Biological Basket Weaving: Formation and Function of Clathrin-Coated Vesicles

The Protein Data Bank

2000 • 35,287 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

The Hsp70 and Hsp60 Chaperone Machines

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Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

THE CAVEOLAE MEMBRANE SYSTEM

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Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

YOLK PROTEIN UPTAKE IN THE OOCYTE OF THE MOSQUITO AEDES AEGYPTI. L

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Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

1998 • 1,012 citations

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

1995 • 955 citations

Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation.

1989 • 920 citations

Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling

1999 • 825 citations

Specificity within the EGF family/ErbB receptor family signaling network

1998 • 804 citations

The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast

1999 • 753 citations

Simultaneous Binding of PtdIns(4,5)P ₂ and Clathrin by AP180 in the Nucleation of Clathrin Lattices on Membranes

2001 • 719 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Dynamin and Its Role in Membrane Fission

2000 • 689 citations

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

1977 • 688 citations

Altered Trafficking of Lysosomal Proteins in Hermansky-Pudlak Syndrome Due to Mutations in the β3A Subunit of the AP-3 Adaptor

1999 • 663 citations

A Structural Explanation for the Recognition of Tyrosine-Based Endocytotic Signals

1998 • 582 citations

Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis

1998 • 576 citations

Acute cholesterol depletion inhibits clathrin-coated pit budding

1999 • 576 citations

Coated vesicles from pig brain: Purification and biochemical characterization

1975 • 564 citations

The Structural Era of Endocytosis

1999 • 560 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

Three ways to make a vesicle

2000 • 547 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

Developmental selection of var gene expression in Plasmodium falciparum

1998 • 532 citations

Clathrin

2000 • 528 citations

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

1993 • 516 citations

Accessory factors in clathrin-dependent synaptic vesicle endocytosis

2000 • 513 citations

Interleukin 2 Receptors and Detergent-Resistant Membrane Domains Define a Clathrin-Independent Endocytic Pathway

2001 • 513 citations

A Novel Clathrin Adaptor Complex Mediates Basolateral Targeting in Polarized Epithelial Cells

1999 • 509 citations

Adaptors for Clathrin-Mediated Traffic

1999 • 500 citations

Role of auxilin in uncoating clathrin-coated vesicles

1995 • 495 citations

Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling

1994 • 483 citations

Role of the ENTH Domain in Phosphatidylinositol-4,5-Bisphosphate Binding and Endocytosis

2001 • 466 citations

GTPase activity of dynamin and resulting conformation change are essential for endocytosis

2001 • 451 citations

Clathrin-coated vesicles: Isolation, dissociation and factor-dependent reassociation of clathrin baskets

1979 • 450 citations

An enzyme that removes clathrin coats: purification of an uncoating ATPase.

1984 • 449 citations

THE "VESICLE IN A BASKET"

1969 • 445 citations

Spatial control of coated-pit dynamics in living cells

1999 • 435 citations

The AP-3 Adaptor Complex Is Essential for Cargo-Selective Transport to the Yeast Vacuole

1997 • 430 citations

Molecular Links between Endocytosis and the Actin Cytoskeleton

2000 • 417 citations

μ1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors

2000 • 408 citations

A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals.

1996 • 408 citations

Ggas

2000 • 399 citations

The J-domain family and the recruitment of chaperone power

1998 • 396 citations

AP-3: an adaptor-like protein complex with ubiquitous expression

1997 • 389 citations

Actin Assembly Plays a Variable, but not Obligatory Role in Receptor‐Mediated Endocytosis

2000 • 385 citations

Association of the AP-3 Adaptor Complex with Clathrin

1998 • 384 citations

Membrane traffic in polarized epithelial cells

2000 • 384 citations

The SH3p4/Sh3p8/SH3p13 protein family: Binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain

1997 • 383 citations

The Interaction of β-Arrestin with the AP-2 Adaptor Is Required for the Clustering of β2-Adrenergic Receptor into Clathrin-coated Pits

2000 • 374 citations

PACS-1 Defines a Novel Gene Family of Cytosolic Sorting Proteins Required for trans-Golgi Network Localization

1998 • 372 citations

Characterization of the Adaptor-related Protein Complex, AP-3

1997 • 369 citations

A novel class of clathrin-coated vesicles budding from endosomes.

