Role of RUNX family members in transcriptional repression and gene silencing

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

2001 • 2,768 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases

2000 • 2,709 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

2001 • 1,685 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer

2002 • 1,019 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia

1993 • 760 citations

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

1995 • 738 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 582 citations

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

1995 • 546 citations

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1998 • 525 citations

Molecular Cloning and Characterization of PEBP2β, the Heterodimeric Partner of a Novel Drosophila runt-Related DNA Binding Protein PEBP2α

1993 • 504 citations

Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO

1998 • 500 citations

Interaction and Functional Cooperation of PEBP2/CBF with Smads

1999 • 449 citations

ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors

1998 • 442 citations

Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor

1993 • 425 citations

The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

2002 • 424 citations

CCAAT Enhancer-Binding Protein (C/EBP) and AML1 (CBFα2) Synergistically Activate the Macrophage Colony-Stimulating Factor Receptor Promoter

1996 • 399 citations

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

2003 • 380 citations

ETO, a Target of t(8;21) in Acute Leukemia, Makes Distinct Contacts with Multiple Histone Deacetylases and Binds mSin3A through Its Oligomerization Domain

2001 • 345 citations

Runx2 (Cbfa1, AML-3) Interacts with Histone Deacetylase 6 and Represses the p21^CIP1/WAF1 Promoter

2002 • 314 citations

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

1998 • 308 citations

The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation

1998 • 280 citations

The t(8;21) fusion protein, AML1–ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia

2002 • 262 citations

Groucho-Dependent and -Independent Repression Activities of Runt Domain Proteins

1997 • 253 citations

A Mechanism of Repression by Acute Myeloid Leukemia-1, the Target of Multiple Chromosomal Translocations in Acute Leukemia

2000 • 246 citations

Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBFα/AML/PEBP2α) dependent activation of tissue-specific gene transcription

2000 • 236 citations

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

1999 • 225 citations

Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1

1998 • 218 citations

Both TEL and AML-1 Contribute Repression Domains to the t(12;21) Fusion Protein

1999 • 163 citations

The inv(16) Fusion Protein Associates with Corepressors via a Smooth Muscle Myosin Heavy-Chain Domain

2003 • 160 citations

MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2

2002 • 152 citations

Smad and AML Proteins Synergistically Confer Transforming Growth Factor β1 Responsiveness to Human Germ-line IgA Genes

2000 • 148 citations

Auto-Inhibition and Partner Proteins, Core-Binding Factor β (CBFβ) and Ets-1, Modulate DNA Binding by CBFα2 (AML1)

2000 • 146 citations

Transcriptional Regulation of the Transforming Growth Factor-β-inducible Mouse Germ Line Ig α Constant Region Gene by Functional Cooperation of Smad, CREB, and AML Family Members

2000 • 132 citations

Functional and Physical Interactions between AML1 Proteins and an ETS Protein, MEF: Implications for the Pathogenesis of t(8;21)-Positive Leukemias

1999 • 129 citations

TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced Transactivation

1998 • 123 citations

TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3

2001 • 98 citations

Inhibition of the Transforming Growth Factor β1 Signaling Pathway by the AML1/ETO Leukemia-associated Fusion Protein

2000 • 93 citations

Mechanisms of transcriptional regulation by Runt domain proteins

2000 • 81 citations

Runt and Lozenge function in Drosophila development

2000 • 75 citations

Distinct in vivo requirements for establishment versus maintenance of transcriptional repression

2002 • 54 citations

Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia–associated TEL-AML1 oncoprotein

2000 • 26 citations