GLIOSIS FOLLOWING CNS INJURY: THE ANATOMY OF ASTROCYTIC SCARS AND THEIR INFLUENCES ON AXONAL ELONGATION

Degeneration and Regeneration of the Nervous System.

1929 • 2,924 citations

Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult Rats

1981 • 1,679 citations

The fine structure of the nervous system: The neurons and supporting cells

1976 • 1,334 citations

An acidic protein isolated from fibrous astrocytes

1971 • 1,192 citations

Laminin promotes neuritic regeneration from cultured peripheral and central neurons.

1983 • 726 citations

Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes

1985 • 714 citations

Nerve regeneration in silicone chambers: Influence of gap length and of distal stump components

1982 • 612 citations

Neuronal regulation of astroglial morphology and proliferation in vitro.

1985 • 605 citations

Expression of apolipoprotein E during nerve degeneration and regeneration.

1986 • 563 citations

Nerve growth factor, laminin, and fibronectin promote neurite growth in human fetal sensory ganglia cultures

1982 • 541 citations

Neural grafting in the mammalian CNS

1985 • 536 citations

Transition between immature radial glia and mature astrocytes studied with a monoclonal antibody to vimentin

1984 • 536 citations

Differential inhibition of neurone–neurone, neurone–astrocyte and astrocyte–astrocyte adhesion by L1, L2 and N-CAM antibodies

1985 • 497 citations

Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site

1982 • 477 citations

THE ASTROGLIAL RESPONSE TO STABBING. IMMUNOFLUORESCENCE STUDIES WITH ANTIBODIES TO ASTROCYTE‐SPECIFIC PROTEIN (GFA) IN MAMMALIAN AND SUBMAMMALIAN VERTEBRATES

1976 • 473 citations

Spinal Cord Reconstruction

1983 • 437 citations

Extensive elongation of axons from rat brain into peripheral nerve grafts

1982 • 436 citations

Glia are a unique substrate for the in vitro growth of central nervous system neurons

1984 • 425 citations

Intracerebral Neural Implants: Neuronal Replacement and Reconstruction of Damaged Circuitries

1984 • 416 citations

Fibrillary astrocytes proliferate in response to brain injury

1979 • 399 citations

Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retina of adult rats

1985 • 390 citations

Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity

1983 • 389 citations

Laminin is produced by early rat astrocytes in primary culture.

1983 • 389 citations

Guidance of optic axons in vivo by a preformed adhesive pathway on neuroepithelial endfeet

1984 • 386 citations

Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurones

1979 • 378 citations

Regeneration of monoaminergic and cholinergic neurons in the mammalian central nervous system

1979 • 374 citations

Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve I. Cell proliferation

1976 • 364 citations

Observations on the astrocyte response to a cerebral stab wound in adult rats

1985 • 354 citations

Regeneration of long spinal axons in the rat

1984 • 354 citations

Tropism in nerve regeneration in vivo. Attraction of regenerating axons by diffusible factors derived from cells in distal nerve stumps of transected peripheral nerves

1982 • 340 citations

Trophic Mechanisms in the Peripheral Nervous System

1978 • 326 citations

An electron microscopic analysis of gliogenesis in rat optic nerves

1969 • 326 citations

Influences of the Glial Environment on the Elongation of Axons After Injury: Transplantation Studies in Adult Rodents

1981 • 318 citations

Laminin is induced in astrocytes of adult brain by injury.

1984 • 315 citations

Regeneration in the Central Nervous System

1956 • 309 citations

Laminin-immunoreactive glia distinguish regenerative adult CNS systems from non-regenerative ones.

1985 • 298 citations

Deposition of Scar Tissue in the Central Nervous System

1983 • 285 citations

Cell Biology of Synaptic Plasticity

1984 • 275 citations

The proliferation of astrocytes around a needle wound in the rat brain.

