Saturation of the Endocytic Pathway for the Transferrin Receptor Does Not Affect the Endocytosis of the Epidermal Growth Factor Receptor

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Histologic fixatives suitable for diagnostic light and electron microscopy.

1976 • 1,272 citations

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

1995 • 955 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

1990 • 508 citations

The J. D. mutation in familial hypercholesterolemia: Amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors

1986 • 372 citations

Receptors compete for adaptors found in plasma membrane coated pits.

1988 • 366 citations

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

1987 • 355 citations

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1984 • 337 citations

Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor.

1989 • 336 citations

Interaction of Activated EGF Receptors with Coated Pit Adaptins

1993 • 259 citations

The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation

1991 • 246 citations

A single amino acid change in the cytoplasmic domain allows the influenza virus hemagglutinin to be endocytosed through coated pits

1988 • 245 citations

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.

1988 • 236 citations

Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins.

1990 • 199 citations

Maturation of the yeast plasma membrane [H+]ATPase involves phosphorylation during intracellular transport.

1991 • 199 citations

Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site

1987 • 192 citations

Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail.

1991 • 188 citations

Epidermal Growth Factor Receptor Interaction with Clathrin Adaptors Is Mediated by the Tyr974-containing Internalization Motif

1996 • 167 citations

The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a β turn

1991 • 165 citations

Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.

1993 • 155 citations

Assembly of Clathrin-Coated Pits Onto Purified Plasma Membranes

1987 • 153 citations

Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker

1988 • 146 citations

A role for the cytoplasmic domain in transferrin receptor sorting and coated pit formation during endocytosis

1988 • 140 citations

Human transferrin receptor internalization is partially dependent upon an aromatic amino acid on the cytoplasmic domain.

1990 • 130 citations

The basolateral targeting signal in the cytoplasmic domain of glycoprotein G from vesicular stomatitis virus resembles a variety of intracellular targeting motifs related by primary sequence but having diverse targeting activities.

1994 • 127 citations

Transferrin receptors promote the formation of clathrin lattices

1991 • 122 citations

YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis.

1993 • 121 citations

Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain.

1990 • 121 citations

Stoichiometric Interaction of the Epidermal Growth Factor Receptor with the Clathrin-associated Protein Complex AP-2

1995 • 119 citations

In vitro binding of plasma membrane-coated vesicle adaptors to the cytoplasmic domain of lysosomal acid phosphatase

1993 • 114 citations

Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment.

1995 • 111 citations

The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.

1992 • 105 citations

Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits.

1993 • 102 citations

Association of Epidermal Growth Factor Receptors with Coated Pit Adaptins via a Tyrosine Phosphorylation-regulated Mechanism

1995 • 98 citations

Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor.

1991 • 93 citations

Clathrin-coated pits contain an integral membrane protein that binds the AP-2 subunit with high affinity.

1990 • 93 citations

Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins.

1995 • 89 citations

Co-migration and internalization of transferrin and its receptor on K562 cells.

1983 • 82 citations

Recruitment of epidermal growth factor and transferrin receptors into coated pits in vitro: differing biochemical requirements.

1993 • 76 citations

Assembly of the mannose-6-phosphate receptor into reconstituted clathrin coats.

1985 • 71 citations

A mutated transferrin receptor lacking asparagine-linked glycosylation sites shows reduced functionality and an association with binding immunoglobulin protein.

1991 • 66 citations

Endocytosis of activated receptors and clathrin-coated pit formation: deciphering the chicken or egg relationship.

1996 • 65 citations

Endocytosis of the ASGP receptor H1 is reduced by mutation of tyrosine-5 but still occurs via coated pits.

1991 • 62 citations

Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry.

1985 • 57 citations

Chapter 20 Preservation of Biological Specimens for Observation in a Confocal Fluorescence Microscope and Operational Principles of Confocal Fluorescence Microscopy

1989 • 55 citations

A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis

1990 • 43 citations

The tyrosine-containing internalization motif in the cytoplasmic domain of TGN38/41 lies within a nascent helix.

1994 • 35 citations