of c‐myc proto‐oncogene mRNA?

1992 • 48 citations

The end of the message: 3'– end processing leading to polyadenylated messenger RNA

1992 • 44 citations

Cloning and sequence analysis of a human type A/B hnRNP protein

1991 • 43 citations

Association of AUUUA-binding Protein with A + U-rich mRNA during nucleo-cytoplasmic transport

1992 • 33 citations

Analysis of polyadenylation site usage of thec-myconcogene

1989 • 27 citations

Monoclonal antibodies against nuclear matrix detect nuclear antigens in mammalian, insect and plant cells: An immunofluorescence study

1986 • 22 citations

Analysis of 3′‐untranslated regions of seven c‐myc genes reveals conserved elements prevalent in post‐transcriptionally regulated genes

1989 • 19 citations

Cloning of the nucleic acid-binding domain of the rat HnRNP C-type protein

1990 • 15 citations

mRNA Decay in Cell-Free Systems

1993 • 12 citations