Chemokines in the CNS: plurifunctional mediators in diverse states

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1996 • 2,502 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion

1997 • 1,406 citations

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

1998 • 1,118 citations

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

1997 • 1,078 citations

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

1999 • 999 citations

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

1997 • 923 citations

Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy–negative individuals

1995 • 731 citations

Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins

1993 • 722 citations

Defects in Macrophage Recruitment and Host Defense in Mice Lacking the CCR2 Chemokine Receptor

1997 • 700 citations

Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity

1998 • 697 citations

Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow

1998 • 679 citations

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2

1997 • 671 citations

Lymphotactin: a Cytokine that Represents a New Class of Chemokine

1994 • 668 citations

Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog

1994 • 666 citations

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

1997 • 656 citations

Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia

1998 • 568 citations

Astrocyte expression of mRNA encoding cytokines IP‐10 and JE/MCP‐1 in experimental autoimmune encephalomyelitis

1993 • 496 citations

An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis.

1995 • 487 citations

Impaired Host Defense, Hematopoiesis, Granulomatous Inflammation and Type 1–Type 2 Cytokine Balance in Mice Lacking CC Chemokine Receptor 1

1997 • 454 citations

Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4

1998 • 419 citations

Recent Advances in Chemokines and Chemokine Receptors

1999 • 414 citations

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

1995 • 412 citations

Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions

1998 • 400 citations

Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1.

1995 • 389 citations

Expression of chemokine receptors by subsets of neurons in the central nervous system.

1997 • 384 citations

MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization study

1998 • 371 citations

Localization of fractalkine and CX₃CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?

1998 • 334 citations

?-Chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia

1998 • 331 citations

Chemokine and chemokine receptor expression in the central nervous system

1999 • 293 citations

Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes.

1996 • 288 citations

Neuronal apoptosis in HIV infection in adults

1995 • 244 citations

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

1993 • 244 citations

Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat.

1996 • 244 citations

Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease

1997 • 238 citations

CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons.

1997 • 235 citations

Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis.

1998 • 229 citations

Intrathecal release of pro- and anti-inflammatory cytokines during stroke

1997 • 229 citations

The Chemokine Growth-Regulated Oncogene-α Promotes Spinal Cord Oligodendrocyte Precursor Proliferation

1998 • 227 citations

Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model.

1998 • 223 citations

Apoptotic neurons in brains from paediatric patients with HIV‐I encephalitis and progressive encephalopathy

1995 • 220 citations

Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease.

1998 • 220 citations

Binding and Functional Properties of Recombinant and Endogenous CXCR3 Chemokine Receptors

1998 • 212 citations

Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury

1998 • 209 citations

Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation?

1998 • 195 citations

Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis

1997 • 192 citations

Cutting Edge Commentary: Chemokine Regulation of Experimental Autoimmune Encephalomyelitis: Temporal and Spatial Expression Patterns Govern Disease Pathogenesis

1998 • 182 citations

Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes.

1997 • 182 citations

OVERRIDING THE BRAIN'S INTRINSIC RESISTANCE TO LEUKOCYTE RECRUITMENT WITH INTRAPARENCHYMAL INJECTIONS OF RECOMBINANT CHEMOKINES

1996 • 181 citations

Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells.

1995 • 176 citations

Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS.

1998 • 175 citations

Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration

1997 • 175 citations

Amyloid-β Induces Chemokine Secretion and Monocyte Migration across a Human Blood-Brain Barrier Model

1998 • 172 citations

Dynamic Regulation of α- and β-Chemokine Expression in the Central Nervous System During Mouse Hepatitis Virus-Induced Demyelinating Disease

1998 • 170 citations

Identification of Single C Motif-1/Lymphotactin Receptor XCR1

1998 • 167 citations

Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis.

1996 • 164 citations

Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes.

1996 • 159 citations

C-X-C and C-C chemokines are expressed in the cerebrospinal fluid in bacterial meningitis and mediate chemotactic activity on peripheral blood-derived polymorphonuclear and mononuclear cells in vitro.

1997 • 157 citations

Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8.

1997 • 154 citations

Chemokines and chemotaxis of leukocytes in infectious meningitis

1998 • 153 citations

CXC chemokines interleukin-8 (IL-8) and growth-related gene product α (GROα) modulate Purkinje neuron activity in mouse cerebellum

1998 • 148 citations

Expression of stromal cell-derived factor-1 and CXCR4 chemokine receptor mRNAs in cultured rat glial and neuronal cells

1998 • 133 citations

Macrophage inflammatory protein-1α in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological diseases

1995 • 133 citations

Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease.

1997 • 127 citations

Chemokine receptors in the human brain and their relationship to HIV infection

1998 • 126 citations

The Duffy antigen receptor for chemokines: structural analysis and expression in the brain

1996 • 121 citations

Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon‐γ inducible protein‐10 and monocyte chemotactic protein‐1

1997 • 110 citations

Prolonged Expression of Interferon‐Inducible Protein‐10 in Ischemic Cortex After Permanent Occlusion of the Middle Cerebral Artery in Rat

1998 • 108 citations

C10 Is a Novel Chemokine Expressed in Experimental Inflammatory Demyelinating Disorders that Promotes Recruitment of Macrophages to the Central Nervous System

1999 • 107 citations

Neuronal expression of fractalkine in the presence and absence of inflammation

1998 • 105 citations

Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells.

1996 • 103 citations

Chemokine expression in rat stab wound brain injury

1996 • 96 citations

Chemokines in the Cerebrospinal Fluid of Patients with Meningitis

1996 • 95 citations

Murine Astrocytes Express a Functional Chemokine Receptor

1997 • 82 citations

Emptying and refilling of Ca2+ store in tracheal myocytes as indicated by ACh-evoked currents and contraction

1993 • 79 citations

Time course of chemokines in the cerebrospinal fluid and serum during herpes simplex type 1 encephalitis

1998 • 78 citations

Chemokine receptors in HIV-1 infection of the central nervous system

1998 • 76 citations

Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor

1997 • 75 citations

Modulation of the neurotransmitter release in rat cerebellar neurons by GROβ

1998 • 74 citations

Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus

1999 • 71 citations

The G protein‐coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues

1993 • 67 citations

Differential chemokine induction by the mouse adenovirus type-1 in the central nervous system of susceptible and resistant strains of mice

1999 • 61 citations

MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo.

1995 • 57 citations

Recombinant Human Adenovirus with Rat MIP‐2 Gene Insertion Causes Prolonged PMN Recruitment to the Murine Brain

1996 • 49 citations

Rat LCR1: cloning and cellular distribution of a putative chemokine receptor in brain.

1996 • 45 citations

Cytokine and chemokine production in HSV-1 latently infected trigeminal ganglion cell cultures: Effects of hyperthermic stress

1998 • 37 citations

Fever and feeding: Differential actions of macrophage inflammatory protein-1 (MIP-1), MIP-1? and MIP-1? on rat hypothalamus

1993 • 36 citations

Central Actions of Interleukin-8 in the Rat are Independent of Prostaglandins

1990 • 33 citations

Hypothalamic interaction between macrophage inflammatory protein‐1 alpha (MIP‐1 alpha) and MIP‐1 beta in rats: a new level for fever control?

1996 • 32 citations

Chemokine-induced fever: intracerebroventricular actions of MIP-1 and MIP-1α in rats

1994 • 14 citations

Molecular cloning of a G protein-coupled receptor that is highly expressed in lymphocytes and proliferative areas of developing brain

1992 • 9 citations