Cyclic AMP and Protein Kinase A Stimulate Cdc42: Role of A₂Adenosine Receptors in Human Mast Cells

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Comparative pharmacology of human adenosine receptor subtypes – characterization of stably transfected receptors in CHO cells

1997 • 720 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity

1999 • 546 citations

Structure and Function of Cyclic Nucleotide-Dependent Protein Kinases

1994 • 442 citations

A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho

1999 • 386 citations

Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma.

1995 • 364 citations

Rapid protein kinase assay using phosphocellulose-paper absorption

1975 • 363 citations

cAMP-induced Morphological Changes Are Counteracted by the Activated RhoA Small GTPase and the Rho Kinase ROKα

1998 • 267 citations

Elevation of Intracellular cAMP Inhibits RhoA Activation and Integrin-dependent Leukocyte Adhesion Induced by Chemoattractants

1997 • 205 citations

Stimulation of the Mitogen-activated Protein Kinase via the A2A-Adenosine Receptor in Primary Human Endothelial Cells

1997 • 187 citations

Adenosine A2B receptors: a novel therapeutic target in asthma?

1998 • 178 citations

Adenosine Receptor Activation Induces Vascular Endothelial Growth Factor in Human Retinal Endothelial Cells

1999 • 163 citations

A2B Adenosine and P2Y2 Receptors Stimulate Mitogen-activated Protein Kinase in Human Embryonic Kidney-293 Cells

1999 • 160 citations

Purines and their roles in apoptosis

1997 • 144 citations

Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells.

1999 • 131 citations

Nerve growth factor (NGF) expression in rat microglia is induced by adenosine A2a-receptors

1997 • 114 citations

Cyclic nucleotide gated channels as regulators of CNS development and plasticity

1997 • 110 citations

Pharmacological characterization of adenosine A2B receptors

1998 • 90 citations

Apoptosis by 2-chloro-2′-deoxy-adenosine and 2-chloro-adenosine in human peripheral blood mononuclear cells

1998 • 72 citations

Recent developments in selective agonists and antagonists acting at purine and pyrimidine receptors

1996 • 66 citations

Selective control of membrane ruffling and actin plaque assembly by the Rho GTPases Rac1 and CDC42 in FcεRI-activated rat basophilic leukemia (RBL-2H3) cells

1997 • 63 citations

A nonradioactive biochemical characterization of membrane proteins using enhanced chemiluminescence

1992 • 60 citations

Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells.

1994 • 60 citations

P1 and P2 receptors in cell growth and differentiation

1996 • 58 citations

Characterization of adenosine receptors in human erythroleukemia cells and platelets: further evidence for heterogeneity of adenosine A2 receptor subtypes.

1993 • 55 citations

Potential drug targets: small GTPases that regulate leukocyte function

1999 • 36 citations

Adenosine and asthma

1986 • 29 citations

Purinoceptors in the regulation of cell growth and differentiation

1996 • 19 citations

Stimulation of the A2A adenosine receptor increases expression of the tyrosine hydroxylase gene

1997 • 9 citations