Protease-activated Receptor-1 Down-regulation

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Primer of biostatistics

1981 • 2,697 citations

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

CLATHRIN-COATED VESICLE FORMATION AND PROTEIN SORTING: An Integrated Process

1997 • 793 citations

Dynamin-mediated Internalization of Caveolae

1998 • 750 citations

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor

1999 • 673 citations

Dynamin at the Neck of Caveolae Mediates Their Budding to Form Transport Vesicles by GTP-driven Fission from the Plasma Membrane of Endothelium

1998 • 657 citations

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

1997 • 625 citations

The β ₂ -adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

1999 • 615 citations

How the protease thrombin talks to cells

1999 • 574 citations

Domains specifying thrombin–receptor interaction

1991 • 553 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

1996 • 450 citations

Dynamin and its partners: a progress report

1998 • 403 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

The Role of Sequestration in G Protein-coupled Receptor Resensitization

1997 • 356 citations

Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization.

1995 • 343 citations

Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene

1994 • 342 citations

Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.

1994 • 329 citations

Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides.

1992 • 308 citations

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

1992 • 306 citations

Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function.

1992 • 291 citations

Internalization and recycling of activated thrombin receptors

1993 • 271 citations

Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module.

1994 • 243 citations

A Central Role for ॆ-Arrestins and Clathrin-coated Vesicle-mediated Endocytosis in ॆ2-Adrenergic Receptor Resensitization

1997 • 234 citations

Distinct Dynamin-dependent and -independent Mechanisms Target Structurally Homologous Dopamine Receptors to Different Endocytic Membranes

1999 • 229 citations

The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity.

1991 • 229 citations

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.

1994 • 228 citations

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.

1994 • 218 citations

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.

1995 • 209 citations

Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms

1998 • 208 citations

Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling

1993 • 205 citations

Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode.

1994 • 188 citations

Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.

1992 • 185 citations

The Cytoplasmic Tails of Protease-activated Receptor-1 and Substance P Receptor Specify Sorting to Lysosomes versusRecycling

1999 • 172 citations

Internalization of the m2 Muscarinic Acetylcholine Receptor

1997 • 170 citations

Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes

1994 • 156 citations

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.

1992 • 146 citations

Role of the Thrombin Receptor's Cytoplasmic Tail in Intracellular Trafficking

1996 • 137 citations

A Dominant-negative Clathrin Mutant Differentially Affects Trafficking of Molecules with Distinct Sorting Motifs in the Class II Major Histocompatibility Complex (MHC) Pathway

1998 • 135 citations

Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting

1998 • 125 citations

Simultaneous visualization of LDL receptor distribution and clathrin lattices on membranes torn from the upper surface of cultured cells.

1991 • 102 citations

Thrombin Receptor Activating Mutations

1996 • 102 citations

Regulation of Thrombin Receptors on Human Umbilical Vein Endothelial Cells

1995 • 100 citations

Predominance of clathrin light chain LCb correlates with the presence of a regulated secretory pathway.

1990 • 80 citations

Mutation of Individual Serine Residues in the C-terminal Tail of the Lutropin/Choriogonadotropin Receptor Reveal Distinct Structural Requirements for Agonist-induced Uncoupling and Agonist-induced Internalization

1998 • 55 citations

Separate Signals for Agonist-independent and Agonist-triggered Trafficking of Protease-activated Receptor 1

1998 • 51 citations