1996 • 369 citations

On the Dynamics of TCR:CD3 Complex Cell Surface Expression and Downmodulation

2000 • 364 citations

Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: Effects of brefeldin A and G protein activators

1992 • 358 citations

BIN1 is a novel MYC–interacting protein with features of a tumour suppressor

1996 • 358 citations

Numb Is an Endocytic Protein

2000 • 357 citations

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1989 • 356 citations

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

1998 • 353 citations

Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.

1991 • 352 citations

EGF Receptor Signaling Stimulates SRC Kinase Phosphorylation of Clathrin, Influencing Clathrin Redistribution and EGF Uptake

1999 • 347 citations

Caveolin-3 Associates with Developing T-tubules during Muscle Differentiation

1997 • 345 citations

AP-2/Eps15 Interaction Is Required for Receptor-mediated Endocytosis

1998 • 345 citations

The dynamin family of mechanoenzymes: pinching in new places

2000 • 345 citations

Phosphoinositides in membrane traffic at the synapse

2001 • 334 citations

Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature-sensitive mutant of Drosophila melanogaster, shibirets1.

1983 • 332 citations

Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores

1997 • 329 citations

A Family of Proteins with γ-Adaptin and Vhs Domains That Facilitate Trafficking between the Trans-Golgi Network and the Vacuole/Lysosome

2000 • 323 citations

Wild-Type and Mutant Huntingtins Function in Vesicle Trafficking in the Secretory and Endocytic Pathways

1998 • 322 citations

Clathrin Assembly Lymphoid Myeloid Leukemia (CALM) Protein: Localization in Endocytic-coated Pits, Interactions with Clathrin, and the Impact of Overexpression on Clathrin-mediated Traffic

1999 • 317 citations

Role of coated vesicles, microfilaments, and calmodulin in receptor-mediated endocytosis by cultured B lymphoblastoid cells.

1980 • 315 citations

Regulated Migration of Epidermal Growth Factor Receptor from Caveolae

1999 • 314 citations

Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site

1998 • 310 citations

Characterization of a Fourth Adaptor-related Protein Complex

1999 • 309 citations

Syndapin Isoforms Participate in Receptor-Mediated Endocytosis and Actin Organization

2000 • 309 citations

Biochemical dissection of AP-1 recruitment onto Golgi membranes.

1993 • 308 citations

end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae.

1995 • 305 citations

Living with Clathrin: Its Role in Intracellular Membrane Traffic

1988 • 304 citations

Phosphoinositide–Ap-2 Interactions Required for Targeting to Plasma Membrane Clathrin-Coated Pits

1999 • 304 citations

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

2000 • 301 citations

The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.

1996 • 300 citations

Syndapin I, a Synaptic Dynamin-binding Protein that Associates with the Neural Wiskott-Aldrich Syndrome Protein

1999 • 299 citations

AP-4, a Novel Protein Complex Related to Clathrin Adaptors

1999 • 292 citations

Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains

1998 • 291 citations

Arrestin/Clathrin Interaction

1997 • 290 citations

PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions

1998 • 289 citations

A Primer on Vesicle Budding

1999 • 288 citations

Peptide-in-groove interactions link target proteins to the β-propeller of clathrin

2000 • 285 citations

A Structural Explanation for the Binding of Multiple Ligands by the α-Adaptin Appendage Domain

1999 • 284 citations

A Novel Motor, KIF13A, Transports Mannose-6-Phosphate Receptor to Plasma Membrane through Direct Interaction with AP-1 Complex

2000 • 276 citations

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

1999 • 275 citations

A novel role for Rab5–GDI in ligand sequestration into clathrin-coated pits

1998 • 273 citations

The clathrin endocytic pathway in viral infection

1998 • 271 citations

The GGAs Promote ARF-Dependent Recruitment of Clathrin to the TGN

2001 • 268 citations

Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis

1999 • 265 citations

Mutations in Synaptojanin Disrupt Synaptic Vesicle Recycling

2000 • 262 citations

Interaction of Activated EGF Receptors with Coated Pit Adaptins

1993 • 259 citations

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

1999 • 259 citations

A Family of ADP-Ribosylation Factor Effectors That Can Alter Membrane Transport through thetrans-Golgi

2000 • 257 citations

μ1B, a novel adaptor medium chain expressed in polarized epithelial cells¹

1999 • 249 citations

The amphiphysin family of proteins and their role in endocytosis at the synapse

1998 • 246 citations

Interactions between HIV1 Nef and Vacuolar ATPase Facilitate the Internalization of CD4

1998 • 245 citations

Amphiphysin II (SH3P9; BIN1), a Member of the Amphiphysin/Rvs Family, Is Concentrated in the Cortical Cytomatrix of Axon Initial Segments and Nodes of Ranvier in Brain and around T Tubules in Skeletal Muscle

1997 • 243 citations

A novel adaptor-related protein complex.

