p21 ^WAF1/Cip1 functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential

Biostatistical Analysis

1996 • 36,713 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis

1990 • 2,262 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

1980 • 1,810 citations

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

1993 • 1,102 citations

Physiology, Biochemistry, and Molecular Biology of the Skin

1992 • 791 citations

Stem cell patterning and fate in human epidermis

1995 • 788 citations

Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation

1999 • 587 citations

Location of stem cells of human hair follicles by clonal analysis

1994 • 521 citations

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1993 • 465 citations

Physiology, biochemistry, and molecular biology of the skin

1991 • 434 citations

Differentiation-Linked Leukemogenesis in Lymphocytes

1986 • 359 citations

Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.

1995 • 338 citations

The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

1996 • 323 citations

Dacapo, a Cyclin-Dependent Kinase Inhibitor, Stops Cell Proliferation during Drosophila Development

1996 • 319 citations

A Cyclin-Dependent Kinase Inhibitor, Dacapo, Is Necessary for Timely Exit from the Cell Cycle during Drosophila Embryogenesis

1996 • 314 citations

Neoplastic Development

1970 • 295 citations

Inhibitory Function of p21 ^Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control

1998 • 285 citations

Kalinin is more efficient than laminin in promoting adhesion of primary keratinocytes and some other epithelial cells and has a different requirement for integrin receptors.

1994 • 252 citations

Selection and Extended Growth of Murine Epidermal Stem Cells in Culture

1998 • 212 citations

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

1998 • 154 citations

Ultraviolet Light Induces Expression of p53 and p21 in Human Skin: Effect of Sunscreen and Constitutive p21 Expression in Skin Appendages

1995 • 154 citations

Induction of papillomas with a high probability of conversion to malignancy

1985 • 132 citations

p21 (WAF1/CIP1) Expression Is Induced in Newly Nondividing Cells in Diverse Epithelia and during Differentiation of the Caco-2 Intestinal Cell Line

1996 • 119 citations

In vivo regulation of murine hair growth: Insights from grafting defined cell populations onto nude mice

1993 • 119 citations

Upper Human Hair Follicle Contains a Subpopulation of Keratinocytes with Superior In Vitro Proliferative Potential

1993 • 117 citations

Primary Mouse Keratinocyte Cultures Contain Hair Follicle Progenitor Cells with Multiple Differentiation Potential

1997 • 97 citations

[56] Lineage analysis using retrovirus vectors

1993 • 96 citations

Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis

1998 • 87 citations

Stem cells in differentiation and neoplasia

1982 • 86 citations

Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling.

1997 • 84 citations

Proliferative Potential of Different Keratinocytes of Plucked Human Hair Follicles

1995 • 69 citations

Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis.

1999 • 66 citations

Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha.

1996 • 58 citations

Analysis of centrosome abnormalities and angiogenesis in epidermal-targetedp53172H mutant andp53-knockout mice after chemical carcinogenesis: Evidence for a gain of function

1998 • 56 citations

[25] Lineage analysis using retrovirus vectors

1995 • 41 citations

Deregulated expression of cell-cycle proteins during premalignant progression in SENCAR mouse skin

1998 • 38 citations

Fibroblast-dependent induction of a murine skin lesion with similarity to human common blue nevus.

1996 • 36 citations

Evidence that initiated keratinocytes clonally expand into multiple existing hair follicles during papilloma histogenesis in SENCAR mouse skin

1997 • 26 citations

Papillomas at high risk for malignant progression arising both early and late during two-stage carcinogenesis in SENCAR mice

1998 • 18 citations

Hair Follicle Stem Cells: Characteristics and Possible Significance

1994 • 13 citations