Clathrin: Its Role in Receptor-Mediated Vesicular Transport and Specialized Functions in Neurons

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

YOLK PROTEIN UPTAKE IN THE OOCYTE OF THE MOSQUITO AEDES AEGYPTI. L

1964 • 1,298 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic

1991 • 757 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

1977 • 688 citations

Uncoating ATPase is a member of the 70 kilodalton family of stress proteins

1986 • 607 citations

Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis

1991 • 543 citations

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

1990 • 508 citations

β-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the golgi complex, shows homology to β-adaptin

1991 • 489 citations

Pathways to Regulated Exocytosis in Neurons

1990 • 454 citations

Clathrin-coated vesicles: Isolation, dissociation and factor-dependent reassociation of clathrin baskets

1979 • 450 citations

An enzyme that removes clathrin coats: purification of an uncoating ATPase.

1984 • 449 citations

Substrate specificity determinants for casein kinase II as deduced from studies with synthetic peptides.

1987 • 431 citations

Assembly units of clathrin coats

1981 • 421 citations

Receptors compete for adaptors found in plasma membrane coated pits.

1988 • 366 citations

Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: Effects of brefeldin A and G protein activators

1992 • 358 citations

Structural relationships between clathrin assembly proteins from the Golgi and the plasma membrane.

1988 • 356 citations

Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor.

1989 • 336 citations

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

1987 • 335 citations

Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature-sensitive mutant of Drosophila melanogaster, shibirets1.

1983 • 332 citations

Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling.

1992 • 321 citations

Living with Clathrin: Its Role in Intracellular Membrane Traffic

1988 • 304 citations

The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.

1985 • 301 citations

Protein organization in clathrin trimers

1981 • 298 citations

Cell-free protein sorting to the regulated and constitutive secretory pathways

1990 • 289 citations

Axonal and dendritic endocytic pathways in cultured neurons.

1992 • 271 citations

Enzymatic recycling of clathrin from coated vesicles

1986 • 237 citations

100-kD coated vesicle proteins: molecular heterogeneity and intracellular distribution studied with monoclonal antibodies

1987 • 234 citations

CLATHRIN AND ASSOCIATED ASSEMBLY AND DISASSEMBLY PROTEINS

1990 • 234 citations

Purification and properties of 100-kd proteins from coated vesicles and their reconstitution with clathrin.

1984 • 229 citations

Assembly polypeptides from coated vesicles mediate reassembly of unique clathrin coats.

1983 • 228 citations

Clathrin-coated vesicular transport of secretory proteins during the formation of ACTH-containing secretory granules in AtT20 cells.

1986 • 220 citations

Coated pits act as molecular filters.

1980 • 208 citations

Transferrin receptor and its recycling in HeLa cells.

1982 • 206 citations

A Test of Clathrin Function in Protein Secretion and Cell Growth

1985 • 202 citations

Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins.

1990 • 199 citations

Purification and properties of a new clathrin assembly protein.

1986 • 198 citations

Multiple GTP-binding proteins participate in clathrin-coated vesicle-mediated endocytosis.

1993 • 188 citations

Clathrin assembly proteins: affinity purification and a model for coat assembly.

1987 • 187 citations

Evidence for ADP-ribosylation factor (ARF) as a regulator of in vitro endosome-endosome fusion.

1992 • 185 citations

Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation.

1992 • 184 citations

Axonal Transport: Each Major Rate Component Reflects the Movement of Distinct Macromolecular Complexes

1981 • 179 citations

Location of the 100 kd-50 kd accessory proteins in clathrin coats.

1986 • 165 citations

Deep-etch visualization of proteins involved in clathrin assembly.

1988 • 163 citations

Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis

1990 • 159 citations

Folding and trimerization of clathrin subunits at the triskelion hub

1992 • 157 citations

Stage-specific assays for coated pit formation and coated vesicle budding in vitro.

1991 • 157 citations

Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).

1989 • 157 citations

Assembly of Clathrin-Coated Pits Onto Purified Plasma Membranes

1987 • 153 citations

Auxilin, a newly identified clathrin-associated protein in coated vesicles from bovine brain.

1990 • 152 citations

Selective and immediate effects of clathrin heavy chain mutations on Golgi membrane protein retention in Saccharomyces cerevisiae.

1992 • 147 citations

Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments

1987 • 145 citations

Interaction of phosphoinositide cycle intermediates with the plasma membrane-associated clathrin assembly protein AP-2

1991 • 144 citations

Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus.

1990 • 138 citations

On the structural and functional components of coated vesicles

1978 • 135 citations

Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2.

1989 • 131 citations

Identification of three coated vesicle components as alpha- and beta-tubulin linked to a phosphorylated 50,000-dalton polypeptide.

1983 • 128 citations

Clathrin heavy chain is required for pinocytosis, the presence of large vacuoles, and development in Dictyostelium.

