Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

Construction of adenovirus vectors through Cre-lox recombination

1997 • 807 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia

1998 • 706 citations

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

1996 • 586 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

1998 • 537 citations

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1996 • 477 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

Aberrant Expression of Mitotic Cdc2/Cyclin B1 Kinase in Degenerating Neurons of Alzheimer’s Disease Brain

1997 • 444 citations

Cyclins and cyclin-dependent kinases: take your partners

1993 • 441 citations

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1997 • 417 citations

DNA damage and apoptosis in Alzheimer's disease: colocalization with c- Jun immunoreactivity, relationship to brain area, and effect of postmortem delay

1996 • 400 citations

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

1996 • 325 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

Cell cycle markers in the hippocampus in Alzheimer's disease

1997 • 315 citations

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity.

1996 • 301 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.

1997 • 284 citations

G1/S Cell Cycle Blockers and Inhibitors of Cyclin-Dependent Kinases Suppress Camptothecin-Induced Neuronal Apoptosis

1997 • 275 citations

Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons

1997 • 270 citations

Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle.

1998 • 270 citations

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

1993 • 267 citations

Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents

1998 • 264 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

Inhibitors of Cyclin-dependent Kinases Promote Survival of Post-mitotic Neuronally Differentiated PC12 Cells and Sympathetic Neurons

1996 • 252 citations

A Role for MAPK/ERK in Sympathetic Neuron Survival: Protection against a p53-Dependent, JNK-Independent Induction of Apoptosis by Cytosine Arabinoside

1999 • 243 citations

Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress

1998 • 243 citations

Role of Cell Cycle Regulatory Proteins in Cerebellar Granule Neuron Apoptosis

1999 • 238 citations

Ordering the Cell Death Pathway

1996 • 231 citations

E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization

1997 • 228 citations

Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support

1996 • 201 citations

Caspase-Dependent and -Independent Death of Camptothecin-Treated Embryonic Cortical Neurons

1999 • 200 citations

CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults

1999 • 192 citations

Apoptosis in neurodegenerative disorders

1997 • 171 citations

Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death

1997 • 170 citations

E2F-1:DP-1 Induces p53 and Overrides Survival Factors To Trigger Apoptosis

1995 • 167 citations

Apoptosis Decision Cascades and Neuronal Degeneration in Alzheimer’s Disease

1998 • 146 citations

Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G₁

1996 • 139 citations

Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.

1996 • 120 citations

Involvement of p53 in DNA Strand Break‐induced Apoptosis in Postmitotic CNS Neurons

1996 • 119 citations

Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity

1999 • 114 citations

Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons

1998 • 112 citations

The retinoblastoma gene product inhibits TGF-beta1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells.

1996 • 106 citations

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1995 • 96 citations

Induction of DNA synthesis and apoptosis in cardiac myocytes by E1A oncoprotein.

1996 • 93 citations

Retinoblastoma protein inhibits IFN-gamma induced apoptosis.

1996 • 71 citations

Induction of Cyclin B and H1 Kinase Activity in Apoptotic PC12 Cells

1995 • 64 citations

Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression.

1992 • 60 citations

Functional Interaction between DP-1 and p53

1996 • 56 citations

The interactions of E2F with pRB and with p107 are regulated via the phosphorylation of pRB and p107 by a cyclin-dependent kinase.

1995 • 47 citations

Dominant inhibitory Ras delays Sindbis virus-induced apoptosis in neuronal cells

1996 • 37 citations