SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model

SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

2005 • 1,804 citations

Production of transforming growth factor beta 1 during repair of arterial injury.

1991 • 539 citations

Contribution of Adventitial Fibroblasts to Neointima Formation and Vascular Remodeling

2001 • 488 citations

TGF-β signaling in vascular fibrosis

2007 • 469 citations

Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

1999 • 433 citations

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

1994 • 377 citations

Antibodies against transforming growth factor-beta 1 suppress intimal hyperplasia in a rat model.

1994 • 303 citations

Transforming Growth Factor-βs and Vascular Disorders

2006 • 249 citations

Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor

2004 • 246 citations

Roles of activin in tissue repair, fibrosis, and inflammatory disease

2006 • 207 citations

Soluble Transforming Growth Factor-β Type II Receptor Inhibits Negative Remodeling, Fibroblast Transdifferentiation, and Intimal Lesion Formation But Not Endothelial Growth

1999 • 197 citations

IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy

2006 • 191 citations

Inhibition of Gene Markers of Fibrosis with a Novel Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase in Puromycin-Induced Nephritis

2005 • 183 citations

Successful shape-Based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)

2003 • 161 citations

Inhibition of TGF‐β signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine‐induced liver fibrosis

2005 • 156 citations

SOME NEW STAINING METHODS OF WIDE APPLICABILITY.

1908 • 136 citations

Activin A Is a Potent Activator of Renal Interstitial Fibroblasts

2004 • 132 citations

Attenuation of Bleomycin-induced Pulmonary Fibrosis by Follistatin

2005 • 104 citations

Discovery of 4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): A Potent, Selective, and Orally Active Transforming Growth Factor-β Type I Receptor Inhibitor

2006 • 100 citations

Understanding the role of transforming growth factor-β1 in intimal thickening after vascular injury

2007 • 100 citations

Transforming Growth Factor-Beta-Dependent Events in Vascular Remodeling following Arterial Injury

2003 • 96 citations

Expression of activin A is increased in cirrhotic and fibrotic rat livers

1998 • 92 citations

Role of p38 Mitogen-Activated Protein Kinase in Neointimal Hyperplasia After Vascular Injury

2000 • 92 citations

Inhibition of activin receptor-like kinase 5 attenuates Bleomycin-induced pulmonary fibrosis

2006 • 91 citations

Intracellular TGF-β Receptor Blockade Abrogates Smad-Dependent Fibroblast Activation In Vitro and In Vivo

2006 • 88 citations

The Dependence of Transforming Growth Factor-β-Induced Collagen Production on Autocrine Factor Activin A in Hepatic Stellate Cells

2004 • 80 citations

Expression of immunoreactive activin A protein in remodeling lesions associated with interstitial pulmonary fibrosis.

1996 • 78 citations

Transforming Growth Factor-β Receptor Type 1 (TGFβRI) Kinase Activity but Not p38 Activation Is Required for TGFβRI-Induced Myofibroblast Differentiation and Profibrotic Gene Expression

2006 • 74 citations

Targeted Disruption of TGF-β–Smad3 Signaling Leads to Enhanced Neointimal Hyperplasia With Diminished Matrix Deposition in Response to Vascular Injury

2005 • 73 citations

Mini ReviewActivin Receptor Signaling

2004 • 65 citations

Effect of Transforming Growth Factor-β Receptor I Kinase Inhibitor 2,4-Disubstituted Pteridine (SD-208) in Chronic Allergic Airway Inflammation and Remodeling

2006 • 62 citations

Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo.

1997 • 61 citations

Smad7 Gene Transfer Attenuates Adventitial Cell Migration and Vascular Remodeling After Balloon Injury

2005 • 57 citations

Local Expression of Bovine Decorin by Cell-Mediated Gene Transfer Reduces Neointimal Formation After Balloon Injury in Rats

2000 • 56 citations

Differential effect of activin A and BMP-7 on myofibroblast differentiation and the role of the Smad signaling pathway.

2002 • 52 citations

Sustained Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Vascular Response to Injury

2002 • 50 citations

TGF-β1 Expression in Renal Allograft Rejection and Cyclosporine A Toxicity

2005 • 43 citations

Antisense to transforming growth factor-β1 messenger RNA reduces vein graft intimal hyperplasia and monocyte chemotactic protein 1

2005 • 42 citations

TGFβ is active, and correlates with activators of TGFβ, following porcine coronary angioplasty

2001 • 37 citations

Novel cardiovascular actions of the activins

1999 • 34 citations

Glomerular activin A overexpression is linked to fibrosis in anti-Thy1 glomerulonephritis

2005 • 33 citations

Effect of TGF-β<sub>1</sub> Antisense S-Oligonucleotide on Synthesis and Accumulation of Matrix Proteoglycans in Balloon Catheter-Injured Neointima of Rabbit Carotid Arteries

2000 • 33 citations

Potential contribution of bone marrow-derived precursors to vascular repair and lesion formation: lessons from animal models of vascular diseases

2007 • 28 citations

Chimeric DNA–RNA hammerhead ribozyme targeting transforming growth factor-β1 mRNA inhibits neointima formation in rat carotid artery after balloon injury

2003 • 28 citations

Contribution of Mesenchymal Progenitor Cells to Tissue Repair in Rat Cardiac Allografts Undergoing Chronic Rejection

2005 • 22 citations

The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology

2008 • 8 citations