1992 • 126 citations

Deep-etch views of clathrin assemblies

1985 • 126 citations

Three-dimensional structure of clathrin cages in ice.

1986 • 122 citations

Identification of a clathrin binding subunit in the HA2 adaptor protein complex

1989 • 122 citations

Clathrin assembly protein AP180: primary structure, domain organization and identification of a clathrin binding site.

1993 • 118 citations

Clathrin-coated vesicles contain two protein kinase activities. Phosphorylation of clathrin beta-light chain by casein kinase II.

1986 • 113 citations

Location and distribution of the light chains in clathrin trimers.

1983 • 110 citations

Clathrin Light Chains LCA and LCB Are Similar, Polymorphic, and Share Repeated Heptad Motifs

1987 • 109 citations

100-kD proteins of Golgi- and trans-Golgi network-associated coated vesicles have related but distinct membrane binding properties

1992 • 109 citations

Dissociation of clathrin from coated vesicles by the uncoating ATPase.

1990 • 109 citations

Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2

1990 • 108 citations

Requirement for GTP hydrolysis in the formation of secretory vesicles

1990 • 108 citations

The role of coated vesicles in recycling of synaptic vesicle membrane

1989 • 106 citations

Formation of coated vesicles from coated pits in broken A431 cells.

1989 • 105 citations

A role for clathrin light chains in the recognition of clathrin cages by ‘uncoating ATPase’

1984 • 105 citations

The mechanism of receptor‐mediated endocytosis: More questions than answers

1992 • 103 citations

Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits.

1993 • 102 citations

Clathrin heavy chain, light chain interactions.

1983 • 101 citations

Immunofluorescent localization of 100K coated vesicle proteins.

1986 • 99 citations

Secretory granule and synaptic vesicle formation

1991 • 95 citations

Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics

1991 • 94 citations

Conservation and diversity in families of coated vesicle adaptins.

1990 • 94 citations

Clathrin-coated pits contain an integral membrane protein that binds the AP-2 subunit with high affinity.

1990 • 93 citations

Clathrin heavy chain: molecular cloning and complete primary structure.

1987 • 90 citations

Clathrin-associated proteins of bovine brain coated vesicles. An analysis of their number and assembly-promoting activity.

1992 • 89 citations

Biochemical and immunological studies on clathrin light chains and their binding sites on clathrin triskelions.

1983 • 86 citations

Purification and characterization of two distinct complexes of assembly polypeptides from calf brain coated vesicles that differ in their polypeptide composition and kinase activities.

1987 • 85 citations

Cytosol- and clathrin-dependent stimulation of endocytosis in vitro by purified adaptors.

1992 • 84 citations

Biogenesis of secretory granules Implications arising from the immature secretory granule in the regulated pathway of secretion

1991 • 84 citations

Clathrin is axonally transported as part of slow component b: the microfilament complex.

1981 • 81 citations

Predominance of clathrin light chain LCb correlates with the presence of a regulated secretory pathway.

1990 • 80 citations

Yeast clathrin has a distinctive light chain that is important for cell growth.

1990 • 80 citations

Clathrin-coated vesicle assembly polypeptides: physical properties and reconstitution studies with brain membranes.

1988 • 80 citations

Isolation and Preliminary Characterization of Clathrin-Associated Proteins

1982 • 79 citations

Bovine brain clathrin light chains impede heavy chain assembly in vitro

1991 • 77 citations

The appendage domain of the AP-2 subunit is not required for assembly or invagination of clathrin-coated pits.

1993 • 75 citations

Structural domains of clathrin heavy chains.

1984 • 75 citations

The phosphorylation of coated membrane proteins in intact neurons.

1986 • 74 citations

A domain of clathrin that forms coats.

1982 • 74 citations

Endocytosis by African trypanosomes. I. Three-dimensional structure of the endocytic organelles in Trypanosoma brucei and T. congolense.

1989 • 71 citations

Configuration of clathrin trimers: Evidence from electron microscopy

1986 • 71 citations

Clathrin assembly protein AP-3

1991 • 69 citations

Subunit interaction and function of clathrin-coated vesicle adaptors from the Golgi and the plasma membrane.

1991 • 68 citations

Lysosomal enzyme precursors in coated vesicles derived from the exocytic and endocytic pathways.

1987 • 66 citations

Accumulation of coated vesicles bearing mannose 6-phosphate receptors for lysosomal enzymes in the Golgi region of I-cell fibroblasts.

1984 • 65 citations

Release of clathrin from coated vesicles dependent upon a nucleoside triphosphate and a cytosol fraction.

1982 • 64 citations

A neuronal protein (NP185) associated with clathrin-coated vesicles. Characterization of NP185 with monoclonal antibodies.

1988 • 62 citations

Tubulin as a molecular component of coated vesicles.

