The fibronectin-binding integrins α5β1 and αvβ3 differentially modulate RhoA–GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins

2002 • 8,127 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Taking Cell-Matrix Adhesions to the Third Dimension

2001 • 2,940 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 • 1,279 citations

Function and interactions of integrins

2001 • 1,018 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Consequences of lack of beta 1 integrin gene expression in mice.

1995 • 724 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.

1994 • 617 citations

Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly

1998 • 589 citations

Dynamics and segregation of cell–matrix adhesions in cultured fibroblasts

2000 • 574 citations

Changes in integrin receptors on oncogenically transformed cells

1989 • 548 citations

Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

2000 • 502 citations

The Evolution of Cell Adhesion

2000 • 478 citations

Integrin Dynamics and Matrix Assembly

2000 • 459 citations

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

2000 • 454 citations

Fibronectin, integrins, and growth control

2001 • 452 citations

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

2000 • 429 citations

Relationships between fibronectin (LETS protein) and actin

1978 • 428 citations

Rho-family GTPases in cadherin-mediated cell — cell adhesion

2001 • 424 citations

Cadherin Engagement Regulates Rho family GTPases

2001 • 421 citations

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1991 • 367 citations

Syndecan-4 signals cooperatively with integrins in a Rhodependent manner in the assembly of focal adhesions and actin stress fibers

1999 • 360 citations

Integrin signaling revisited

2001 • 355 citations

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix

1995 • 349 citations

Cadherins and tissue formation: integrating adhesion and signaling

1999 • 318 citations

Signaling networks linking integrins and Rho family GTPases

2000 • 310 citations

Fibronectin fibrillogenesis: a paradigm for extracellular matrix assembly

1999 • 303 citations

Beta 1 integrin-dependent and -independent polymerization of fibronectin.

1996 • 292 citations

Complexity and specificity of integrin signalling

2000 • 244 citations

Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin–green fluorescent protein

1999 • 222 citations

Fibronectin's III-1 module contains a conformation-dependent binding site for the amino-terminal region of fibronectin.

1994 • 204 citations

Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins.

1994 • 198 citations

Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction.

1997 • 197 citations

The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin

1993 • 188 citations

Coexisting conformations of fibronectin in cell culture imaged using fluorescence resonance energy transfer

2001 • 188 citations

Vinexin: A Novel Vinculin-binding Protein with Multiple SH3 Domains Enhances Actin Cytoskeletal Organization

1999 • 183 citations

Requirement for the Synergy Site for Cell Adhesion to Fibronectin Depends on the Activation State of Integrin α5β1

1995 • 164 citations

The alpha 5 beta 1 integrin fibronectin receptor, but not the alpha 5 cytoplasmic domain, functions in an early and essential step in fibronectin matrix assembly.

1993 • 160 citations

Cross Talk between Adhesion Molecules: Control of N-cadherin Activity by Intracellular Signals Elicited by β1 and β3 Integrins in Migrating Neural Crest Cells

1997 • 155 citations

Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin

1996 • 152 citations

Induction of Cell Scattering by Expression of β1 Integrins in β1-Deficient Epithelial Cells Requires Activation of Members of the Rho Family of Gtpases and Downregulation of Cadherin and Catenin Function

1999 • 150 citations

Arg-Gly-Asp recognition by a cell adhesion receptor requires its 130-kDa alpha subunit.

1987 • 137 citations

Developmental changes in expression of contractile and cytoskeletal proteins in human aortic smooth muscle.

1990 • 136 citations

Syndecans: transmembrane modulators of adhesion and matrix assembly

2001 • 131 citations

Requirement for Rho in Integrin Signalling

1997 • 127 citations

Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins.

1996 • 127 citations

TRANSMEMBRANE LINKAGE OF FIBRONECTIN TO INTRACELLULAR ACTIN‐CONTAINING FILAMENTS IN CULTURED HUMAN FIBROBLASTS*

1978 • 120 citations

Dual Stimulation of Ras/Mitogen-Activated Protein Kinase and Rhoa by Cell Adhesion to Fibronectin Supports Growth Factor–Stimulated Cell Cycle Progression

2000 • 116 citations

A novel fibronectin binding site required for fibronectin fibril growth during matrix assembly

2001 • 113 citations

Modulation of β1A Integrin Functions by Tyrosine Residues in the β1 Cytoplasmic Domain

1998 • 109 citations

Identification of a New Biological Function for the Integrin α_vβ₃: Initiation of Fibronectin Matrix Assembly

1996 • 106 citations

Cytoskeletal changes induced by GRAF, the <u>G</u>TPase <u>r</u>egulator <u>a</u>ssociated with <u>f</u>ocal adhesion kinase, are mediated by Rho

1999 • 100 citations

Differential regulation of Rho GTPases by β1 and β3 integrins: the role of an extracellular domain of integrin in intracellular signaling

2002 • 97 citations

Localization of fibronectin matrix assembly sites on fibroblasts and endothelial cells

1997 • 94 citations

ADAM13 Disintegrin and Cysteine-rich Domains Bind to the Second Heparin-binding Domain of Fibronectin

2002 • 89 citations

Characterization of Graf, the GTPase-activating Protein for Rho Associated with Focal Adhesion Kinase

1998 • 82 citations

Y-27632, an Inhibitor of Rho-Associated Kinases, Prevents Tyrosine Phosphorylation of Focal Adhesion Kinase and Paxillin Induced by Bombesin: Dissociation from Tyrosine Phosphorylation of p130cas

2001 • 72 citations

Functional interaction between E-cadherin and αv-containing integrins in carcinoma cells

2000 • 64 citations

The integrin β tail is required and sufficient to regulate adhesion signaling to Rac1

2002 • 64 citations

Cross Talk between β₁and α_VIntegrins: β₁Affects β₃mRNA Stability

2001 • 59 citations

Organization of the Provisional Fibronectin Matrix: Control by Products of Blood Coagulation

1995 • 59 citations

Restoration of β1A Integrins is Required for Lysophosphatidic Acid-induced Migration of β1-null Mouse Fibroblastic Cells

1998 • 52 citations

Differential utilization of VLA-4 (α4β1) and -5 (α5β1) integrins during the development of mouse bone marrow-derived mast cells

1996 • 36 citations

Integrin β3 cDNA Transfection into a Highly Metastatic αvβ3-Negative Human Melanoma Cell Line Inhibits Invasion and Experimental Metastasis

1996 • 33 citations

Functional β1-Integrins Release the Suppression of Fibronectin Matrix Assembly by Vitronectin

1999 • 21 citations