The role of endosomes and lysosomes in MHC class II functioning

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

ENDOCYTOSIS AND MOLECULAR SORTING

1996 • 1,537 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

1996 • 904 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

Intracellular receptor sorting during endocytosis: Comparative immunoelectron microscopy of multiple receptors in rat liver

1984 • 359 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

Late endosomes derive from early endosomes by maturation

1991 • 311 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the Endocytic Pathway

1995 • 280 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Antigen presentation mediated by recycling of surface HLA-DR molecules

1995 • 271 citations

The Autophagic and Endocytic Pathways Converge at the Nascent Autophagic Vacuoles

1997 • 265 citations

Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells

1991 • 250 citations

Reduction of disulfide bonds within lysosomes is a key step in antigen processing.

1991 • 245 citations

Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments

1994 • 244 citations

Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments

1997 • 233 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization.

1993 • 221 citations

Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface.

1996 • 210 citations

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1995 • 198 citations

Processed antigen binds to newly synthesized mhc class II molecules in antigen-specific B lymphocytes

1991 • 188 citations

How MHC class II molecules reach the endocytic pathway.

1995 • 173 citations

Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells.

1992 • 167 citations

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1993 • 146 citations

Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain.

1991 • 145 citations

Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes.

1995 • 130 citations

The biogenesis of the MHC class II compartment in human I-cell disease B lymphoblasts.

1996 • 72 citations

Characterization of MHC Class II Compartments by Immunoelectron Microscopy

1996 • 55 citations

Characterization of transport of newly assembled, T cell-stimulatory MHC class II-peptide complexes from MHC class II compartments to the cell surface.

1997 • 53 citations

Antigen processing and intracellular traffic of antigens and MHC molecules

1993 • 41 citations

Decreased Endosomal Delivery of Major Histocompatibility Complex Class II-invariant Chain Complexes in Dynamin-deficient Cells

1997 • 38 citations

Antigen entry into early endosomes is insufficient for MHC class II processing.

1993 • 36 citations

Different endocytic compartments are involved in the tight association of class ii molecules with processed hen egg lysozyme and ribonuclease a in b cells

1995 • 32 citations

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