The Chemokine Receptor CXCR4 Regulates Cell-Cycle Proteins in Neurons

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

Pathways to neuronal injury and apoptosis in HIV-associated dementia

2001 • 1,190 citations

The Rb/E2F pathway: expanding roles and emerging paradigms

2000 • 1,125 citations

CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

2001 • 1,024 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity

1998 • 697 citations

Apaf-1 is a transcriptional target for E2F and p53

2001 • 590 citations

Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis

1999 • 513 citations

Rb function in cell-cycle regulation and apoptosis

2000 • 511 citations

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

2002 • 449 citations

Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4

1998 • 419 citations

Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor

2002 • 413 citations

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1995 • 403 citations

Ephrin-B Reverse Signaling Is Mediated by a Novel PDZ-RGS Protein and Selectively Inhibits G Protein–Coupled Chemoattraction

2001 • 382 citations

Expression of CX₃CR1 chemokine receptors on neurons and their role in neuronal survival

2000 • 375 citations

A Dual Role for the SDF-1/CXCR4 Chemokine Receptor System in Adult Brain: Isoform-Selective Regulation of SDF-1 Expression Modulates CXCR4-Dependent Neuronal Plasticity and Cerebral Leukocyte Recruitment after Focal Ischemia

2002 • 372 citations

Chemokines in the CNS: plurifunctional mediators in diverse states

1999 • 345 citations

Signaling Networks That Link Cell Proliferation and Cell Fate

2002 • 339 citations

Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia

1999 • 302 citations

Chemokine and chemokine receptor expression in the central nervous system

1999 • 293 citations

SDF-1α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells

2001 • 292 citations

Cyclin-dependent kinases as a therapeutic target for stroke

2000 • 276 citations

Stromal cell–derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in CD34+ cells: evidence for an autocrine/paracrine mechanism

2002 • 276 citations

RB kinases and RB-binding proteins: new points of view

1997 • 264 citations

Packaging system for rapid production of murine leukemia virus vectors with variable tropism

1992 • 260 citations

E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways

1999 • 244 citations

Akt Activation Protects Hippocampal Neurons from Apoptosis by Inhibiting Transcriptional Activity of p53

2001 • 243 citations

Role of Cell Cycle Regulatory Proteins in Cerebellar Granule Neuron Apoptosis

1999 • 238 citations

Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons

2002 • 238 citations

Caspase Cascades in Human Immunodeficiency Virus-Associated Neurodegeneration

2002 • 224 citations

Glial and Neuronal Cells Express Functional Chemokine Receptor CXCR4 and Its Natural Ligand Stromal Cell‐Derived Factor 1

1999 • 220 citations

gp120-Induced Neurotoxicity in Hippocampal Pyramidal Neuron Cultures: Protective Action of TGF-β1

1996 • 204 citations

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3

2000 • 203 citations

Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis.

1999 • 155 citations

Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage

2000 • 151 citations

Induction and Modulation of Cerebellar Granule Neuron Death by E2F-1

2000 • 143 citations

Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice

2002 • 139 citations

AIDS and the brain: is there a chemokine connection?

1999 • 135 citations

The Retinoblastoma Gene: A Prototypic and Multifunctional Tumor Suppressor

2001 • 133 citations

Developmental pattern of expression of the alpha chemokine stromal cell‐derived factor 1 in the rat central nervous system

2001 • 132 citations

SDF‐1α‐mediated modulation of synaptic transmission in rat cerebellum

2000 • 123 citations

Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: A study with rat cerebellar granule cell cultures

1993 • 113 citations

Cell Cycle and Biochemical Effects of PD 0183812

2001 • 110 citations

Acute versus chronic NMDA receptor blockade and synaptic AMPA receptor delivery

2002 • 97 citations

Cell Cycle Proteins Exhibit Altered Expression Patterns in Lentiviral-Associated Encephalitis

2002 • 73 citations

pRb and E2f-1 in mouse development and tumorigenesis

1999 • 69 citations

Induction of Cell-Cycle Regulators in Simian Immunodeficiency Virus Encephalitis

2000 • 65 citations

Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway

1999 • 63 citations

Expression Pattern of CXCR3, CXCR4, and CCR3 Chemokine Receptors in the Developing Human Brain

2001 • 48 citations

Regulation of the Retinoblastoma-Dependent Mdm2 and E2F-1 Signaling Pathways during Neuronal Apoptosis

2001 • 35 citations

Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product.

1996 • 30 citations

Chemokines and viral diseases of the central nervous system

2001 • 25 citations

Chemokines and chemokine receptors in model neurological pathologies: Molecular and immunocytochemical approaches

1997 • 23 citations

Chemokine Regulation of Hematopoiesis and the Involvement of Pertussis Toxin‐Sensitive G_αi Proteins

2001 • 21 citations

Nuclear localization conferred by the pocket domain of the retinoblastoma gene product

1999 • 18 citations