1996 • 241 citations

Domain structure and intramolecular regulation of dynamin GTPase

1997 • 239 citations

Kinesin and dynamin are required for post-Golgi transport of a plasma-membrane protein

2000 • 239 citations

The AP-3 complex: a coat of many colours

1998 • 237 citations

The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15

1999 • 236 citations

The structure and function of the beta2-adaptin appendage domain

2000 • 232 citations

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

1998 • 232 citations

Effects of cytoplasmic acidification on clathrin lattice morphology.

1989 • 232 citations

Membrane rafts and signaling by the multichain immune recognition receptors

2000 • 226 citations

Atomic Structure of Clathrin

1998 • 224 citations

Cloning of ligand targets: Systematic isolation of SH3 domain-containing proteins

1996 • 224 citations

In Polarized MDCK Cells Basolateral Vesicles Arise from Clathrin-γ-adaptin–coated Domains on Endosomal Tubules

1998 • 220 citations

Pan1p, Yeast eps15, Functions as a Multivalent Adaptor That Coordinates Protein–Protein Interactions Essential for Endocytosis

1998 • 220 citations

Defining protein interactions with yeast actin in vivo

1995 • 220 citations

The Class II Phosphoinositide 3-Kinase C2α Is Activated by Clathrin and Regulates Clathrin-Mediated Membrane Trafficking

2001 • 217 citations

An Actin-Binding Protein of the Sla2/Huntingtin Interacting Protein 1 Family Is a Novel Component of Clathrin-Coated Pits and Vesicles

1999 • 217 citations

Garrotes, Springs, Ratchets, and Whips: Putting Dynamin Models to the Test

2000 • 215 citations

Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant μ2 subunit and its effects on endocytosis

1999 • 212 citations

Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding

1999 • 211 citations

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the chain of adaptor complexes

1998 • 209 citations

Arrestin/Clathrin Interaction

1997 • 209 citations

Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms

1998 • 208 citations

Dap160, a Neural-specific Eps15 Homology and Multiple SH3 Domain-containing Protein That Interacts with DrosophilaDynamin

1998 • 205 citations

A Test of Clathrin Function in Protein Secretion and Cell Growth

1985 • 202 citations

All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis

2000 • 200 citations

A Clathrin-binding Site in the Hinge of the β2 Chain of Mammalian AP-2 Complexes

1995 • 197 citations

Genetic dissection of sperm individualization in Drosophila melanogaster

1998 • 194 citations

AP-2 Recruitment to Synaptotagmin Stimulated by Tyrosine-Based Endocytic Motifs

1999 • 193 citations

Amphiphysin, a novel protein associated with synaptic vesicles.

1992 • 192 citations

The Epsins Define a Family of Proteins That Interact with Components of the Clathrin Coat and Contain a New Protein Module

1999 • 186 citations

Recruitment of an alternatively spliced form of synaptojanin 2to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein

1999 • 183 citations

Crystal structure of the α appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly

1999 • 180 citations

The role of endosomes and lysosomes in MHC class II functioning

1998 • 179 citations

The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factor.

1996 • 178 citations

Identification and Characterization of a Nerve Terminal-enriched Amphiphysin Isoform

1997 • 176 citations

Crystal Structure of the Cytosolic C2a-C2b Domains of Synaptotagmin III

1999 • 174 citations

Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation

2000 • 171 citations

Identification of the Major Synaptojanin-binding Proteins in Brain

1997 • 169 citations

Adaptor Complex-independent Clathrin Function in Yeast

1999 • 167 citations

Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation

1998 • 167 citations

Differential Sorting of Lysosomal Enzymes Out of the Regulated Secretory Pathway in Pancreatic β-Cells

1997 • 166 citations

Protein traffic in the yeast endocytic and vacuolar protein sorting pathways

1998 • 164 citations

High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70 1 1Edited by P. E. Wright

1999 • 163 citations

Deep-etch visualization of proteins involved in clathrin assembly.

