Interaction between the Amino-terminal SH3 Domain of CRK and Its Natural Target Proteins

Antibodies, a laboratory manual

1989 • 12,929 citations

Protein modules and signalling networks

1995 • 2,447 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system

1991 • 1,071 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.

1994 • 391 citations

c-Abl kinase regulates the protein binding activity of c-Crk.

1994 • 362 citations

Identification of Rap1 as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G

1995 • 359 citations

Signalling through SH2 and SH3 domains

1993 • 355 citations

DOCK180, a Major CRK-Binding Protein, Alters Cell Morphology upon Translocation to the Cell Membrane

1996 • 339 citations

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.

1994 • 313 citations

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

1994 • 310 citations

Two species of human CRK cDNA encode proteins with distinct biological activities.

1992 • 269 citations

eps15, a novel tyrosine kinase substrate, exhibits transforming activity.

1993 • 265 citations

Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk

1995 • 243 citations

Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk

1994 • 211 citations

Crystal Structure of the Mammalian Grb2 Adaptor

1995 • 202 citations

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

1994 • 182 citations

SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.

1993 • 177 citations

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

1992 • 168 citations

Structure and function of the SH3 domain

1994 • 168 citations

Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries.

1994 • 166 citations

v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1995 • 151 citations

The product of the cellular crk gene consists primarily of SH2 and SH3 regions.

1992 • 147 citations

Interactions between collagen-binding stress protein HSP47 and collagen. Analysis of kinetic parameters by surface plasmon resonance biosensor.

1994 • 142 citations

Characterization of the Interaction of Natural Proline-Rich Peptides with Five Different SH3 Domains

1994 • 131 citations

Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.

1994 • 126 citations

Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.

1994 • 125 citations

Identification of a Src SH3 domain binding motif by screening a random phage display library.

1994 • 121 citations

Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro.

1992 • 120 citations

The Product of the cbl Oncogene Forms Stable Complexes In Vivo with Endogenous Crk in a Tyrosine Phosphorylation-Dependent Manner

1996 • 117 citations

Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells.

1993 • 100 citations

Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways.

1995 • 100 citations

Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins.

1995 • 100 citations

Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos

1994 • 97 citations

Structures of SH2 and SH3 domains

1993 • 92 citations

The SH3 Domain of Crk Binds Specifically to a Conserved Proline-rich Motif in Eps15 and Eps15R

1995 • 89 citations

Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.

1994 • 79 citations

Solution structure and ligand–binding site of the carboxy–terminal SH3 domain of GRB2

1994 • 66 citations

Quantitative analysis of Grb2-Sos1 interaction: the N-terminal SH3 domain of Grb2 mediates affinity.

1995 • 51 citations

The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat 3Y1 cells.

1994 • 40 citations

Backwards and forwards binding

1994 • 33 citations

Signalling an interest

1994 • 12 citations