BIN1 is a novel MYC–interacting protein with features of a tumour suppressor

Antibodies, a laboratory manual

1989 • 12,929 citations

Genomic sequencing.

1984 • 8,343 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Antibodies: A laboratory manual

1989 • 4,532 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

PRINCIPLES OF INTERNAL MEDICINE

1955 • 1,365 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation

1996 • 787 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

1991 • 576 citations

An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation.

1988 • 476 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Definition of regions in human c-myc that are involved in transformation and nuclear localization.

1987 • 457 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

1990 • 413 citations

Dominant negative MYC blocks transformation by ABL oncogenes

1992 • 410 citations

A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals.

1996 • 408 citations

Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping.

1996 • 398 citations

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

1983 • 378 citations

The role of c-myc in cell growth

1993 • 365 citations

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

1994 • 313 citations

Autoantibodies to a 128-kd Synaptic Protein in Three Women with the Stiff-Man Syndrome and Breast Cancer

1993 • 310 citations

Point mutations in the c–Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas

1993 • 283 citations

c-Myc and apoptosis

1995 • 251 citations

Binding and Suppression of the Myc Transcriptional Activation Domain by p107

1994 • 242 citations

Ornithine Decarboxylase Is a Mediator of c-Myc-Induced Apoptosis

1994 • 238 citations

Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo.

1994 • 224 citations

Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis.

1994 • 214 citations

c-myc amplification is a better prognostic factor than HER2/neu amplification in primary breast cancer.

1992 • 212 citations

Amphiphysin, a novel protein associated with synaptic vesicles.

1992 • 192 citations

Alteration of a yeast SH3 protein leads to conditional viability with defects in cytoskeletal and budding patterns.

1993 • 172 citations

The ras-Related Gene rhoB Is an Immediate-Early Gene Inducible by v-Fps, Epidermal Growth Factor, and Platelet-Derived Growth Factor in Rat Fibroblasts

1991 • 162 citations

Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62.

1993 • 160 citations

c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms.

1995 • 145 citations

A Link between Increased Transforming Activity of Lymphoma-Derived MYC Mutant Alleles, Their Defective Regulation by p107, and Altered Phosphorylation of the c-Myc Transactivation Domain

1995 • 142 citations

Effects of c-myc Expression on Cell Cycle Progression

1994 • 141 citations

Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation.

1994 • 139 citations

An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc.

1994 • 127 citations

The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts.

1991 • 115 citations

Posttranscriptional regulation of cellular gene expression by the c-myc oncogene.

1989 • 108 citations

The functions of Myc proteins

1992 • 103 citations

Clustered mutations in the second exon of the MYC gene in sporadic Burkitt's lymphoma.

1993 • 102 citations

Chromosomal aberrations observed in 52 mouse myeloid leukemias.

1983 • 99 citations

Effects of c-myc expression on cell cycle progression.

1994 • 93 citations

Mbh 1: a novel gelsolin/severin-related protein which binds actin in vitro and exhibits nuclear localization in vivo.

1991 • 87 citations

Tumorigenicity of fibroblast lines expressing the adenovirus E1a, cellular p53, or normal c-myc genes.

1986 • 85 citations

Relationship of c-myc Amplification to Progression of Breast Cancer From In Situ to Invasive Tumor and Lymph Node Metastasis

1993 • 84 citations

c-Myc cooperates with activated Ras to induce the cdc2 promoter.

1994 • 78 citations

Amplification of c-myc but not of c-erbB-2 is associated with high proliferative capacity in breast cancer.

1993 • 73 citations

Cell cycle regulation of the c-Myc transcriptional activation domain.

1993 • 71 citations

Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells.

1991 • 61 citations

Biphasic effect of Max on Myc cotransformation activity and dependence on amino- and carboxy-terminal Max functions.

1992 • 59 citations

Principles of Internal Medicine

1967 • 58 citations

A Saccharomyces cerevisiae protein-serine kinase related to mammalian glycogen synthase kinase-3 and the Drosophila melanogaster gene shaggy product

1993 • 32 citations

The Bin1 Gene Localizes to Human Chromosome 2q14 by PCR Analysis of Somatic Cell Hybrids and Fluorescencein SituHybridization

1996 • 27 citations

C‐myc oncogene expression: A marker for females at risk of breast carcinoma

1993 • 26 citations

Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic Stiff—Man syndrome, and mapping of its gene (AMPH) to chromosome 7p13–p14

1995 • 26 citations

Synthesis of human gamma-glutamyl transpeptidase (GGT) during the fetal development of liver

1990 • 11 citations