Cell Cycle Proteins Exhibit Altered Expression Patterns in Lentiviral-Associated Encephalitis

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex

1988 • 1,244 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Prognostic classification of breast ductal carcinoma-in-situ

1995 • 678 citations

Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia

1995 • 663 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

Apaf-1 is a transcriptional target for E2F and p53

2001 • 590 citations

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1997 • 417 citations

Neuropathology of Human Immunodeficiency Virus Infection

1991 • 411 citations

Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity

1991 • 397 citations

Mitotic mechanisms in Alzheimer's disease?

1996 • 384 citations

Mutation of E2f-1 Suppresses Apoptosis and Inappropriate S Phase Entry and Extends Survival of Rb-Deficient Mouse Embryos

1998 • 375 citations

Spectrum of human immunodeficiency virus–associated neocortical damage

1992 • 369 citations

Cerebral white matter changes in acquired immunodeficiency syndrome dementia: Alterations of the blood‐brain barrier

1993 • 333 citations

Changes in pathological findings at autopsy in AIDS cases for the last 15 years

2000 • 327 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

HIV‐Associated Disease of the Nervous System: Review of Nomenclature and Proposal for Neuropathology‐Based Terminology

1991 • 323 citations

Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin

1994 • 317 citations

Cell cycle markers in the hippocampus in Alzheimer's disease

1997 • 315 citations

Temporal trends in the incidence of HTV‐1‐related neurologic diseases

1994 • 305 citations

G1/S Cell Cycle Blockers and Inhibitors of Cyclin-Dependent Kinases Suppress Camptothecin-Induced Neuronal Apoptosis

1997 • 275 citations

Distribution of Brain HIV Load in AIDS

1998 • 252 citations

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimerʼs disease

1996 • 244 citations

E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways

1999 • 244 citations

Involvement of Cell Cycle Elements, Cyclin-dependent Kinases, pRb, and E2F·DP, in B-amyloid-induced Neuronal Death

1999 • 242 citations

Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome

1994 • 230 citations

Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions

1997 • 227 citations

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3

2000 • 203 citations

Key Roles for E2F1 in Signaling p53-Dependent Apoptosis and in Cell Division within Developing Tumors

1998 • 192 citations

Neuronal Death Induced by Brain-Derived Human Immunodeficiency Virus Type 1 Envelope Genes Differs between Demented and Nondemented AIDS Patients

1998 • 177 citations

Cyclins, CDKs and cancer

1995 • 176 citations

Study of Receptor-Mediated Neurotoxins Released by HIV-1-Infected Mononuclear Phagocytes Found in Human Brain

1996 • 165 citations

Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage

2000 • 151 citations

Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques

1998 • 150 citations

Transcriptional control by E2F

1995 • 147 citations

Cell division and the nervous system: regulating the cycle from neural differentiation to death

1996 • 147 citations

Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulence

1997 • 139 citations

Brain Viral Burden in HIV Infection

1994 • 138 citations

The role of E2F in the mammalian cell cycle

1993 • 136 citations

Pathogenesis of SIV encephalitis. Selection and replication of neurovirulent SIV.

1997 • 131 citations

Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease

1999 • 128 citations

Regulation of E2F: a family of transcription factors involved in proliferation control

1999 • 120 citations

Simian immunodeficiency virus encephalitis in Rhesus Macaques is associated with rapid disease progression

1998 • 107 citations

Adenovirus–mediated retinoblastoma gene therapy suppresses spontaneous pituitary melanotroph tumors in Rb+/− mice

1996 • 91 citations

HIV mediates a productive infection of the brain

1999 • 88 citations

Cytokine expression of macrophages in HIV‐1‐associated vacuolar myelopathy

1993 • 85 citations

Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.

1996 • 82 citations

E2F-1 Blocks Terminal Differentiation and Causes Proliferation in Transgenic Megakaryocytes

1996 • 82 citations

HIV-1 envelope protein evokes intracellular calcium oscillations in rat hippocampal neurons

1992 • 79 citations

Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis

2001 • 75 citations

Quinolinic Acid in the Cerebrospinal Fluid of Children with Symptomatic Human Immunodeficiency Virus Type 1 Disease: Relationships to Clinical Status and Therapeutic Response

1993 • 74 citations

Transcriptional control by the retinoblastoma protein

1995 • 69 citations

HIV-associated brain pathology in the United Kingdom

1997 • 68 citations

Induction of Cell-Cycle Regulators in Simian Immunodeficiency Virus Encephalitis

2000 • 65 citations

A developmentally regulated DNA-binding protein from mouse brain stimulates myelin basic protein gene expression.

1993 • 64 citations

Role of macrophages in the pathogenesis of human immunodeficiency virus (HIV) infection

1995 • 62 citations

The retinoblastoma protein and its relatives

1995 • 62 citations

Serial pathogenesis study of SIV brain infection.

1991 • 62 citations

The transcription factor E2F1 promotes dopamine‐evoked neuronal apoptosis by a mechanism independent of transcriptional activation

2001 • 56 citations

Correlates of SIV encephalitis in rhesus monkeys

1992 • 54 citations

Serial pathogenesis study of SIV brain infection

1991 • 48 citations

Inflammation in AIDS and the role of the macrophage in brain pathology

1996 • 45 citations

Expression of Major Histocompatibility Complex Antigens in the Brains of Patients with Progressive Multifocal Leukoencephalopathy

1992 • 44 citations

Changing incidence of HIV-induced brain lesions in Oslo, 1983–1994

1995 • 40 citations

Efficient infection of brain microvascular endothelial cells by aninvivo-selected neuroinvasive SIV_macvariant

1998 • 37 citations

Monokine products as predictors of AIDS dementia

1996 • 37 citations

Detailed analysis of the basic domain of the E2F1 transcription factor indicates that it is unique among bHLH proteins.

1994 • 35 citations

Sources of the neurotoxin quinolinic acid in the brain of HIV‐1‐infected patients and retrovirus‐infected macaques

1998 • 33 citations

Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV-encephalitic brain is macrophage-tropic but not neurovirulent

1995 • 32 citations

Investigation of HIV-infected macrophage neurotoxin production from patients with AIDS dementia

1994 • 28 citations

Response of Cell Cycle Proteins to Neurotrophic Factor and Chemokine Stimulation in Human Neuroglia

2001 • 25 citations

Regulation of c-myc transcription in vitro: dependence on the guanine-rich promoter element ME1a1.

1990 • 22 citations

A Developmentally Regulated DNA-Binding Protein from Mouse Brain Stimulates Myelin Basic Protein Gene Expression

1993 • 22 citations

Confocal microscopy assessment of lymphoid tissues with follicular hyperplasia from patients infected with human immunodeficiency virus type 1.

1998 • 19 citations

Impact of various simian immunodeficiency virus variants on induction and nature of neuropathology in macaques

1996 • 16 citations

Regulation of c-myc transcription in vitro: dependence on the guanine-rich promoter element ME1a1.

1990 • 2 citations