GENERAL PRINCIPLES OF WOUND HEALING

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

COLLAGENS: Molecular Biology, Diseases, and Potentials for Therapy

1995 • 1,599 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 1,508 citations

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

1975 • 1,445 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

1985 • 1,110 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

Activated macrophages induce vascular proliferation

1977 • 818 citations

Platelet-derived growth factor in chemotactic for fibroblasts.

1982 • 744 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Fibrogenic cytokines: the role of immune mediators in the development of scar tissue

1991 • 607 citations

The Matrix Metalloproteinases and Their Inhibitors

1992 • 604 citations

An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.

1986 • 593 citations

The molecular and cellular biology of wound repair

1996 • 562 citations

Wound Healing: Biochemical and Clinical Aspects

1993 • 535 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

Distribution of Fibronectin During Wound Healing in Vivo

1981 • 474 citations

Biochemical characteristics and biological significance of the genetically-distinct collagens

1976 • 468 citations

The Healing of Rat Skin Wounds

1965 • 465 citations

Sequential appearance of fibronectin and collagen in experimental granulation tissue.

1980 • 449 citations

Wound Healing: Biochemical & Clinical Aspects

1992 • 447 citations

Wound repair in the context of extracellular matrix

1994 • 435 citations

Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

1994 • 431 citations

The role of extracellular matrix in postinflammatory wound healing and fibrosis

1994 • 415 citations

The neutrophilic leukocyte in wound repair

1972 • 400 citations

The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts.

1987 • 399 citations

In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes.

1996 • 381 citations

Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells

1991 • 379 citations

Biochemical analysis of acute and chronic wound environments

1996 • 356 citations

Fibroblast adhesion to fibrinogen and fibrin substrata: Requirement for cold-insoluble globulin (plasma fibronectin)

1980 • 355 citations

Temporal expression of different pathways of 1-arginine metabolism in healing wounds.

1990 • 351 citations

Evidence of Fibroblast Heterogeneity and the Role of Fibroblast Subpopulations in Fibrosis

1994 • 343 citations

Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.

1993 • 319 citations

Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice.

1990 • 307 citations

Collagenase Production by Endotoxin-Activated Macrophages

1974 • 303 citations

Activity of a Macrophage Factor in Collagen Formation by Silica

1967 • 293 citations

Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

1990 • 288 citations

Diabetes impairs the late inflammatory response to wound healing

1991 • 284 citations

Nitric Oxide Regulates Wound Healing

1996 • 282 citations

Biochemical analysis of wound fluid from nonhealing and healing chronic leg ulcers

1996 • 281 citations

Recombinant basic fibroblast growth factor accelerates wound healing

1988 • 269 citations

Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth

1991 • 260 citations

Reorganization of polymerized actin: a possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels.

1986 • 256 citations

Neutrophil-endothelial cell interactions. Modulation of neutrophil adhesiveness induced by complement fragments C5a and C5a des arg and formyl-methionyl-leucyl-phenylalanine in vitro.

1984 • 248 citations

Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.

1988 • 241 citations

Transforming growth factor-beta (TGFβ) is chemotactic for human monocytes and induces their expression of angiogenic activity

1988 • 233 citations

Collagen Fiber Formation in Repair Tissue: Development of Strength and Toughness

1985 • 229 citations

The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts.

1994 • 222 citations

Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts.

1991 • 220 citations

Isolation of a nonmitogenic angiogenesis factor from wound fluid.

1982 • 219 citations

Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization.

1993 • 217 citations

Quantitation of Collagen Types I and III during Wound Healing in Rat Skin

1979 • 212 citations

Determination of Endogenous Cytokines in Chronic Wounds

1994 • 210 citations

Studies on the biology of collagen during wound healing. I. Rate of collagen synthesis and deposition in cutaneous wounds of the rat.

1968 • 206 citations

Cytokine Mediators of Immunity and Inflammation

1993 • 204 citations

Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair.

1989 • 199 citations

The Treatment of Hypertrophic Scar, Keloid and Scar Contracture by Triamcinolone Acetonide

1966 • 195 citations

Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes.

1992 • 186 citations

Collagen polymorphism in experimental granulation tissue

1975 • 183 citations

Prevention of Earlobe Keloid Recurrence with Postoperative Corticosteroid Injections Versus Radiation Therapy A Randomized, Prospective Study and Review of the Literature

1996 • 183 citations

Wound closure: evidence of cooperation between fibroblasts and collagen matrix

1988 • 178 citations

Gelatinase activity during wound healing

1994 • 177 citations

Collagen types in early phases of wound healing in children.

