Cancer dormancy and cell signaling: Induction of p21^waf1initiated by membrane IgM engagement increases survival of B lymphoma cells

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.

1998 • 2,777 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Humanization of an anti-p185HER2 antibody for human cancer therapy.

1992 • 1,867 citations

IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma

1997 • 1,652 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

Rituximab (Anti-CD20 Monoclonal Antibody) for the Treatment of Patients With Relapsing or Refractory Aggressive Lymphoma: A Multicenter Phase II Study

1998 • 914 citations

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1996 • 746 citations

p185^HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

1989 • 672 citations

IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma.

1997 • 638 citations

Apoptosis of Malignant Human B Cells by Ligation of CD20 With Monoclonal Antibodies

1998 • 576 citations

Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation

1996 • 494 citations

Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade

1998 • 441 citations

Apoptosis and the cell cycle

1995 • 431 citations

Chimeric Anti-CD20 (IDEC-C2B8) Monoclonal Antibody Sensitizes a B Cell Lymphoma Cell Line to Cell Killing by Cytotoxic Drugs

1997 • 411 citations

Cell-cycle arrest versus cell death in cancer therapy

1997 • 394 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

Resistance to Fas-mediated apoptosis: activation of Caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

1998 • 355 citations

Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition.

1993 • 349 citations

p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

1997 • 305 citations

Anti‐immunoglobulin antibodies induce apoptosis in immature B cell lymphomas

1990 • 253 citations

Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

1999 • 238 citations

The Cyclin-Dependent Kinase Inhibitor p21^WAF1 Is Required for Survival of Differentiating Neuroblastoma Cells

1996 • 226 citations

Cleavage of CDK Inhibitor p21Cip1/Waf1 by Caspases Is an Early Event during DNA Damage-induced Apoptosis

1998 • 215 citations

Protective Role of p21^Waf1/Cip1 against Prostaglandin A₂-Mediated Apoptosis of Human Colorectal Carcinoma Cells

1996 • 160 citations

Repair Defect in p21 WAF1/CIP1 -/- human cancer cells.

1996 • 158 citations

Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21

1999 • 157 citations

Feasibility and pharmacokinetic study of a chimeric anti-CD20 monoclonal antibody (IDEC-C2B8, rituximab) in relapsed B-cell lymphoma

1998 • 152 citations

Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes

1986 • 146 citations

p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage

1998 • 145 citations

Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism.

1997 • 118 citations

Induction of Cip/Kip and Ink4 cyclin dependent kinase inhibitors by interferon-α in hematopoietic cell lines

1997 • 116 citations

Interferon-induces expression of cyclin-dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK)

1998 • 114 citations

Growth Inhibition of CD20‐positive B Lymphoma Cell Lines by IDEC‐C2B8 Anti‐CD20 Monoclonal Antibody

1998 • 78 citations

Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.

1994 • 77 citations

Therapy of lymphoma directed at idiotypes.

1990 • 73 citations

Cancer dormancy: isolation and characterization of dormant lymphoma cells.

1993 • 69 citations

Cancer dormancy: studies of the murine BCL1 lymphoma.

1991 • 67 citations

Caspase 3 specifically cleaves p21^WAF1/CIP1 in the earlier stage of apoptosis in SK‐HEP‐1 human hepatoma cells

1998 • 67 citations

Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line

1998 • 65 citations

Role of p21 in prostaglandin A2-mediated cellular arrest and death.

1996 • 61 citations

Tumor dormancy and cell signaling. II. Antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice.

1995 • 55 citations

Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis

1997 • 51 citations

Antigen receptor-induced cell cycle arrest in WEHI-231 B lymphoma cells depends on the duration of signaling before the G1 phase restriction point.

1990 • 48 citations

Clinical Trials of Idiotype-Specific Vaccine in B-Cell Lymphomas

1993 • 45 citations

Tumour dormancy and cell signalling--III: Role of hypercrosslinking of IgM and CD40 on the induction of cell cycle arrest and apoptosis in B lymphoma cells.

1995 • 37 citations

Cancer dormancy: role of cyclin-dependent kinase inhibitors in induction of cell cycle arrest mediated via membrane IgM.

1998 • 36 citations

Lymphoma models for B-cell activation and tolerance: anti-immunoglobulin M treatment induces growth arrest by preventing the formation of an active kinase complex which phosphorylates retinoblastoma gene product in G1.

1995 • 31 citations

Anti-IgM-mediated growth inhibition of a human B lymphoma cell line is independent of phosphatidylinositol turnover and protein kinase C activation and involves tyrosine phosphorylation.

1991 • 30 citations

Antigen Receptor-Induced Cell Cycle Arrest in WEHI-231 B Lymphoma Cells Depends on the Duration of Signaling before the G₁ Phase Restriction Point

1990 • 10 citations