A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

Variety in the level of gene control in eukaryotic cells

1982 • 772 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

Role of the Conserved AAUAAA Sequence: Four AAUAAA Point Mutants Prevent Messenger RNA 3′ End Formation

1984 • 561 citations

Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing

1978 • 478 citations

α-Thalassaemia caused by a polyadenylation signal mutation

1983 • 407 citations

Heterogeneous Nuclear Ribonucleoproteins: Role in RNA Splicing

1986 • 399 citations

Are U4 small nuclear ribonucleoproteins involved in polyadenylation?

1984 • 379 citations

Physical change in cytoplasmic messenger ribonucleoproteins in cells treated with inhibitors of mRNA transcription.

1984 • 334 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA

1986 • 283 citations

Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

1983 • 278 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

Sequence at the 3′ end of globin mRNA shows homology with immunoglobulin light chain mRNA

1974 • 256 citations

The Role of the Poly(A) Sequence in Mammalian Messenger RN

1981 • 254 citations

Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m ⁷ GpppNm) on RNAs and in initiating viral RNA transcription

1981 • 252 citations

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

1984 • 251 citations

Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins.

1987 • 229 citations

Site-specific polyadenylation in a cell-free reaction

1984 • 223 citations

Analysis of processing and polyadenylation signals of the hepatitis B virus surface antigen gene by using simian virus 40-hepatitis B virus chimeric plasmids.

1983 • 164 citations

Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences

1985 • 152 citations

The AAUAAA sequence is required both for cleavage and for polyadenylation of simian virus 40 pre-mRNA in vitro.

1986 • 147 citations

Mode of regulation of immunoglobulin μ- and δ-chain expression varies during B-lymphocyte maturation

1984 • 146 citations

A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytes.

1985 • 139 citations

A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitro

1986 • 139 citations

Tissue-specific expression of two mRNA species transcribed from a single vimentin gene

1983 • 123 citations

Cross‐linking of mRNA to Proteins by Irradiation of Intact Cells with Ultraviolet Light

1980 • 122 citations

Sequences on the 3' side of hexanucleotide AAUAAA affect efficiency of cleavage at the polyadenylation site.

1984 • 113 citations

Photochemical Cross-Linking of Cap Binding Proteins to Eucaryotic mRNAs: Effect of mRNA 5′ Secondary Structure

1985 • 102 citations

Formation of mRNA 3′ termini: stability and dissociation of a complex involving the AAUAAA sequence.

1987 • 83 citations

Polyadenylate Polymerases

1976 • 82 citations

The Regulatory Function of Poly(A) and Adjacent 3' Sequences in Translated RNA

1982 • 80 citations

Proteins crosslinked to messenger RNA by irradiating polyribosomes with ultraviolet light

1980 • 71 citations

Isolation and partial characterization of the poly(A) polymerases from HeLa cells infected with vaccinia virus.

1977 • 66 citations

Mutations downstream of the polyadenylation site of a Xenopus β-globin mRNA affect the position but not the efficiency of 3′ processing

1986 • 63 citations

Requirements for accurate and efficient mRNA 3' end cleavage and polyadenylation of a simian virus 40 early pre-RNA in vitro.

1987 • 56 citations

Photochemical cross-linking of cap binding proteins to eucaryotic mRNAs: effect of mRNA 5' secondary structure.

1985 • 55 citations

Adenovirus gene expression: Control at multiple steps of mRNA biogenesis

1982 • 43 citations

In vitro assembly of a pre-messenger ribonucleoprotein.

1983 • 28 citations

Selection of Sequence elements that substitute for the standard AATAAA motif which signals 3′ processing and polyadenylation of late simian virus 40 mRNAs

1985 • 25 citations