1970 • 271 citations

Proteins of the nervous system

1966 • 266 citations

Reformation of the severed septohippocampal cholinergic pathway in the adult rat by transplanted septal neurons

1977 • 264 citations

HYPOTHESES CONCERNED WITH AXONAL REGENERATION IN THE MAMMALIAN NERVOUS SYSTEM

1979 • 264 citations

Intraspinal transplantation of embyronic spinal cord tissue in neonatal and adult rats

1986 • 262 citations

ARRAYS OF PARTICLES IN FREEZE-FRACTURED ASTROCYTIC MEMBRANES

1974 • 257 citations

Guidance of neurite outgrowth by pathways of substratum‐adsorbed laminin

1985 • 252 citations

Regeneration in The Vertebrate Central Nervous System

1964 • 249 citations

The glial cells in the nerve fiber layer of the rat olfactory bulb

1984 • 238 citations

Nerve growth activities in rat peripheral nerve

1982 • 235 citations

Electron microscopic studies of wallerian degeneration in rat optic nerves. I. The multipotential glia

1970 • 234 citations

Preferential outgrowth of central nervous system neurites on astrocytes and Schwann cells as compared with nonglial cells in vitro.

1985 • 232 citations

Comparison of nerve cell and nerve cell plus Schwann cell cultures, with particular emphasis on basal lamina and collagen formation.

1980 • 229 citations

Development and growth of axonal sprouts from noradrenaline and 5-hydroxytryptamine neurones in the rat spinal cord

1971 • 218 citations

Textbook of neuropathology

1986 • 215 citations

Peripheral nerve autografts to the rat spinal cord: Studies with axonal tracing methods

1982 • 214 citations

Electron microscopic studies of Wallerian degeneration in rat optic nerves. II. Astrocytes, oligodendrocytes and adventitial cells

1970 • 208 citations

Is reactive gliosis a property of a distinct subpopulation of astrocytes?

1986 • 206 citations

Changing Concepts of the Nervous System

1982 • 200 citations

Regeneration of Axons in the Vertebrate Central Nervous System

1956 • 200 citations

Proliferative and migratory activity of glial cells in the partially deafferented hippocampus

1979 • 197 citations

The cellular reaction to wallerian degeneration in the central nervous system of the cat

1969 • 190 citations

Glial cells express N-CAM/D2-CAM-like polypeptides in vitro

1985 • 186 citations

Axonal Elongation in Peripheral and Central Nervous System Transplants

1982 • 186 citations

Degenerative patterns in the ventral cochlear nucleus of the rat after primary deafferentation. An ultrastructural study

1973 • 178 citations

Correlation of axonal regeneration and slow component B in two branches of a single axon

1983 • 178 citations

Fine structural relationships between neurites and radial glial processes in developing mouse spinal cord

1974 • 178 citations

Hypertrophy and redistribution of astrocytes in the deafferented dentate gyrus

1976 • 175 citations

Functional reinnervation of rat hippocampus by locus coeruleus implants

1979 • 172 citations

The possibility of structural and functional restitution after spinal cord injury. A review

1977 • 168 citations

Neuroglial reactions secondary to wallerian degeneration in the optic nerve of the postnatal rat: Ultrastructural and quantitative study

1977 • 166 citations

The role of oligodendroglia and astroglia in wallerian degeneration of the optic nerve

1973 • 160 citations

Astrocytes secrete basal lamina after hemisection of rat spinal cord

1985 • 160 citations

Astrocyte cell lineage. V. Similarity of astrocytes that form in the presence of dBcAMP in cultures to reactive astrocytes in vivo

1984 • 157 citations

Laminin as a substrate for retinal axons in vitro

1984 • 152 citations

Glial fibrillary acidic protein in cryogenic lesions of the rat brain

1981 • 151 citations

Degeneration and Regeneration of Neurosecretory Systems

1973 • 149 citations

A Specific 37,000-Dalton Protein That Accumulates in Regenerating but Not in Nonregenerating Mammalian Nerves

1985 • 144 citations

Inhibition of formation of a glial barrier as a means of permitting a peripheral nerve to grow into the brain

1952 • 144 citations

Posttraumatic Peripheral Nerve Regeneration: Experimental Basis and Clinical Implications

1981 • 143 citations

Comparative study of the glial fibrillary acidic protein in vertebrates by PAP immunohistochemistry

1983 • 142 citations

Specific projections of retina transplanted to rat brain

1980 • 142 citations

Biosynthesis of type IV collagen by cultured rat Schwann cells.

