Phosphorylation of Gi alpha 2 attenuates inhibitory adenylyl cyclase in neuroblastoma/glioma hybrid (NG-108-15) cells.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model

1985 • 732 citations

Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction

1992 • 290 citations

Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.

1979 • 288 citations

Agonist-induced Destabilization of β-Adrenergic Receptor mRNA

1989 • 267 citations

G _z -Mediated Hormonal Inhibition of Cyclic AMP accumulation

1992 • 258 citations

δ-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2

1990 • 252 citations

Stimulation of specific types of Gs-stimulated adenylyl cyclases by phorbol ester treatment.

1993 • 235 citations

Modulation of adenylate cyclase of human platelets by phorbol ester

1985 • 225 citations

Regulation of beta-adrenergic receptors by "permissive" hormones: glucocorticoids increase steady-state levels of receptor mRNA.

1988 • 196 citations

Thrombin and Phorbol Esters Cause the Selective Phosphorylation of a G Protein Other Than Gi in Human Platelets

1989 • 181 citations

Cross-regulation between G-protein-mediated pathways. Stimulation of adenylyl cyclase increases expression of the inhibitory G-protein, Gi alpha 2.

1990 • 140 citations

Site-directed Anti-peptide Antibodies Define the Topography of the β-Adrenergic Receptor

1989 • 127 citations

Induction of Gα _iI2 -Specific Antisense RNA in Vivo Inhibits Neonatal Growth

1993 • 123 citations

Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937

1989 • 119 citations

Hormonal regulation of Gi2 α-subunit phosphorylation in intact hepatocytes

1990 • 117 citations

Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.

1992 • 110 citations

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.

1991 • 110 citations

Inhibition of cloned adenylyl cyclases by mutant-activated Gi-alpha and specific suppression of type 2 adenylyl cyclase inhibition by phorbol ester treatment

1993 • 108 citations

Biosynthesis and interconversion of Drosophila nuclear lamin isoforms during normal growth and in response to heat shock.

1987 • 103 citations

Cross-talk between tyrosine kinase and G-protein-linked receptors. Phosphorylation of beta 2-adrenergic receptors in response to insulin.

1992 • 102 citations

Regulation of the Differentiation of Teratocarcinoma Cells into Primitive Endoderm by Gβ _i2

1992 • 99 citations

Pheromone-induced phosphorylation of a G protein β subunit in S. cerevisiae is associated with an adaptive response to mating pheromone

1991 • 96 citations

Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes

1990 • 95 citations

Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein G_i

1989 • 93 citations

Agonist Regulation of β-Adrenergic Receptor mRNA

1989 • 89 citations

Steady-state levels of G-proteins and beta-adrenergic receptors in rat fat cells. Permissive effects of thyroid hormones.

1988 • 83 citations

Phosphorylation of Gz in human platelets. Selectivity and site of modification.

1991 • 82 citations

Fluorescently labelled Na+ channels are localized and immobilized to synapses of innervated muscle fibres

1986 • 80 citations

Cross-regulation between G-protein-coupled receptors. Activation of beta 2-adrenergic receptors increases alpha 1-adrenergic receptor mRNA levels

1991 • 80 citations

Evidence that glucocorticoid response elements in the 5′-noncoding region of the hamster β2-adrenergic receptor gene are obligate for glucocoticoid regulation of receptor mRNA levels

1988 • 79 citations

Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation.

1993 • 77 citations

Cross-regulation between G-protein-mediated pathways. Activation of the inhibitory pathway of adenylylcylclase increases the expression of beta 2-adrenergic receptors

1991 • 77 citations

A rapid method for the measurement of [γ-32P]ATP specific radioactivity in tissue extracts and its application to the study of 32Pi uptake in perfused rat heart

1976 • 75 citations

Multiple Gi protein subtypes regulate a single effector mechanism.

1991 • 67 citations

Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors.

1993 • 60 citations

GTPase-deficient G alpha i2 oncogene gip2 inhibits adenylylcyclase and attenuates receptor-stimulated phospholipase A2 activity

1991 • 59 citations

In Vivo Receptor-Mediated Phosphorylation of a G Protein in Dictyostelium

1990 • 55 citations

Phosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gsα) by protein kinase C

1992 • 46 citations

Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2

1991 • 41 citations

Desensitization and resensitization of beta-adrenergic receptors in a smooth muscle cell line.

1985 • 37 citations

Changes in the phosphorylation state of the inhibitory guanine‐nucleotide‐binding protein G_i‐2 in hepatocytes from lean (Fa/Fa) and obese (fa/fa) Zucker rats

1990 • 35 citations

Physiological regulation at the level of mRNA: analysis of steady-state levels of specific mRNAs by DNA-excess solution hybridization

1989 • 33 citations

Cross-regulation between G-protein-mediated pathways. Acute activation of the inhibitory pathway of adenylylcyclase reduces beta 2-adrenergic receptor phosphorylation and increases beta-adrenergic responsiveness.

1992 • 28 citations

Phosphorylation of the recombinant spliced variants of the α-sub-unit of the stimulatory guanine-nucleotide binding regulatory protein (Gs) by the catalytic sub-unit of protein kinase a

1992 • 27 citations

Hormonal stimulation of cyclic AMP accumulation and glycogen phosphorylase activity in calcium-depleted hepatocytes from euthyroid and hypothyroid rats

1980 • 14 citations

Trends in Cardiovascular Medicine

1992 • 8 citations