1988 • 163 citations

Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs

1995 • 163 citations

A Functional Phosphatidylinositol 3,4,5-Trisphosphate/Phosphoinositide Binding Domain in the Clathrin Adaptor AP-2 α Subunit. IMPLICATIONS FOR THE ENDOCYTIC PATHWAY

1996 • 162 citations

Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis

1990 • 159 citations

Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)

2000 • 158 citations

In vivo phosphorylation of adaptors regulates their interaction with clathrin.

1996 • 157 citations

The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components.

1993 • 157 citations

Folding and trimerization of clathrin subunits at the triskelion hub

1992 • 157 citations

Dominant-Interfering Hsc70 Mutants Disrupt Multiple Stages of the Clathrin-Coated Vesicle Cycle in Vivo

2001 • 154 citations

Clathrin: A Role in the Intracellular Retention of a Golgi Membrane Protein

1989 • 154 citations

A Selective Transport Route from Golgi to Late Endosomes That Requires the Yeast Gga Proteins

2000 • 152 citations

Role of Cyclin G-associated Kinase in Uncoating Clathrin-coated Vesicles from Non-neuronal Cells

2000 • 152 citations

Auxilin, a newly identified clathrin-associated protein in coated vesicles from bovine brain.

1990 • 152 citations

Clathrin facilitates the internalization of seven transmembrane segment receptors for mating pheromones in yeast.

1993 • 151 citations

β-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein

1995 • 150 citations

Adp-Ribosylation Factor 6 and Endocytosis at the Apical Surface of Madin-Darby Canine Kidney Cells

1999 • 150 citations

A Conserved Clathrin Assembly Motif Essential for Synaptic Vesicle Endocytosis

2000 • 150 citations

Clathrin self-assembly is mediated by a tandemly repeated superhelix

1999 • 147 citations

Stonin 2

2001 • 144 citations

Epsin Binds to Clathrin by Associating Directly with the Clathrin-terminal Domain

2000 • 143 citations

Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast

1999 • 143 citations

Clathrin coats at 21Aresolution: a cellular assembly designed to recycle multiple membrane receptors

1998 • 142 citations

γ-Synergin

1999 • 140 citations

Synaptojanin Forms Two Separate Complexes in the Nerve Terminal

1997 • 138 citations

A Dominant-negative Clathrin Mutant Differentially Affects Trafficking of Molecules with Distinct Sorting Motifs in the Class II Major Histocompatibility Complex (MHC) Pathway

1998 • 135 citations

AP-2-containing clathrin coats assemble on mature lysosomes.

1996 • 132 citations

Sac phosphatase domain proteins

2000 • 132 citations

NGF Signals through TrkA to Increase Clathrin at the Plasma Membrane and Enhance Clathrin-Mediated Membrane Trafficking

2000 • 131 citations

Human transferrin receptor internalization is partially dependent upon an aromatic amino acid on the cytoplasmic domain.

1990 • 130 citations

Lipid regulators of membrane traffic through the Golgi complex

1999 • 127 citations

Early Embryonic Death of Mice Deficient in γ-Adaptin

1999 • 127 citations

The Role of Dynamin and Its Binding Partners in Coated Pit Invagination and Scission

2001 • 127 citations

Tandem Arrangement of the Clathrin and AP-2 Binding Domains in Amphiphysin 1 and Disruption of Clathrin Coat Function by Amphiphysin Fragments Comprising These Sites

2000 • 126 citations

Deep-etch views of clathrin assemblies

1985 • 126 citations

DNM1, a dynamin-related gene, participates in endosomal trafficking in yeast.

