gp120-Induced Neurotoxicity in Hippocampal Pyramidal Neuron Cultures: Protective Action of TGF-β1

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

The AIDS Dementia Complex

1988 • 1,387 citations

The AIDS dementia complex: II. Neuropathology

1986 • 1,280 citations

The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex

1988 • 1,244 citations

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1995 • 951 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice

1994 • 678 citations

Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide

1988 • 616 citations

HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists

1990 • 595 citations

Neocortical damage during HIV infection

1991 • 456 citations

Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons

1992 • 416 citations

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1995 • 403 citations

Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity

1991 • 397 citations

HIV‐1, macrophages, glial cells, and cytokines in AIDS nervous system disease

1991 • 359 citations

Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures.

1993 • 348 citations

Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS

1994 • 301 citations

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione

1994 • 268 citations

The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes.

1993 • 230 citations

Transforming Growth Factor-β₁ Prevents Glutamate Neurotoxicity in Rat Neocortical Cultures and Protects Mouse Neocortex from Ischemic Injury in vivo

1993 • 228 citations

Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type 1 envelope glycoprotein gp120.

1991 • 227 citations

Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons.

1994 • 225 citations

Rapid Loss of CD4 ⁺ T Cells in Human-PBL-SCID Mice by Noncytopathic HIV Isolates

1993 • 189 citations

Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity

1996 • 188 citations

gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine

1992 • 174 citations

Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

1996 • 163 citations

Excitotoxicity induced by enhanced excitatory neurotransmission in cultured hippocampal pyramidal neurons

1990 • 155 citations

Human immunodeficiency virus coat protein gp120 inhibits the beta-adrenergic regulation of astroglial and microglial functions.

1993 • 150 citations

Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex.

1994 • 148 citations

NMDA and Kainate Induce Internucleosomal DNA Cleavage Associated With Both Apoptotic and Necrotic Cell Death in the Neonatal Rat Brain

1995 • 130 citations

The Ca²⁺ influx induced by β‐amyloid peptide 25–35 in cultured hippocampal neurons results from network excitation

1995 • 123 citations

HIV‐1 Envelope Proteins gp120 and gp160 Potentiate NMDA‐induced [Ca²⁺]_i Increase, Alter [Ca²⁺]_i Homeostasis and Induce Neurotoxicity in Human Embryonic Neurons

1995 • 120 citations

Brain macrophages: neurotoxic or neurotrophic effector cells?

1994 • 113 citations

Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: A study with rat cerebellar granule cell cultures

1993 • 113 citations

Astroglial differentiation is required for support of neurite outgrowth

1994 • 80 citations

HIV-1 envelope protein evokes intracellular calcium oscillations in rat hippocampal neurons

1992 • 79 citations

Developmental regulation of the toxin sensitivity of Ca(2+)-permeable AMPA receptors in cortical glia

1996 • 66 citations

HIV-1 gp120 receptor on CD4-negative brain cells activates a tyrosine kinase

1992 • 54 citations

Exposure to gp120 of HIV‐1 Induces an Increased Release of Arachidonic Acid in Rat Primary Neuronal Cell Culture Followed by NMDA Receptor‐mediated Neurotoxicity

1995 • 54 citations

The gp 120 glycoprotein of human immunodeficiency virus type 1 binds to sensory ganglion neurons

1993 • 50 citations

β25–35 Alters Calcium Homeostasis and Induces Neurotoxicity in Cerebellar Granule Cells

1996 • 44 citations

HIV-gp120 activates large-conductance apamin-sensitive potassium channels in rat astrocytes

1995 • 33 citations

Ca2+, N-Methyl-d-Aspartate Receptors, and Aids-Related Neuronal Injury

1994 • 22 citations

Human Immunodeficiency Virus Type 1 Infection of Neonatal Severe Combined Immunodeficient Mice Xenografted with Human Cord Blood Cells

1994 • 15 citations

Beta-25–35 induces neurotoxicity by altering calcium homeostasis in cerebellar granule cells

1996 • 10 citations