Cloning of ligand targets: Systematic isolation of SH3 domain-containing proteins

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein modules and signalling networks

1995 • 2,447 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex.

1993 • 510 citations

Two cellular proteins that bind to wild-type but not mutant p53.

1994 • 423 citations

Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2.

1996 • 343 citations

Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries.

1994 • 256 citations

Identification of Four Novel Human Genes Amplified and Overexpressed in Breast Carcinoma and Localized to the q11-q21.3 Region of Chromosome 17

1995 • 248 citations

The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.

1987 • 236 citations

Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk

1994 • 211 citations

The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif

1995 • 175 citations

Drebrin, a development-associated brain protein from rat embryo, causes the dissociation of tropomyosin from actin filaments.

1994 • 173 citations

Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries.

1994 • 166 citations

Autoimmunity in Stiff‐Man Syndrome with breast cancer is targeted to the C‐terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161

1994 • 144 citations

Identification of a Src SH3 domain binding motif by screening a random phage display library.

1994 • 121 citations

Biased combinatorial libraries: novel ligands for the SH3 domain of phosphatidylinositol 3-kinase

1993 • 111 citations

Acquisition of transforming properties by FYN, a normal SRC-related human gene.

1988 • 87 citations

Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking.

1994 • 44 citations

Isolation and characterisation of porcine sorbin

1991 • 27 citations

[36] Use of tyrosine-phosphorylated proteins to screen bacterial expression libraries for SH2 domains

1995 • 6 citations