1995 • 126 citations

Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein

1993 • 124 citations

Transferrin receptors promote the formation of clathrin lattices

1991 • 122 citations

GAK: a cyclin G associated kinase contains a tensin/auxilin‐like domain¹

1997 • 122 citations

Structure and Asn-Pro-Phe Binding Pocket of the Eps15 Homology Domain

1998 • 122 citations

Lipids, lipid modification and lipid–protein interaction in membrane budding and fission — insights from the roles of endophilin A1 and synaptophysin in synaptic vesicle endocytosis

2000 • 122 citations

AP180 and AP-2 Interact Directly in a Complex That Cooperatively Assembles Clathrin

1999 • 121 citations

Crystal structure of the pleckstrin homology domain from dynamin

1994 • 120 citations

Functional Organization of Clathrin in Coats

1999 • 114 citations

Saturation of the Endocytic Pathway for the Transferrin Receptor Does Not Affect the Endocytosis of the Epidermal Growth Factor Receptor

1997 • 113 citations

A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole

1998 • 112 citations

Traffic COPs of the Early Secretory Pathway

2000 • 112 citations

Tyrosine phosphorylation is required for actin-based motility of vaccinia but not Listeria or Shigella

1999 • 112 citations

Dissociation of Functional Roles of Dynamin in Receptor-mediated Endocytosis and Mitogenic Signal Transduction

1999 • 112 citations

Expression of auxilin or AP180 inhibits endocytosis by mislocalizing clathrin: evidence for formation of nascent pits containing AP1 or AP2 but not clathrin

2001 • 110 citations

100-kD proteins of Golgi- and trans-Golgi network-associated coated vesicles have related but distinct membrane binding properties

1992 • 109 citations

The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae.

1996 • 109 citations

Coupled Inositide Phosphorylation and Phospholipase D Activation Initiates Clathrin-coat Assembly on Lysosomes

1999 • 108 citations

Evidence That Dynamin-2 Functions as a Signal-Transducing Gtpase

2000 • 107 citations

Clathrin uncoating: Auxilin comes to life

2001 • 104 citations

A novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis

1993 • 104 citations

Ankyrins

2000 • 104 citations

Endocytosis proteins and cancer: a potential link?

1998 • 103 citations

Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits.

1993 • 102 citations

GLUT4 – At the Cross Roads Between Membrane Trafficking and Signal Transduction

2001 • 102 citations

Binding of AP-1 Golgi adaptors to membranes requires phosphorylated cytoplasmic domains of the mannose 6-phosphate/insulin-like growth factor II receptor.

1993 • 101 citations

The Leucine-based Sorting Motifs in the Cytoplasmic Domain of the Invariant Chain Are Recognized by the Clathrin Adaptors AP1 and AP2 and their Medium Chains

1999 • 101 citations

Molecular mechanism of NPF recognition by EH domains.

2000 • 100 citations

A Role for the Clathrin Assembly Domain of AP180 in Synaptic Vesicle Endocytosis

1999 • 100 citations

Characterization of a new member of the human /-adaptin gene family from chromosome 22q12, a candidate meningioma gene

1994 • 99 citations

Epidermal growth factor pathway substrate 15, Eps15

1999 • 98 citations

Energetics of Clathrin Basket Assembly

2001 • 97 citations

Adaptor γ Ear Homology Domain Conserved in γ-Adaptin and GGA Proteins That Interact with γ-Synergin

2000 • 97 citations

Synaptotagmins in membrane traffic: Which vesicles do the tagmins tag?

2000 • 96 citations

Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Engagement Delivers an Inhibitory Signal through the Membrane-Proximal Region in the Absence of the Tyrosine Motif in the Cytoplasmic Tail

1999 • 96 citations

Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics

1991 • 94 citations

Clathrin-coated pits contain an integral membrane protein that binds the AP-2 subunit with high affinity.

1990 • 93 citations

Clathrin self-assembly is regulated by three light-chain residues controlling the formation of critical salt bridges

1998 • 92 citations

The LDL Receptor Clustering Motif Interacts with the Clathrin Terminal Domain in a Reverse Turn Conformation

1998 • 92 citations

ATP- and Cytosol-dependent Release of Adaptor Proteins from Clathrin-coated Vesicles: A Dual Role for Hsc70

1998 • 91 citations

Intersectin 2, a new multimodular protein involved in clathrin‐mediated endocytosis

2000 • 91 citations

SCAMP1 Function in Endocytosis

2000 • 91 citations

Clathrin heavy chain: molecular cloning and complete primary structure.

