Patterns of Gene Expression Reveal a Temporally Orchestrated Wound Healing Response in the Injured Spinal Cord

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

In silico prediction of protein-protein interactions in human macrophages

2014 • 11,120 citations

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

Cutaneous Wound Healing

1999 • 5,878 citations

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

Wound Healing--Aiming for Perfect Skin Regeneration

1997 • 4,630 citations

Regulation of Wound Healing by Growth Factors and Cytokines

2003 • 3,383 citations

Regeneration beyond the glial scar

2004 • 2,896 citations

Liver Regeneration

1997 • 2,731 citations

Chondroitinase ABC promotes functional recovery after spinal cord injury

2002 • 2,236 citations

The many faces of macrophage activation

2003 • 1,860 citations

The glial scar and central nervous system repair

1999 • 1,757 citations

Spinal-cord injury

2002 • 1,607 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 1,508 citations

Angiogenesis in Wound Healing

2000 • 1,288 citations

Extracellular matrix remodelling: the role of matrix metalloproteinases

2003 • 1,061 citations

Secretory Granule Exocytosis

2003 • 914 citations

Cellular inflammatory response after spinal cord injury in sprague-dawley and lewis rats

1997 • 892 citations

GENERAL PRINCIPLES OF WOUND HEALING

1997 • 793 citations

The extracellular matrix as a scaffold for tissue reconstruction

2002 • 793 citations

Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development

2003 • 707 citations

Transforming growth factor βs and wound healing

1997 • 623 citations

The Pathology of Human Spinal Cord Injury: Defining the Problems

2004 • 616 citations

Post-traumatic inflammation following spinal cord injury

2003 • 591 citations

Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma.

1999 • 561 citations

Peroxisome Proliferator-activated Receptor γ Ligands Are Potent Inhibitors of Angiogenesis in Vitro and in Vivo

1999 • 527 citations

Actin cables and epidermal movement in embryonic wound healing

1992 • 492 citations

Acute Inflammatory Response in Spinal Cord Following Impact Injury

1998 • 486 citations

Matrix Metalloproteinases Limit Functional Recovery after Spinal Cord Injury by Modulation of Early Vascular Events

2002 • 477 citations

The Chondroitin Sulfate Proteoglycans Neurocan and Phosphacan Are Expressed by Reactive Astrocytes in the Chronic CNS Glial Scar

1999 • 473 citations

Progranulin is a mediator of the wound response

2003 • 459 citations

Cellular and Molecular Mechanisms of Glial Scarring and Progressive Cavitation:In VivoandIn VitroAnalysis of Inflammation-Induced Secondary Injury after CNS Trauma

1999 • 455 citations

Chapter 22 Chondroitin sulphate proteoglycans in the CNS injury response

2002 • 415 citations

Essential Role of Growth Hormone in Ischemia-Induced Retinal Neovascularization

1997 • 394 citations

Vascular Events After Spinal Cord Injury: Contribution to Secondary Pathogenesis

2000 • 379 citations

Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin‐C during acute to chronic maturation of spinal cord scar tissue

2002 • 379 citations

The many faces of tumor necrosis factor in stroke

2002 • 369 citations

Differential Injury Responses in Oral Mucosal and Cutaneous Wounds

2003 • 368 citations

Role of neutrophils in spinal cord injury in the rat

1997 • 355 citations

Rats and mice exhibit distinct inflammatory reactions after spinal cord injury

2003 • 354 citations

RECENT ADVANCES IN PATHOPHYSIOLOGY AND TREATMENT OF SPINAL CORD INJURY

2002 • 349 citations

Revisiting the essential role of oxygen in wound healing

2003 • 348 citations

Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays

2003 • 296 citations

Interferon γ-Inducible Protein-10 (IP-10), a Member of the C-X-C Chemokine Family, Is an Inhibitor of Angiogenesis

1995 • 293 citations

A Therapeutic Vaccine Approach to Stimulate Axon Regeneration in the Adult Mammalian Spinal Cord

1999 • 289 citations

Gene profiling in spinal cord injury shows role of cell cycle in neuronal death

2003 • 272 citations

Biology of Dermal Wound Repair

1993 • 266 citations

Neuroprotective autoimmunity: Naturally occurring CD4 ⁺ CD25 ⁺ regulatory T cells suppress the ability to withstand injury to the central nervous system