1978 • 175 citations

Vitamin A and wound healing

1986 • 162 citations

Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and tumor necrosis factor-alpha and beta

1989 • 158 citations

Human keratinocytes are a major source of cutaneous platelet-derived growth factor.

1993 • 149 citations

Subcutaneous perfusion of tumor necrosis factor induces local proliferation of fibroblasts, capillaries, and epidermal cells, or massive tissue necrosis.

1990 • 147 citations

The Influence of Fibrin Stabilizing Factor on the Growth of Fibroblats in vitro and Wound Healing

1961 • 139 citations

Intralesional Interferon Gamma Treatment for Keloids and Hypertrophic Scars

1990 • 138 citations

Characterization of Wound Cytokines in the Sponge Matrix Model

1989 • 137 citations

Collagenase Expression Is Rapidly Induced in Wound-Edge Keratinocytes After Acute Injury in Human Skin, Persists During Healing, and Stops at Re-Epithelialization

1995 • 136 citations

Regulation of wound healing from a connective tissue perspective

1996 • 134 citations

Cytokine production in a model of wound healing: The appearance of MIP-1, MIP-2, cachectin/TNF and IL-I

1990 • 133 citations

Current concepts in soft connective tissue wound healing

1983 • 129 citations

Wound Healing

1976 • 126 citations

Macrophage activation by culture in an anoxic environment.

1995 • 120 citations

TNF-alpha stimulation of fibroblast proliferation. Dependence on platelet-derived growth factor (PDGF) secretion and alteration of PDGF receptor expression.

1995 • 119 citations

Wound Collagen Accumulation in Obese Hyperglycemic Mice

1986 • 118 citations

Inter- and intra-site heterogeneity in the expression of fetal-like phenotypic characteristics by gingival fibroblasts: potential significance for wound healing

1994 • 118 citations

Effect of enhanced macrophage function on early wound healing.

1988 • 118 citations

The alpha1beta1 integrin is expressed during neointima formation in rat arteries and mediates collagen matrix reorganization.

1996 • 116 citations

Differential stimulation of collagenase and chemotactic activity in fibroblasts derived from rat wound repair tissue and human skin by growth factors

1989 • 114 citations

Basic Fibroblast Growth Factor in the Early Human Burn Wound

1994 • 106 citations

Fibroblast prostaglandin E2 synthesis. Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products.

1983 • 106 citations

Metalloproteinase Activation Cascade After Burn Injury: A Longitudinal Analysis of the Human Wound Environment

1994 • 104 citations

Differential Proliferation of Rat Lung Fibroblasts Induced by the Platelet-derived Growth Factor-AA, -AB, and -BB Isoforms Secreted by Rat Alveolar Macrophages

1991 • 103 citations

Differential Regulation of Collagen, Glycosaminoglycan, Fibronectin, and Collagenase Activity Production in Cultured Human Adult Dermal Fibroblasts by Interleukin 1-Alpha and Beta and Tumor Necrosis Factor-Alpha and Beta.

1989 • 94 citations

Biochemical and Clinical Aspects

1975 • 94 citations

Rate of Chondroitin Sulfate Formation in Wound Healing

1967 • 94 citations

Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes

1987 • 93 citations

Two peptides related to platelet-derived growth factor are present in human wound fluid.

1989 • 91 citations

Acidic Fibroblast Growth Factor Accelerates Dermal Wound Healing in Diabetic Mice

1995 • 89 citations

Lower cytokine release by fetal porcine platelets: A possible explanation for reduced inflammation after fetal wounding

1996 • 85 citations

Regulation of human lung fibroblast alpha 1(I) procollagen gene expression by tumor necrosis factor alpha, interleukin-1 beta, and prostaglandin E2

1993 • 79 citations

Modulation of α‐smooth muscle actin expression in fibroblasts by transforming growth factor‐β isoforms: an in vivo and in vitro study

1996 • 79 citations

Measurement of collagen biosynthesis during wound healing

1975 • 79 citations

Localization of collagen α1(I) gene expression during wound healing by in situ hybridization

1989 • 78 citations

Macrophage Involvement in Wound Repair, Remodeling, and Fibrosis

1988 • 77 citations

PDGF and FGF reverse the healing impairment in protein-malnourished diabetic mice.

1993 • 76 citations

The effects of platelet‐derived transforming growth factor β on normal human diploid gingival fibroblasts

1986 • 75 citations

Fibronectin fragments stimulate tumor necrosis factor secretion by human monocytes

1992 • 74 citations

Cell adhesion to extracellular matrix regulates the life cycle of integrins.