1987 • 90 citations

A Novel All Helix Fold of the AP180 Amino-Terminal Domain for Phosphoinositide Binding and Clathrin Assembly in Synaptic Vesicle Endocytosis

2001 • 87 citations

A Di-leucine Signal in the Ubiquitin Moiety

2000 • 86 citations

Cytosolic and Membrane-associated Proteins Involved in the Recruitment of AP-1 Adaptors onto the Trans-Golgi Network

1996 • 84 citations

Clathrin: Its Role in Receptor-Mediated Vesicular Transport and Specialized Functions in Neurons

1993 • 84 citations

Synaptotagmin Regulation of Coated Pit Assembly

2000 • 83 citations

Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor

1999 • 81 citations

Protease-activated Receptor-1 Down-regulation

2000 • 81 citations

Predominance of clathrin light chain LCb correlates with the presence of a regulated secretory pathway.

1990 • 80 citations

Inositol lipid 5-phosphatases-traffic signals and signal traffic

1997 • 80 citations

Direct interaction of the 170 kDa isoform of synaptojanin 1 with clathrin and with the clathrin adaptor AP-2

2000 • 78 citations

Eps15R Is a Tyrosine Kinase Substrate with Characteristics of a Docking Protein Possibly Involved in Coated Pits-mediated Internalization

1998 • 78 citations

Amphiphysin IIm, a Novel Amphiphysin II Isoform, Is Required for Macrophage Phagocytosis

2000 • 77 citations

Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome

1999 • 77 citations

Direct and GTP-dependent Interaction of ADP-ribosylation Factor 1 with Clathrin Adaptor Protein AP-1 on Immature Secretory Granules

2000 • 77 citations

Interaction of the Bovine Papillomavirus E6 Protein with the Clathrin Adaptor Complex AP-1

1998 • 76 citations

5-HT and cAMP induce the formation of coated pits and vesicles and increase the expression of clathrin light chain in sensory neurons of aplysia

1993 • 76 citations

Parallel Dimers and Anti-parallel Tetramers Formed by Epidermal Growth Factor Receptor Pathway Substrate Clone 15 (EPS15)

1997 • 76 citations

Binding of AP2 to Sorting Signals Is Modulated by AP2 Phosphorylation

2001 • 75 citations

PACSIN 2, a novel member of the PACSIN family of cytoplasmicadapter proteins¹

1999 • 69 citations

A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network

2001 • 67 citations

Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein

2000 • 66 citations

Growth Hormone Receptor Ubiquitination Coincides with Recruitment to Clathrin-coated Membrane Domains

2001 • 66 citations

A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70

1997 • 65 citations

Inhibition of Phospholipase D by Amphiphysins

2000 • 64 citations

A Requirement for Ankyrin Binding to Clathrin during Coated Pit Budding

1999 • 62 citations

Clathrin in mitotic spindles

2000 • 59 citations

Floating the Raft Hypothesis for Immune Receptors: Access to Rafts Controls Receptor Signaling and Trafficking

2001 • 59 citations

Complete Reconstitution of Clathrin Basket Formation with Recombinant Protein Fragments: Adaptor Control of Clathrin Self‐Assembly

2000 • 58 citations

T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: Evidence for a protein kinase C‐independent staurosporine‐sensitive step

1991 • 57 citations

Nef—an adaptor adaptor?

1998 • 56 citations

Deep-etch visualization of 27S clathrin: a tetrahedral tetramer.

1987 • 56 citations

Clathrin plays a novel role in the regulation of cell polarity, pseudopod formation, uropod stability and motility in Dictyostelium

2000 • 55 citations

Self-association of the plasma membrane-associated clathrin assembly protein AP-2

1991 • 52 citations

Endocytosis: An assembly protein for clathrin cages

1999 • 52 citations

Cutting Edge: SIV Nef Protein Utilizes Both Leucine- and Tyrosine-Based Protein Sorting Pathways for Down-Regulation of CD4

1999 • 50 citations

Disruption of the Clathrin Heavy Chain-Like Gene (CLTCL) Associated with Features of DGS/VCFS: A Balanced (21;22)(p12;q11) Translocation

1997 • 49 citations

FAP52, a Novel, SH3 Domain-containing Focal Adhesion Protein

1997 • 49 citations

Clathrin Function in Yeast Endocytosis

2001 • 49 citations

Comparative Sequence Analysis of 634 kb of the Mouse Chromosome 16 Region of Conserved Synteny with the Human Velocardiofacial Syndrome Region on Chromosome 22q11.2

