The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

1997 • 2,201 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Regulators of cell death

1995 • 647 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation

1996 • 494 citations

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

1996 • 440 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1996 • 344 citations

p53 in signaling checkpoint arrest or apoptosis

1996 • 336 citations

Apoptosis and the cell cycle

1995 • 334 citations

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1995 • 334 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death.

1996 • 284 citations

Mitogen-Activated and Cyclin-Dependent Protein Kinases Selectively and Differentially Modulate Transcriptional Enhancement by the Glucocorticoid Receptor

1997 • 271 citations

Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons

1997 • 270 citations

Receptor-stimulated death pathway is opened by antigen in mature T cells.

1991 • 255 citations

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis.

1996 • 244 citations

Suppression of Apoptosis by Dominant Negative Mutants of Cyclin-dependent Protein Kinases

1996 • 239 citations

Activation-induced apoptosis in lymphocytes

1994 • 238 citations

The role of the Caspase family of cysteine proteases in apoptosis

1997 • 210 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death

1997 • 170 citations

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

1996 • 170 citations

Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival.

1996 • 167 citations

Protein Phosphatase Types 1 and/or 2A Regulate Nucleocytoplasmic Shuttling of Glucocorticoid Receptors

1991 • 153 citations

Chemical inhibitors of cyclin-dependent kinases

1997 • 138 citations

Death-defying acts: a meeting review on apoptosis.

1993 • 132 citations

Hormone-dependent phosphorylation of the glucocorticoid receptor occurs mainly in the amino-terminal transactivation domain.

1990 • 112 citations

Tolerance induction by clonal deletion of CD4⁺8⁺ thymocytes in vitro does not require dedicated antigen‐presenting cells

1993 • 97 citations

Purification and Characterization of an Interleukin-1β-converting Enzyme Family Protease That Activates Cysteine Protease P32 (CPP32)

1996 • 87 citations

Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding

1997 • 79 citations

Molecular and Cellular Mechanisms of T Lymphocyte Apoptosis

1998 • 72 citations

Signaling for death of lymphoid cells

1993 • 71 citations

CD4/CD8 lineage commitment: back to instruction?

1996 • 57 citations

Fas stimulation induces RB dephosphorylation and proteolysis that is blocked by inhibitors of the ICE protease family

1997 • 47 citations

Multiple Pathways of Fas-Induced Apoptosis in Primary Culture of Hepatocytes

1996 • 45 citations

TCR-mediated death of mature T lymphocytes occurs in the absence of p53.

1996 • 38 citations

Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis

1997 • 33 citations

The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker.

1997 • 20 citations