1995 • 73 citations

Expression of Type VI Collagen mRNA During Wound Healing

1993 • 72 citations

Interaction of Immune and Connective Tissue Cells: I. The Effect of Lymphokines and Monokines on Fibroblast Growth

1990 • 67 citations

The wound environment as a regulator of fibroblast phenotype

1991 • 65 citations

Changes in growth factor levels in human wound fluid.

1992 • 65 citations

Growth Factors

1993 • 61 citations

Nitric Oxide Synthase Pathway May Mediate Human Natural Killer Cell Cytotoxicity

1995 • 58 citations

Basal and stimulated formation and release of L-arginine-derived nitrogen oxides from cultured endothelial cells.

1990 • 57 citations

The effect of PGE2 on the activation of quiescent lung fibroblasts

1987 • 55 citations

Fibroblast heterogeneity in the healing wound

1995 • 54 citations

Regulation of alpha 1 (I)-collagen gene expression in response to cell adhesion in Swiss 3T3 fibroblasts.

1990 • 52 citations

Heterogeneous spontaneous and interleukin-4–induced nitric oxide production by human monocytes

1994 • 51 citations

Effects of Platelet-Derived Growth Factor Isoforms on Human Lung Fibroblast Proliferation and Procollagen Gene Expression

1993 • 47 citations

Macrophage activation for intracellular killing as induced by calcium ionophore. Correlation with biologic and biochemical events.

1991 • 41 citations

Comparative growth dynamics and morphology between cultured myofibroblasts from granulating wounds and dermal fibroblasts.

1984 • 40 citations

Platelet-derived growth factor (PDGF) receptor alpha-subunit mutant and reconstituted cell lines demonstrate that transforming growth factor-beta can be mitogenic through PDGF A-chain-dependent and -independent pathways.

1994 • 38 citations

Immunohistochemical localization of basic fibroblast growth factor in wound healing sites of mouse skin

1992 • 37 citations

Effect of cell-cell and cell-matrix interactions on the response of fibroblasts to epidermal growth factor in vitro. Expression of collagen type I, collagenase, stromelysin and tissue inhibitor of metalloproteinases

1992 • 35 citations

Untitled

1996 • 35 citations

Diminished Responsiveness of Senescent Normal Human Fibroblasts to TNF-Dependent Proliferation and Interleukin Production is Not Due to Its Effect on the Receptors or on the Activation of a Nuclear Factor NF- B

1995 • 34 citations

Localization of Collagen alpha1(I) Gene Expression During Wound Healing by In Situ Hybridization.

1989 • 33 citations

Rat plasma fibronectin contains two distinct chemotactic domains for fibroblastic cells

1991 • 32 citations

Surgical Basic Science

1993 • 32 citations

Primary culture of adult mouse lung fibroblasts in serum-free medium: Responses to growth factors

1991 • 31 citations

Fibroblast growth factors in operative wound healing.

1995 • 31 citations

Induction of collagen synthesis in rats by transplantation of allogenic macrophages.

1976 • 31 citations

Chemoattractants and growth factors

1992 • 28 citations

Wound collagen accumulation in obese hyperglycemic mice

1986 • 27 citations

Modulatory activities of wound fluid on fibroblast proliferation and collagen synthesis

1990 • 26 citations

Basic fibroblast growth factor accelerates gastric mucosal restoration in vitro by promoting mesenchymal cell migration and proliferation

1995 • 22 citations

Tumor Necrosis Factor-α Increased the Integrin α2β1 Expression and Cell Attachment to Type I Collagen in Human Dermal Fibroblasts

1993 • 20 citations

Effects of Growth Factors on Mucosal Scar Fibroblasts in Culture — a Possible Role of Growth Factors in Scar Formation

1991 • 20 citations

The wounded dermal equivalent offers a simplified model for studying wound repair in vitro

1993 • 19 citations

The temporal change in amino acid concentration within wound fluid--a putative rationale.

1991 • 18 citations

Studies on Collagen Synthesis in the Mature Dermal Scar in the Guinea Pig

1975 • 17 citations

Potentiation of Balb/3T3 fibroblast proliferative response by interleukin-1 and epidermal growth factor

1988 • 16 citations

Molecular properties and diseases of collagens.

1995 • 14 citations

Prostaglandin E2 antagonizes gingival fibroblast proliferation stimulated by interleukin-1β

1993 • 10 citations

Combined action of interferons and transforming growth factor beta on the proliferation of human fibroblasts.

1991 • 7 citations

Altered growth factor sensitivity in EL2 rat fibroblasts: influence of this biological characteristic on cell growth.

1989 • 6 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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