2000 • 48 citations

Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry

1999 • 48 citations

Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor

2001 • 45 citations

Pathways for Lipid Antigen Presentation by CD1 Molecules: Nowhere for Intracellular Pathogens to Hide

2000 • 45 citations

A Third Specificity‐Determining Site in μ2 Adaptin for Sequences Upstream of YxxΦ Sorting Motifs

2001 • 44 citations

Endocytic Clathrin-coated Pit Formation Is Independent of Receptor Internalization Signal Levels

1998 • 43 citations

Spatially Regulated Recruitment of Clathrin to the Plasma Membrane during Capping and Cell Translocation

2000 • 43 citations

Immunoelectron microscopic evidence for the extended conformation of light chains in clathrin trimers

1993 • 42 citations

Clathrin proteins and recognition memory

1997 • 41 citations

Sac phosphatase domain proteins

2000 • 39 citations

Clathrin Hub Expression Affects Early Endosome Distribution with Minimal Impact on Receptor Sorting and Recycling

2001 • 39 citations

The interaction between EEN and Abi-1, two MLLfusion partners, and synaptojanin and dynamin: implications for leukaemogenesis

2000 • 38 citations

Reconstitution of Clathrin‐Independent Endocytosis at the Apical Domain of Permeabilized MDCK II cells: Requirement for a Rho‐Family GTPase

2001 • 36 citations

Membrane Traffic and Cytokinesis

2000 • 36 citations

A novel structural model for regulation of clathrin function

1997 • 36 citations

Receptor-mediated endocytosis is sensitive to antibodies against the uncoating ATPase (hsc70)

1994 • 34 citations

The Interaction of Calmodulin with Clathrin-coated Vesicles, Triskelions, and Light Chains

1995 • 34 citations

The EH1 Domain of Eps15 Is Structurally Classified as a Member of the S100 Subclass of EF-Hand-Containing Proteins

1999 • 33 citations

Role of clathrin in the regulated secretory pathway of pancreaticβ-cells

2001 • 31 citations

New fashions in vesicle coats

1997 • 30 citations

Alteration of clathrin light chain expression by transfection and gene disruption.

1993 • 30 citations

An Internalization-Competent Influenza Hemagglutinin Mutant Causes the Redistribution of AP-2 to Existing Coated Pits and Is Colocalized with AP-2 in Clathrin Free Clusters

1999 • 29 citations

Tailoring Uniform Coats for Synaptic Vesicles during Endocytosis

1999 • 29 citations

A membrane-associated protein complex with selective binding to the clathrin coat adaptor AP1

1996 • 29 citations

Involvement of clathrin light chains in the pathology of Alzheimer's disease

1994 • 28 citations

Clathrin assembly involves a light chain-binding region.

1987 • 23 citations

Solution Structure of Eps15's Third EH Domain Reveals Coincident Phe−Trp and Asn−Pro−Phe Binding Sites^,

2000 • 22 citations

Molecular interactions between dynamin and G-protein βγ-subunits in neuroendocrine cells

1997 • 21 citations

Molecular Structures of Proteins Involved in Vesicle Coat Formation

2000 • 20 citations

Increased lysosome-related proteins in the skeletal muscles of distal myopathy with rimmed vacuoles

2000 • 19 citations

Involvement of clathrin light chains in the pathology of Pick's disease; impilication for impairment of axonal transport

1994 • 19 citations

β2-Adaptin is constitutively de-phosphorylated by serine/threonine protein phosphatase PP2A and phosphorylated by a staurosporine-sensitive kinase

2000 • 18 citations

Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease

2000 • 16 citations

A Modulatory Role for Clathrin Light Chain Phosphorylation in Golgi Membrane Protein Localization during Vegetative Growth and during the Mating Response ofSaccharomyces cerevisiae

1999 • 14 citations

Involvement of clathrin light chains in the pathology of Alzheimer's disease

1994 • 3 citations

Cloning and Initial Characterization of Human Epsin 3, a Novel Matrix-Induced Keratinocyte Specific Transcript.

2000 • 3 citations

Membrane Traffic and Cytokinesis

2000 • 3 citations