Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Chemokines

1997 • 1,926 citations

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

1999 • 1,714 citations

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

1996 • 1,482 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

1997 • 1,078 citations

Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice

1998 • 1,022 citations

Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

1994 • 818 citations

Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1

1997 • 724 citations

Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins

1993 • 722 citations

Telomere Fluorescence Measurements in Granulocytes and T Lymphocyte Subsets Point to a High Turnover of Hematopoietic Stem Cells and Memory T Cells in Early Childhood

1999 • 719 citations

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

1998 • 642 citations

Requirement of Mip-1α for an Inflammatory Response to Viral Infection

1995 • 636 citations

Plasma elevation of stromal cell–derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells

2001 • 530 citations

The Effect of Differing Demands for Blood Cell Production on DNA Synthesis by Hemopoietic Colony-Forming Cells of Mice

1965 • 515 citations

Embryonic Expression and Function of the Chemokine SDF-1 and Its Receptor, CXCR4

1999 • 476 citations

Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia

1987 • 461 citations

Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes.

1994 • 460 citations

Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment.

1997 • 431 citations

Chemokine SDF-1 enhances circulating CD34+ cell proliferation in synergy with cytokines: possible role in progenitor survival

2000 • 365 citations

Host origin of marrow stromal cells following allogeneic bone marrow transplantation

1987 • 323 citations

Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells

1993 • 296 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues.

1995 • 288 citations

Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression.

1993 • 273 citations

Intracellular and Surface Expression of the HIV-1 Coreceptor CXCR4/Fusin on Various Leukocyte Subsets: Rapid Internalization and Recycling Upon Activation

1998 • 266 citations

Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV.

1992 • 263 citations

Chemotaxis of primitive hematopoietic cells in response to stromal cell–derived factor-1

2000 • 255 citations

Kinetic Evidence of the Regeneration of Multilineage Hematopoiesis From Primitive Cells in Normal Human Bone Marrow Transplanted Into Immunodeficient Mice

1997 • 247 citations

Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia

1999 • 243 citations

Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells

1990 • 236 citations

Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor

1996 • 234 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta

1990 • 227 citations

Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation.

1995 • 216 citations

The α-Chemokine Receptor CXCR4 Is Expressed on the Megakaryocytic Lineage From Progenitor to Platelets and Modulates Migration and Adhesion

1998 • 206 citations

Molecular Cloning of the cDNA and Chromosomal Localization of the Gene for a Putative Seven-Transmembrane Segment (7-TMS) Receptor Isolated from Human Spleen

1993 • 192 citations

Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells.

1986 • 191 citations

Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lymphohematopoietic progenitors

1999 • 188 citations

Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes.

1997 • 182 citations

Baillière's clinical haematology

1998 • 168 citations

CXCR-4 Desensitization Is Associated with Tissue Localization of Hemopoietic Progenitor Cells

2001 • 165 citations

N-terminal Peptides of Stromal Cell-derived Factor-1 with CXC Chemokine Receptor 4 Agonist and Antagonist Activities

1998 • 148 citations

High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations.

1996 • 147 citations

Regulated proliferation of primitive hematopoietic progenitor cells in long-term human marrow cultures

1985 • 144 citations

HCC-1, a novel chemokine from human plasma.

1996 • 136 citations

The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression

2000 • 127 citations

Chemokine Receptor CXCR4 Expression in Endothelium

1998 • 127 citations

Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells.

1993 • 125 citations

Selective secretion of chemoattractants for haemopoietic progenitor cells by bone marrow endothelial cells: a possible role in homing of haemopoietic progenitor cells to bone marrow

1999 • 123 citations

Sustained proliferation, multi‐lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood

1997 • 117 citations

A novel polypeptide secreted by activated human T lymphocytes.

1989 • 112 citations

Effects of CC, CXC, C, and CX₃C Chemokines on Proliferation of Myeloid Progenitor Cells, and Insights into SDF‐1‐Induced Chemotaxis of Progenitors^a

1999 • 110 citations

Stromal Derived Factor-1–Induced Chemokinesis of Cord Blood CD34+ Cells (Long-Term Culture-Initiating Cells) Through Endothelial Cells Is Mediated by E-Selectin

1999 • 107 citations

Cell cycle and functional differences between CD34+/CD38hi and CD34+/38lo human marrow cells after in vitro cytokine exposure

1995 • 100 citations

COMPARATIVE ANALYSIS OF THE HUMAN MACROPHAGE INFLAMMATORY PROTEIN FAMILY OF CYTOKINES (CHEMOKINES) ON PROLIFERATION OF HUMAN MYELOID PROGENITOR CELLS

1993 • 94 citations

Quantitation of the quiescent fraction of long-term culture-initiating cells in normal human blood and marrow and the kinetics of their growth factor-stimulated entry into S-phase in vitro

1995 • 89 citations

The BCR/ABL Oncogene Alters the Chemotactic Response to Stromal-Derived Factor-1

1999 • 84 citations

MCP-1, not MIP-1α, Is the Endogenous Chemokine That Cooperates With TGF-β to Inhibit the Cycling of Primitive Normal but not Leukemic (CML) Progenitors in Long-Term Human Marrow Cultures

1998 • 75 citations

Transforming growth factor‐β: A bidirectional regulator of hematopoietic cell growth

1992 • 66 citations

Cell culture studies in CML

1987 • 65 citations

Treatment of marrow stroma with interferon-alpha restores normal beta 1 integrin-dependent adhesion of chronic myelogenous leukemia hematopoietic progenitors. Role of MIP-1 alpha.

1995 • 62 citations

In vivo kinetic status of hematopoietic stem and progenitor cells as inferred from labeling with bromodeoxyuridine.

1984 • 59 citations

Direct contact with stroma inhibits proliferation of human long-term culture initiating cells.

1996 • 58 citations

Differentiation Stage–Specific Regulation of Primitive Human Hematopoietic Progenitor Cycling by Exogenous and Endogenous Inhibitors in an In Vivo Model

1999 • 57 citations

Activation of HIV-1 Coreceptor (CXCR4) Mediates Myelosuppression

1997 • 57 citations

BCR – ABL accelerates C2-ceramide-induced apoptosis

1998 • 53 citations

Purification of Hematopoietic Stem Cells for Further Biological Study

1999 • 50 citations

Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures

1991 • 50 citations

Expression of CD34 on human B cell precursors

1991 • 49 citations

The effects of interleukin 6 and interleukin 3 on early hematopoietic events in long-term cultures of human marrow.

1991 • 47 citations

Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures

1991 • 42 citations

TGF-beta and MIP-1 alpha exert their main inhibitory activity on very primitive CD34+2CD38- cells but show opposite effects on more mature CD34+CD38+ human hematopoietic progenitors.

1996 • 40 citations

Granulocyte-macrophage colony-stimulating factor modulation of the inhibitory effect of transforming growth factor-beta on normal and leukemic human hematopoietic progenitor cells.

1992 • 39 citations

Differential effects of microenvironmentally presented interleukin 3 versus soluble growth factor on primitive human hematopoietic cells.

1991 • 37 citations

Long-term culture of human bone marrow. I. characterization of adherent cells in flow cytometry.

1990 • 36 citations

Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines

2000 • 26 citations