1983 • 62 citations

Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity

1987 • 61 citations

Trimeric binding of the 70-kD uncoating ATPase to the vertices of clathrin triskelia: a candidate intermediate in the vesicle uncoating reaction.

1989 • 59 citations

Sequence of the clathrin heavy chain from Saccharomyces cerevisiae and requirement of the COOH terminus for clathrin function.

1991 • 58 citations

Biosynthetic protein transport in the secretory pathway

1989 • 58 citations

AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast

1991 • 57 citations

Stable clathrin: uncoating protein (hsc70) complexes in intact neurons and their axonal transport

1991 • 57 citations

Coat proteins isolated from clathrin coated vesicles can assemble into coated pits.

1989 • 56 citations

The medium chains of the mammalian clathrin‐associated proteins have a homolog in yeast

1991 • 56 citations

Limited proteolytic digestion of coated vesicle assembly polypeptides abolishes reassembly activity

1985 • 56 citations

The structure of an endocytosis signal

1992 • 56 citations

Molecular characterization of the AP180 coated vesicle assembly protein

1988 • 55 citations

In vivo phosphorylation of clathrin-coated vesicle proteins from rat reticulocytes.

1988 • 54 citations

Enzymatic dissociation of clathrin cages in a two-stage process.

1985 • 53 citations

Interactions of calmodulin with coated vesicles from brain.

1981 • 53 citations

Axonal transport of a clathrin uncoating atpase (HSC70): A role for hsc70 in the modulation of coated vesicle assembly in vivo

1989 • 52 citations

Self-association of the plasma membrane-associated clathrin assembly protein AP-2

1991 • 52 citations

The gene encoding the small nuclear ribonucleoprotein-associated protein N is expressed at high levels in neurons.

1992 • 51 citations

Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species.

1988 • 50 citations

Two classes of binding sites for uncoating protein in clathrin triskelions.

1985 • 49 citations

Clathrin light chains are calcium-binding proteins.

1987 • 47 citations

Identification of the phosphorylation sites of clathrin light chain LCb.

1988 • 46 citations

Clathrin assembly protein AP-2 induces aggregation of membrane vesicles: a possible role for AP-2 in endosome formation.

1992 • 46 citations

The calcium-binding site of clathrin light chains.

1990 • 44 citations

Molecular Cloning and Complete Amino Acid Sequence of AP50, an Assembly Protein Associated with Clathrin-Coated Vesicles

1988 • 44 citations

Analysis of 100-180-kDa phosphoproteins in clathrin-coated vesicles from bovine brain.

1990 • 42 citations

Clathrin light chain B: gene structure and neuron-specific splicing

1992 • 41 citations

Clathrin domains involved in recognition by assembly protein AP-2.

1991 • 41 citations

Identification of the clathrin-binding domain of assembly protein AP-2

1989 • 40 citations

Coated Vesicles from the Protozoan Parasite Trypanosoma brucei: Purification and Characterization

1989 • 38 citations

Neuron-specific expression of high-molecular-weight clathrin light chain

1990 • 38 citations

Brain clathrin light chain 2 can be phosphorylated by a coated vesicle kinase.

1985 • 38 citations

Polymorphism in clathrin light chains from different tissues

1983 • 38 citations

Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia.

1992 • 38 citations

Site-specific disruption of clathrin assembly produces novel structures.

1986 • 35 citations

Human clathrin heavy chain (CLTC): Partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter

1991 • 34 citations

Identification of a putative yeast homolog of the mammalian beta chains of the clathrin-associated protein complexes.

1990 • 31 citations

Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3.

1990 • 29 citations

Regulated secretion

1990 • 28 citations

Characterization of the Clathrin Heavy Chain fromDictyostelium discoideum

1992 • 28 citations

Involvement of coated vesicles in the initiation of fast axonal transport

1984 • 26 citations

Clathrin light chains and secretory vesicle binding proteins are distinct

1984 • 25 citations

Brain Clathrin: Studies of Its Ultrastructural Assemblies

1982 • 24 citations

Clathrin assembly involves a light chain-binding region.

1987 • 23 citations

Phosphorylation of Tubulin by Casein Kinase II Regulates Its Binding to a Neuronal Protein (NP185) Associated with Brain Coated Vesicles

1989 • 22 citations

Targeting and fusion in vesicular transport

1992 • 21 citations

Axonal transport of clathrin-associated proteins

1987 • 20 citations

Genetic analysis of clathrin function in yeast

1990 • 18 citations

Comparison of the primary structures of clathrin light chains from bovine brain and adrenal gland by peptide mapping.

1984 • 17 citations

The intracellular movement and cycling of ricin.

1990 • 14 citations

Multiple Endocytic Pathways

1992 • 14 citations

The occurrence of disulphide bonds in purified clathrin light chains

1989 • 13 citations

Biochemical characterization of algal coated vesicles

1990 • 5 citations