The Cyclin-Dependent Kinase Inhibitor p21^WAF1 Is Required for Survival of Differentiating Neuroblastoma Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

p53 function and dysfunction

1992 • 1,918 citations

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1985 • 1,836 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

The MyoD family and myogenesis: Redundancy, networks, and thresholds

1993 • 1,062 citations

p53-Independent Expression of p21 ^Cip1 in Muscle and Other Terminally Differentiating Cells

1995 • 1,058 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

Gene inhibition using antisense oligodeoxynucleotides

1994 • 746 citations

Association between High Levels of Expression of the TRK Gene and Favorable Outcome in Human Neuroblastoma

1993 • 698 citations

p21-containing cyclin kinases exist in both active and inactive states.

1994 • 646 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Do all programmed cell deaths occur via apoptosis?

1993 • 545 citations

Activation of Epstein–Barr virus latent genes protects human B cells from death by apoptosis

1991 • 525 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

Induction of p21 (WAF-1/CIP1) during differentiation.

1994 • 493 citations

The Cell Cycle

1989 • 468 citations

High-frequency developmental abnormalities in p53-deficient mice

1995 • 464 citations

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system

1993 • 453 citations

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

1995 • 421 citations

Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase

1995 • 404 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

1993 • 253 citations

Coexpression of messenger RNA for TRK protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis.

1993 • 208 citations

Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways.

1994 • 196 citations

Absence of p53 gene mutations in primary neuroblastomas.

1993 • 195 citations

Lack of High-Affinity Nerve Growth Factor Receptors in Aggressive Neuroblastomas

1993 • 189 citations

NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

1995 • 177 citations

Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation.

1989 • 176 citations

Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines

1982 • 168 citations

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

1995 • 158 citations

Enhanced chemiluminescent method for the detection of DNA dot-hybridization assays

1985 • 154 citations

Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

1994 • 150 citations

RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis

1993 • 141 citations

Mutations of the p53 gene are involved in Ewing's sarcomas but not in neuroblastomas.

1993 • 138 citations

Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts

1994 • 125 citations

Cisplatin Induces Apoptosis in a Human Ovarian Carcinoma Cell Line without Concomitant Internucleosomal Degradation of DNA

1994 • 123 citations

Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.

1995 • 120 citations

Regression of Neuroblastoma IV-S: A Genetic Hypothesis

1980 • 118 citations

Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines.

1992 • 117 citations

Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3.

1995 • 115 citations

Structure and developmental expression of the chicken CDC2 kinase.

1989 • 103 citations

Downregulation of CDC2 upon terminal differentiation of neurons.

1991 • 86 citations

Neuronal differentiation triggered by blocking cell proliferation.

1992 • 68 citations

Cyclin E is expressed in neurons and forms complexes with cdk5

1995 • 65 citations

Analysis of nerve growth factor receptor expression in human neuroblastoma and neuroepithelioma cell lines.

1989 • 62 citations

TrkA neurogenic receptor regulates differentiation of neuroblastoma cells.

1995 • 60 citations

Nerve growth factor-induced differentiation of human neuroblastoma and neuroepithelioma cell lines.

1990 • 56 citations

Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells.

1994 • 50 citations

Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors.

1993 • 43 citations

Phenotypic differentiation of aphidicolin-selected human neuroblastoma cultures after long-term exposure to nerve growth factor

1987 • 43 citations

Differential expression of D type cyclins during neuronal maturation

1994 • 39 citations

Functions of the p53 Protein in Growth Regulation and Tumor Suppression

1994 • 32 citations