Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Principles of CDK regulation

1995 • 3,267 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Caspases: killer proteases

1997 • 2,440 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

Inhibition of cyclin-dependent kinases by p21.

1995 • 999 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

1994 • 657 citations

Caspases and caspase inhibitors

1997 • 573 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

1995 • 561 citations

Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

1995 • 552 citations

Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation

1996 • 494 citations

Genetic determinants of p53-induced apoptosis and growth arrest.

1996 • 472 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade

1998 • 441 citations

Apoptosis and the cell cycle

1995 • 431 citations

Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.

1994 • 415 citations

Cell cycle and apoptosis: Common pathways to life and death

1995 • 404 citations

Identification of a Cyclin-cdk2 Recognition Motif Present in Substrates and p21-Like Cyclin-Dependent Kinase Inhibitors

1996 • 368 citations

Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.

1994 • 352 citations

p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

1997 • 305 citations

Actin cleavage by CPP-32/apopain during the development of apoptosis

1997 • 251 citations

Suppression of Apoptosis by Dominant Negative Mutants of Cyclin-dependent Protein Kinases

1996 • 239 citations

The Cyclin-Dependent Kinase Inhibitor p21^WAF1 Is Required for Survival of Differentiating Neuroblastoma Cells

1996 • 226 citations

Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.

1995 • 186 citations

Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases

1998 • 161 citations

Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage.

1995 • 156 citations

Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

1997 • 153 citations

Aspartate-Based Inhibitor of Interleukin-1β-Converting Enzyme Prevents Antitumor Agent-Induced Apoptosis in Human Myeloid Leukemia U937 Cells

1995 • 151 citations

Activation-Induced T-Cell Death Is Cell Cycle Dependent and Regulated by Cyclin B

1995 • 126 citations

The C-terminal Region of p21 Is Involved in Proliferating Cell Nuclear Antigen Binding but Does Not Appear to Be Required for Growth Inhibition

1995 • 91 citations

Comments on Burnette, Deutsch, and Summerhill

1996 • 3 citations