Abscopal Regression of Antigen Disparate Tumors by Antigen Cascade After Systemic Tumor Vaccination in Combination with Local Tumor Radiation

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody

2009 • 1,480 citations

Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated

2004 • 1,253 citations

Whole Body Irradiation—Radiobiology or Medicine?

1953 • 1,004 citations

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

1999 • 973 citations

Systemic effects of local radiotherapy

2009 • 906 citations

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

2004 • 532 citations

Irradiation of Tumor Cells Up-Regulates Fas and Enhances CTL Lytic Activity and CTL Adoptive Immunotherapy

2003 • 452 citations

Induction of Tumor Cell Apoptosis In Vivo Increases Tumor Antigen Cross-Presentation, Cross-Priming Rather than Cross-Tolerizing Host Tumor-Specific CD8 T Cells

2003 • 441 citations

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

2000 • 440 citations

External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

2004 • 425 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.

1996 • 386 citations

Combining a Recombinant Cancer Vaccine with Standard Definitive Radiotherapy in Patients with Localized Prostate Cancer

2005 • 373 citations

[Whole body irradiation].

1992 • 364 citations

Phase I Study in Advanced Cancer Patients of a Diversified Prime-and-Boost Vaccination Protocol Using Recombinant Vaccinia Virus and Recombinant Nonreplicating Avipox Virus to Elicit Anti–Carcinoembryonic Antigen Immune Responses

2000 • 363 citations

Workshop R: Tumor Immunology, Abstract R1 bis R30

2001 • 312 citations

A triad of costimulatory molecules synergize to amplify T-cell activation.

1999 • 293 citations

Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis

1998 • 266 citations

Radiation abscopal antitumor effect is mediated through p53.

2003 • 243 citations

Role of Fas-mediated cell death in the regulation of immune responses

1996 • 243 citations

The controversial abscopal effect

2005 • 225 citations

Diversified prime and boost protocols using recombinant vaccinia virus and recombinant non-replicating avian pox virus to enhance T-cell immunity and antitumor responses

1997 • 209 citations

Radiation-Induced Bystander Effects: What Are They, and How Relevant Are They to Human Radiation Exposures?

2011 • 202 citations

Immune Modulation by Ionizing Radiation and its Implications for Cancer Immunotherapy

2002 • 200 citations

Standard Treatments Induce Antigen-Specific Immune Responses in Prostate Cancer

2007 • 167 citations

Enhancing Efficacy of Recombinant Anticancer Vaccines With Prime/Boost Regimens That Use Two Different Vectors

1997 • 158 citations

Transduction and expression of the human carcinoembryonic antigen gene in a murine colon carcinoma cell line.

1991 • 149 citations

Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern.

1994 • 135 citations

Granulocyte/macrophage-colony stimulating factor produced by recombinant avian poxviruses enriches the regional lymph nodes with antigen-presenting cells and acts as an immunoadjuvant.

2001 • 126 citations

Fas-Mediated Apoptosis

1996 • 118 citations

Enhanced Activation of T Cells by Dendritic Cells Engineered to Hyperexpress a Triad of Costimulatory Molecules

2000 • 97 citations

Irradiation induced expression of CD31, ICAM-1 and VCAM-1 in human microvascular endothelial cells.

2000 • 95 citations

Prerequisites for the Antitumor Vaccine-Like Effect of Chemotherapy and Radiotherapy

2011 • 90 citations

MHC class I-restricted epitope spreading in the context of tumor rejection following vaccination with a single immunodominant CTL epitope

1999 • 86 citations

Combination Chemotherapy and Radiation of Human Squamous Cell Carcinoma of the Head and Neck Augments CTL-Mediated Lysis

2006 • 85 citations

Costimulation Enhances the Active Immunotherapy Effect of Recombinant Anticancer Vaccines

1996 • 84 citations

Desirable cell death during anticancer chemotherapy

2010 • 78 citations

Mechanisms of Peripheral T Cell Tolerance

2007 • 70 citations

The Envelope Protein of an Endogenous Murine Retrovirus Is a Tumor-Associated T-Cell Antigen for Multiple Murine Tumors

2000 • 64 citations

Intratumoral injection of interleukin‐2 augments the local and abscopal effects of radiotherapy in murine rectal cancer

2011 • 63 citations

Effect of a small molecule BCL‐2 inhibitor on immune function and use with a recombinant vaccine

2010 • 44 citations

Identification of an interferon-gamma-inducible carcinoembryonic antigen (CEA) CD8(+) T-cell epitope, which mediates tumor killing in CEA transgenic mice.

2002 • 43 citations

Irradiation Induces Upregulation of CD31 in Human Endothelial Cells

1999 • 42 citations

The cytotoxic T-lymphocyte response against a poorly immunogenic mammary adenocarcinoma is focused on a single immunodominant class I epitope derived from the gp70 Env product of an endogenous retrovirus.

2003 • 42 citations

Characterization of CD8 + cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant

2001 • 39 citations

A wild‐type p53 cytotoxic T cell epitope is presented by mouse hepatocarcinoma cells

1996 • 22 citations

Remodeling of the tumor microenvironment by combined treatment with a novel radiosensitizer, {alpha}-sulfoquinovosylmonoacylglycerol ({alpha}-SQMG) and X-irradiation.

2010 • 13 citations