2002 • 261 citations

The Essential Involvement of Cross-Talk between IFN-γ and TGF-β in the Skin Wound-Healing Process

2004 • 253 citations

Concept of autoimmunity following spinal cord injury: Possible roles for T lymphocytes in the traumatized central nervous system

1996 • 248 citations

Characterizing white matter with magnetization transfer andT2

1999 • 248 citations

The Role of Drug Transporters at the Blood-Brain Barrier

2003 • 231 citations

GLIOSIS FOLLOWING CNS INJURY: THE ANATOMY OF ASTROCYTIC SCARS AND THEIR INFLUENCES ON AXONAL ELONGATION

1986 • 231 citations

Targeting the host inflammatory response in traumatic spinal cord injury

2002 • 221 citations

Temporal progression of angiogenesis and basal lamina deposition after contusive spinal cord injury in the adult rat

2002 • 202 citations

Cellular transplantation strategies for spinal cord injury and translational neurobiology

2004 • 201 citations

The Role of Hydrogen Peroxide in Endothelial Proliferative Responses

2002 • 194 citations

Pathological CNS Autoimmune Disease Triggered by Traumatic Spinal Cord Injury: Implications for Autoimmune Vaccine Therapy

2002 • 191 citations

Modulation of tight junction structure and function by cytokines

2000 • 180 citations

Hemorrhage and edema in acute spinal cord compression: demonstration by MR imaging.

1986 • 172 citations

Cleavage of the Matricellular Protein SPARC by Matrix Metalloproteinase 3 Produces Polypeptides That Influence Angiogenesis

2003 • 169 citations

Tumor Necrosis Factor-α Causes Accumulation of a Ubiquitinated Form of Hypoxia Inducible Factor-1α through a Nuclear Factor-κB-Dependent Pathway

2003 • 168 citations

Is multicomponent T₂ a good measure of myelin content in peripheral nerve?

2003 • 167 citations

Inflammatory mediators in wound healing

2003 • 167 citations

Oxygen deprivation induced cell death: an update.

2002 • 165 citations

Increase of interleukin-1β mRNA and protein in the spinal cord following experimental traumatic injury in the rat

1997 • 160 citations

Interferon-γ Interferes with Transforming Growth Factor-β Signaling through Direct Interaction of YB-1 with Smad3

2003 • 157 citations

Neuronophagia by Leukocytes in Experimental Spinal Cord Injury

1983 • 153 citations

New Vascular Tissue Rapidly Replaces Neural Parenchyma and Vessels Destroyed by a Contusion Injury to the Rat Spinal Cord

2002 • 151 citations

Gene expression profiling of acute spinal cord injury reveals spreading inflammatory signals and neuron loss

2001 • 150 citations

Cytokine activity contributes to induction of inflammatory cytokine mRNAs in spinal cord following contusion

2002 • 148 citations

GeneChip^® analysis after acute spinal cord injury in rat

2001 • 148 citations

Chapter 23 The extracellular matrix in axon regeneration

2002 • 148 citations

Differential gene expression by endothelial cells in distinct angiogenic states

2000 • 139 citations

Strain and Model Differences in Behavioral Outcomes after Spinal Cord Injury in Rat

2001 • 134 citations

Passive or Active Immunization with Myelin Basic Protein Impairs Neurological Function and Exacerbates Neuropathology after Spinal Cord Injury in Rats

2004 • 133 citations

Expression of TGFβ2 but Not TGFβ1 Correlates with the Deposition of Scar Tissue in the Lesioned Spinal Cord

2002 • 131 citations

Overview and General Considerations of Wound Repair

1998 • 129 citations

Spinal cord injury-induced inflammation: A dual-edged sword

2000 • 129 citations

Transforming growth factor-ß1 and basic fibroblast growth factor in the injured CNS

1993 • 126 citations

Posttraumatic Hypothermia Reduces Polymorphonuclear Leukocyte Accumulation Following Spinal Cord Injury in Rats

2000 • 124 citations

The Macrophage in Acute Neural Injury: Changes in Cell Numbers Over time and Levels of Cytokine Production in Mammalian Central and Peripheral Nervous Systems

2000 • 122 citations

Nogo on the Go

2002 • 119 citations

TNF-alpha stimulation of fibroblast proliferation. Dependence on platelet-derived growth factor (PDGF) secretion and alteration of PDGF receptor expression.

