Evidence That Dynamin-2 Functions as a Signal-Transducing Gtpase

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Caspases: Enemies Within

1998 • 6,923 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)

1997 • 1,082 citations

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

1995 • 816 citations

Construction of adenovirus vectors through Cre-lox recombination

1997 • 807 citations

A Human Dynamin-related Protein Controls the Distribution of Mitochondria

1998 • 711 citations

Mutations in human dynamin block an intermediate stage in coated vesicle formation

1993 • 702 citations

Signaling to p53

1998 • 636 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

Analysis of mitochondrial morphology and function with novel fixable fluorescent stains.

1996 • 511 citations

Effects of mutant rat dynamin on endocytosis

1993 • 453 citations

The Human Cytomegalovirus Chemokine Receptor US28 Mediates Vascular Smooth Muscle Cell Migration

1999 • 432 citations

The Dynamin-related GTPase, Dnm1p, Controls Mitochondrial Morphology in Yeast

1998 • 416 citations

Dynamin and its partners: a progress report

1998 • 403 citations

Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring

1999 • 380 citations

YOPRO-1 permits cytofluorometric analysis of programmed cell death (apoptosis) without interfering with cell viability

1995 • 379 citations

Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis

1999 • 364 citations

The dynamin family of mechanoenzymes: pinching in new places

2000 • 345 citations

Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module

1997 • 317 citations

Human cytomegalovirus productively infects primary differentiated macrophages

1991 • 314 citations

The dynamins: Redundant or distinct functions for an expanding family of related GTPases?

1997 • 286 citations

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

1999 • 275 citations

Dynamin Self-assembly Stimulates Its GTPase Activity

1996 • 262 citations

p53 is frequently mutated in Burkitt's lymphoma cell lines.

1991 • 259 citations

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

1999 • 259 citations

Functional diversity in the dynamin family

1999 • 256 citations

Cross‐linking of cell surface immunoglobulins induces epstein‐barr virus in burkitt lymphoma lines

1984 • 253 citations

The p53 pathway and apoptosis

1999 • 222 citations

Garrotes, Springs, Ratchets, and Whips: Putting Dynamin Models to the Test

2000 • 215 citations

Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms

1998 • 208 citations

The Yeast Dynamin-like Protein, Mgm1p, Functions on the Mitochondrial Outer Membrane to Mediate Mitochondrial Inheritance

1999 • 176 citations

Dynamin

1998 • 172 citations

Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase

1999 • 165 citations

A Binding Site for SH3 Domains Targets Dynamin to Coated Pits

1996 • 161 citations

Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)

2000 • 158 citations

Dynamin GTPase, a force‐generating molecular switch

1996 • 150 citations

Loss of function and p53 protein stabilization

1997 • 135 citations

A Model for Dynamin Self-assembly Based on Binding Between Three Different Protein Domains

1999 • 133 citations

A temperature-sensitive mutant of human p53.

1994 • 128 citations

MDM2-arbiter of p53's destruction

1997 • 127 citations

A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans

1997 • 124 citations

Dissociation of Functional Roles of Dynamin in Receptor-mediated Endocytosis and Mitogenic Signal Transduction

1999 • 112 citations

Ubiquitously Expressed Dynamin-II Has a Higher Intrinsic GTPase Activity and a Greater Propensity for Self-assembly Than Neuronal Dynamin-I

1997 • 110 citations

[24] Tightly regulated and inducible expression of dominant interfering dynamin mutant in stably transformed HeLa cells

1995 • 109 citations

Growth kinetics of human cytomegalovirus are altered in monocyte-derived macrophages

1995 • 91 citations

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2

1996 • 89 citations

Dynamin GTPase is stimulated by crosslinking through the C-terminal proline-rich domain.

1995 • 85 citations

Regulation of Dynamin I GTPase Activity by G Protein βγ Subunits and Phosphatidylinositol 4,5-Bisphosphate

1996 • 83 citations

Mechanisms of p53-Mediated Apoptosis

1998 • 75 citations

Dynamin II Is Involved in Endocytosis but Not in the Formation of Transport Vesicles from the trans -Golgi Network1

1999 • 55 citations

Phosphorylation of dynamin by ERK2 inhibits the dynamin‐microtubule interaction

1996 • 46 citations

Mechanisms of p53-induced apoptosis: in search of genes which are regulated during p53-mediated cell death

1998 • 37 citations

Developmental stage- and tissue-specific expression of shibire, a Drosophila gene involved in endocytosis

1992 • 34 citations

Levels of p53 in Epstein–Barr Virus-Infected Cells Determine Cell Fate: Apoptosis, Cell Cycle Arrest at the G1/S Boundary without Apoptosis, Cell Cycle Arrest at the G2/M Boundary without Apoptosis, or Unrestricted Proliferation

1998 • 18 citations

Wild-type p53 induction mediated by replication-deficient adenoviral vectors.

1999 • 11 citations