p21WAF1/CIP1 Inhibits Initiator Caspase Cleavage by TRAIL Death Receptor DR4

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

1998 • 1,927 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL

1997 • 1,119 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

1998 • 781 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

A novel receptor for Apo2L/TRAIL contains a truncated death domain

1997 • 650 citations

Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation

1999 • 587 citations

Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

1997 • 566 citations

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

1998 • 534 citations

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

1998 • 531 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation

1996 • 494 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

1999 • 408 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

Resistance to Fas-mediated apoptosis: activation of Caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

1998 • 355 citations

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

1998 • 327 citations

Solution Structure of the RAIDD CARD and Model for CARD/CARD Interaction in Caspase-2 and Caspase-9 Recruitment

1998 • 302 citations

AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

1997 • 285 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosisin vivo

1998 • 244 citations

The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis

1999 • 238 citations

Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA

1996 • 198 citations

Activation of Caspase-2 in Apoptosis

1997 • 181 citations

p21/p53, Cellular Growth Control and Genomic Integrity

1998 • 177 citations

Activation of the Apoptotic Endonuclease DFF40 (Caspase-activated DNase or Nuclease)

1999 • 168 citations

Cleavage of DFF-45/ICAD by Multiple Caspases Is Essential for Its Function during Apoptosis

1998 • 163 citations

Protective Role of p21^Waf1/Cip1 against Prostaglandin A₂-Mediated Apoptosis of Human Colorectal Carcinoma Cells

1996 • 160 citations

Repair Defect in p21 WAF1/CIP1 -/- human cancer cells.

1996 • 158 citations

Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21

1999 • 157 citations

Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard

1997 • 153 citations

p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage

1998 • 145 citations

Functional Activation of Nedd2/ICH-1 (Caspase-2) Is an Early Process in Apoptosis

1997 • 142 citations

Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2.

1996 • 127 citations

Transition from Caspase-dependent to Caspase-independent Mechanisms at the Onset of Apoptotic Execution

1998 • 120 citations

Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli

1999 • 120 citations

Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells.

1999 • 115 citations

Functional Differences of Two Forms of the Inhibitor of Caspase-activated DNase, ICAD-L, and ICAD-S

1999 • 94 citations

c-E10 Is a Caspase-recruiting Domain-containing Protein That Interacts with Components of Death Receptors Signaling Pathway and Activates Nuclear Factor-κB

1999 • 81 citations

Functional Interaction of DFF35 and DFF45 with Caspase-activated DNA Fragmentation Nuclease DFF40

1999 • 80 citations

Identification of Regulatory and Catalytic Domains in the Apoptosis Nuclease DFF40/CAD

1999 • 65 citations

ICAD/DFF Regulator of Apoptotic Nuclease Is Nuclear

1998 • 54 citations

Inhibition of Apoptosis-Associated DNA Fragmentation Activity in Nonapoptotic Cells: The Role of DNA Fragmentation Factor-45 (DFF45/ICAD)

1998 • 51 citations

Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction.

1996 • 42 citations

Identification of the Nuclear Factor HMG2 as an Activator for DFF Nuclease Activity

1998 • 38 citations

Cytosolic Nuclease Activated by Caspase-3 and Inhibited by DFF-45

1998 • 38 citations

Bypass of abnormal MDM2 inhibition of p53-dependent growth suppression.

1998 • 33 citations

Cyclin Dependent Kinase (CDK) Inhibitors

1998 • 33 citations

The administration schedule of cyclin-dependent kinase inhibitor gene therapy and etoposide chemotherapy is a major determinant of cytotoxicity.

1999 • 13 citations

Science--Far More Than Required High School Coursework

1998 • 1 citations