1995 • 119 citations

New insights into mechanisms of fibrosis in immune renal injury

2003 • 118 citations

Regeneration

2003 • 117 citations

Leukotriene B₄ Release and Polymorphonuclear Cell Infiltration in Spinal Cord Injury

1990 • 110 citations

Altered Acidic and Basic Fibroblast Growth Factor Expression Following Spinal Cord Injury

1993 • 106 citations

DNA microarray analysis of the contused spinal cord: Effect of NMDA receptor inhibition

2002 • 105 citations

Theoretical models of wound healing: past successes and future challenges

2002 • 100 citations

The evolution of regeneration: Adaptive or inherent?

1992 • 97 citations

The athymic nude rat: an animal experimental model to reveal novel aspects of innate immune responses?

2001 • 97 citations

Patterns of Gene Expression Reveal a Temporally Orchestrated Wound Healing Response in the Injured Spinal Cord

2004 • 96 citations

Multiexponential T₂ relaxation in degenerating peripheral nerve

1996 • 93 citations

Intact Aggrecan and Fragments Generated by Both Aggrecanse and Metalloproteinase-Like Activities Are Present in the Developing and Adult Rat Spinal Cord and Their Relative Abundance Is Altered by Injury

2001 • 90 citations

Transcriptome Analysis Reveals a Role of Interferon-γ in Human Neointima Formation

2001 • 89 citations

Iron-induced lipid peroxidation in spinal cord: Protection with mannitol and methylprednisolone

1985 • 86 citations

Forelimb motor performance following cervical spinal cord contusion injury in the rat

1992 • 83 citations

The collagenous lesion scar--an obstacle for axonal regeneration in brain and spinal cord injury.

2001 • 79 citations

Analysis of gene expression following spinal cord injury in rat using complementary DNA microarray

2002 • 78 citations

Dynamic contrast‐enhanced MRI of experimental spinal cord injury: In vivo serial studies

2001 • 78 citations

Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice

2002 • 76 citations

The Injured Spinal Cord: Imaging, Histopathologic, Clinical Correlates, and Basic Science Approaches to Enhancing Neural Function After Spinal Cord Injury

1996 • 71 citations

Neurosurgery : the scientific basis of clinical practice

1992 • 70 citations

Quantitative Assessment of Respiratory Function Following Contusion Injury of the Cervical Spinal Cord

1998 • 69 citations

Tumor Necrosis Factor‐α Induces Neuronal Death by Silencing Survival Signals Generated by the Type I Insulin‐Like Growth Factor Receptor

2000 • 66 citations

Bone Morphogenetic Protein 4 Mediates Apoptosis of Capillary Endothelial Cells during Rat Pupillary Membrane Regression

2003 • 62 citations

Fischer (F-344) rats have different morphology, sensorimotor and locomotor abilities compared to Lewis, Long–Evans, Sprague–Dawley and Wistar rats

2003 • 61 citations

Vascular smooth muscle cell growth‐promoting factor/F‐spondin inhibits angiogenesis via the blockade of integrin αvβ3 on vascular endothelial cells

2001 • 58 citations

Wound-healing trajectories

2003 • 58 citations

Retrograde Regulation in the CNS

2004 • 57 citations

Platelet Aggregation in Experimental Spinal Cord Injury

1979 • 53 citations

Screening anti-inflammatory compounds in injured spinal cord with microarrays: a comparison of bioinformatics analysis approaches

2004 • 26 citations

Chapter 29 T cell-based therapeutic vaccination for spinal cord injury

2002 • 26 citations

Keeping Promises: Translating Basic Research Into New Spinal Cord Injury Therapies

2004 • 26 citations

Collagens and the Reestablishment of Dermal Integrity

1988 • 22 citations

The Commonality of Cutaneous Wound Repair and Lung Injury

1991 • 17 citations

Augmented Binding and Activation of Latent Transforming Growth Factor-β by a Tryptic Fragment of Latency Associated Peptide

2002 • 13 citations

The Interplay of Secondary Degeneration and Self-Repair After Spinal Cord Injury

2003 • 6 citations

Deleted Work

1955 • 0 citations