Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION

1998 • 1,074 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

CLATHRIN-COATED VESICLE FORMATION AND PROTEIN SORTING: An Integrated Process

1997 • 793 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

A presynaptic inositol-5-phosphatase

1996 • 573 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis

1997 • 460 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1997 • 436 citations

Arrestin Interactions with G Protein-coupled Receptors

1995 • 385 citations

Association of the AP-3 Adaptor Complex with Clathrin

1998 • 384 citations

Receptors compete for adaptors found in plasma membrane coated pits.

1988 • 366 citations

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.

1993 • 340 citations

Rhodopsin and phototransduction: a model system for G protein‐linked receptors

1992 • 332 citations

Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin

1993 • 303 citations

Arrestin/Clathrin Interaction

1997 • 290 citations

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

1996 • 290 citations

The pleckstrin homology domain of phospholipase C-.delta.1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes

1995 • 286 citations

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.

1995 • 263 citations

Interaction of Activated EGF Receptors with Coated Pit Adaptins

1993 • 259 citations

Reversible palmitoylation of signaling proteins

1997 • 256 citations

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

1997 • 247 citations

Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.

1994 • 245 citations

Clathrin-mediated Endocytosis of the β-Adrenergic Receptor Is Regulated by Phosphorylation/Dephosphorylation of β-Arrestin1

1997 • 238 citations

X-ray crystal structure of arrestin from bovine rod outer segments

1998 • 236 citations

CLATHRIN AND ASSOCIATED ASSEMBLY AND DISASSEMBLY PROTEINS

1990 • 234 citations

Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes

1997 • 218 citations

Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins

1996 • 217 citations

Arrestin/Clathrin Interaction

1997 • 209 citations

Modulation of the Arrestin-Clathrin Interaction in Cells

1997 • 193 citations

Clathrin assembly proteins: affinity purification and a model for coat assembly.

1987 • 187 citations

A Functional Phosphatidylinositol 3,4,5-Trisphosphate/Phosphoinositide Binding Domain in the Clathrin Adaptor AP-2 α Subunit. IMPLICATIONS FOR THE ENDOCYTIC PATHWAY

1996 • 162 citations

Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).

1989 • 157 citations

In vivo phosphorylation of adaptors regulates their interaction with clathrin.

1996 • 157 citations

Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro.

1996 • 156 citations

Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

1997 • 155 citations

Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15

1997 • 153 citations

Interaction of phosphoinositide cycle intermediates with the plasma membrane-associated clathrin assembly protein AP-2

1991 • 144 citations

Metabolism and biological activities of inositol pentakisphosphate and inositol hexakisphosphate

1995 • 130 citations

Wortmannin-sensitive Trafficking Pathways in Chinese Hamster Ovary Cells

1996 • 129 citations

Regulation of G Protein-Coupled Receptors by Receptor Kinases and Arrestins

1995 • 128 citations

Cell-free expression of visual arrestin. Truncation mutagenesis identifies multiple domains involved in rhodopsin interaction.

1992 • 121 citations

Phosphatidylinositol 4,5-Bisphosphate Binding to the Pleckstrin Homology Domain of Phospholipase C-δ1 Enhances Enzyme Activity

1996 • 115 citations

Regulation of AP-3 Function by Inositides

1997 • 99 citations

Lipid Modifications and Membrane Targeting of G<sub>α</sub>

1998 • 73 citations

Inhibitors of Phosphoinositide 3-Kinase Block Exocytosis but Not Endocytosis of Transferrin Receptors in 3T3-L1 Adipocytes

1995 • 72 citations

Intracellular Mediators: Synthesis of L-.alpha.-Phosphatidyl-D-myo-inositol 3,4,5-Trisphosphate and Glyceryl Ether Analogs

1995 • 68 citations

Binding of inositol phosphates to arrestin

1991 • 67 citations

The α Chain of the AP-2 Adaptor Is a Clathrin Binding Subunit

1995 • 52 citations

Inositol Pentakis- and Hexakisphosphate Metabolism Adds Versatility to the Actions of Inositol Polyphosphates Novel Effects on Ion Channels and Protein Traffic

1996 • 48 citations

G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration

1996 • 44 citations

Purification and Biochemical Characterization of a Mammalian Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase

1995 • 41 citations

Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia.

1992 • 38 citations

Inhibition of Calcium-independent Mannose 6-Phosphate Receptor Incorporation into trans-Golgi Network-derived Clathrin-coated Vesicles by Wortmannin

1997 • 33 citations

Specific Interaction of Golgi Coatomer Protein α-COP with Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 25 citations

Reversibility of coated vesicle dissociation

1982 • 18 citations

Deleted Work

1955 • 0 citations