Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Opening of Compacted Chromatin by Early Developmental Transcription Factors HNF3 (FoxA) and GATA-4

2002 • 1,136 citations

Molecular Mechanisms RegulatinG Th1 Immune Responses

2003 • 1,005 citations

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

2002 • 985 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

Genomic Regulatory Systems: Development and Evolution

2005 • 710 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet

2002 • 633 citations

REGULATION OF TH2 DIFFERENTIATION ANDIl4LOCUS ACCESSIBILITY

2006 • 625 citations

T Helper Cell Fate Specified by Kinase-Mediated Interaction of T-bet with GATA-3

2005 • 505 citations

The runx genes: gain or loss of function in cancer

2005 • 449 citations

Regulatory Controls for Osteoblast Growth and Differentiation: Role of Runx/Cbfa/AML Factors

2004 • 438 citations

An epigenetic view of helper T cell differentiation

2003 • 429 citations

The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

2002 • 424 citations

Long-range intrachromosomal interactions in the T helper type 2 cytokine locus

2004 • 421 citations

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

2003 • 380 citations

T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription

2006 • 326 citations

T Helper Cell Differentiation: Regulation by cis Elements and Epigenetics

2006 • 315 citations

Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction

2002 • 304 citations

Runx3 regulates mouse TGF-β-mediated dendritic cell function and its absence results in airway inflammation

2004 • 281 citations

Structure and regulated expression of mammalian RUNX genes

2004 • 276 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

Core-binding factors in hematopoiesis and immune function

2004 • 236 citations

Assembling a Gene Regulatory Network for Specification of the B Cell Fate

2004 • 233 citations

Regulation of the Th2 Cytokine Locus by a Locus Control Region

2003 • 222 citations

GATA-3-dependent enhancer activity in IL-4 gene regulation.

1998 • 205 citations

Deletion of a coordinate regulator of type 2 cytokine expression in mice

2001 • 196 citations

Th2-Specific Chromatin Remodeling and Enhancer Activity in the Th2 Cytokine Locus Control Region

2004 • 188 citations

Role of RUNX family members in transcriptional repression and gene silencing

2004 • 173 citations

Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia

2004 • 166 citations

Dual Functions of Runx Proteins for Reactivating CD8 and Silencing CD4 at the Commitment Process into CD8 Thymocytes

2005 • 160 citations

Cutting Edge: GATA-3-Dependent Enhancer Activity in IL-4 Gene Regulation

1998 • 158 citations

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1998 • 139 citations

A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison

2004 • 137 citations

Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells

2004 • 134 citations

Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease

2005 • 127 citations

The Runx1 Transcription Factor Inhibits the Differentiation of Naive CD4+ T Cells into the Th2 Lineage by Repressing GATA3 Expression

2003 • 124 citations

The Interleukin-4 Enhancer CNS-2 Is Regulated by Notch Signals and Controls Initial Expression in NKT Cells and Memory-Type CD4 T Cells

2006 • 121 citations

Mammalian runt‐domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia

1999 • 118 citations

A 3′ Enhancer in the IL-4 Gene Regulates Cytokine Production by Th2 Cells and Mast Cells

2002 • 117 citations

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

2004 • 114 citations

Runx3 Regulates Integrin αE/CD103 and CD4 Expression during Development of CD4−/CD8+ T Cells

2005 • 112 citations

Epigenetic control in the immune response

2005 • 103 citations

Issues in T‐helper 1 development – resolved and unresolved

2004 • 99 citations

Chromatin landscape dynamics of theIl4–Il13locus during T helper 1 and 2 development

2004 • 96 citations

Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: A target for STAT6 but not GATA3

2004 • 94 citations

Mammalian runt-domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia

1999 • 90 citations

Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA

2004 • 76 citations

Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3

2006 • 63 citations

Epigenetic gene silencing by Runx proteins

2004 • 63 citations

Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN- promoter

2003 • 62 citations

Regulation of AML2/CBFA3 in Hematopoietic Cells through the Retinoic Acid Receptor α-Dependent Signaling Pathway

1999 • 57 citations

Th2 Cells: Orchestrating Barrier Immunity

2004 • 54 citations

Up-Regulation of Hlx in Immature Th Cells Induces IFN-γ Expression

2004 • 51 citations

Cutting Edge: A Critical Role for Gene Silencing in Preventing Excessive Type 1 Immunity

2005 • 38 citations

Basal Chromatin Modification at the IL-4 Gene in Helper T Cells

2003 • 36 citations

Expression of AML1-d, a short human AML1 isoform, in embryonic stem cells suppresses in vivo tumor growth and differentiation

1998 • 29 citations

“Runx”ing towards Sensory Differentiation

2006 • 25 citations

Homologs of RUNX and CBFβ/PEBP2β in C. elegans

2004 • 22 citations