1983 • 137 citations

Filament proteins in rat optic nerves undergoing Wallerian degeneration: Localization of vimentin, the fibroblastic 100-Å filament protein, in normal and reactive astrocytes

1981 • 137 citations

The Reactive Astrocyte

1981 • 136 citations

AXONAL REGENERATION IN THE DORSAL COLUMNS OF THE SPINAL CORD OF ADULT RATS. AN ELECTRON MICROSCOPIC STUDY.

1964 • 131 citations

The fine structure of pulse labeled (³H‐thymidine cells) in degenerating rat optic nerve

1975 • 129 citations

Plasticity of the corticospinal tract following midthoracic spinal injury in the postnatal rat

1983 • 129 citations

Regeneration and remyelination ofXenopus tadpole optic nerve fibres following transection or crush

1974 • 129 citations

An autoradiographic study of cellular proliferation in degenerating rat optic nerve

1971 • 129 citations

Axonal regeneration after crush injury of rat central nervous system fibres innervating peripheral nerve grafts

1985 • 128 citations

Glial fibrillary acidic protein in the retina of the developing albino rat: An immunoperoxidase study of paraffin‐embedded tissue

1981 • 128 citations

Reinnervation of the denervated adult spinal cord of rats by intraspinal transplants of embryonic brain stem neurons

1983 • 122 citations

Membrane Structure in Mammalian Astrocytes: A Review of Freeze-Fracture Studies on Adult, Developing, Reactive and Cultured Astrocytes

1981 • 121 citations

Astroglial reaction in the gray matter of lumbar segments after midthoracic transection of the adult rat spinal cord

1981 • 119 citations

Regeneration of monoamine-containing axons in the developing and adult spinal cord of the rat following intraspinal 6-OH-dopamine injections or transections

1971 • 119 citations

Assemblies of particles in the cell membranes of developing, mature and reactive astrocytes

1979 • 116 citations

Repair and Regeneration of the Nervous System

1982 • 112 citations

Development of embryonic spinal cord transplants in the rat

1983 • 111 citations

Reaction of oligodendrocytes and astrocytes to trauma and implantation. A combined autoradiographic and immunohistochemical study.

1985 • 110 citations

Differences between adult and neonatal rats in their astroglial response to spinal injury

1984 • 110 citations

Nerve, organ, and tissue regeneration : research perspectives

1983 • 109 citations

Ensheathment and myelination of regenerating PNS fibres by transplanted optic nerve glia

1978 • 106 citations

An ultrastructural and immunocytochemical study of astrocytic differentiation in vitro

1982 • 104 citations

The re-innervation of olfactory glomeruli following transection of primary olfactory axons in the central or peripheral nervous system.

1983 • 103 citations

Neuroglial response to sciatic neurectomy. II. Electron microscopy,

1973 • 101 citations

Reinnervation of the ventral root L7 from ventral horn neurons following intramedullary axotomy in adult cats

1983 • 100 citations

Three morphologically distinct types of interface develop between adult host and fetal brain transplants: Implications for scar formation in the adult central nervous system

1986 • 100 citations

Monoaminergic reinnervation of the transected spinal cord by homologous fetal brain grafts

1977 • 100 citations

Neurite guidance by non-neuronal cells in culture: preferential outgrowth of peripheral neurites on glial as compared to nonglial cell surfaces

1985 • 97 citations

Autoradiographic investigations of glial proliferation in the brain of adult mice. II. Cycle time and mode of proliferation of neuroglia and endothelial cells

1975 • 96 citations

Vascular and astrocytic reactions during establishment of hippocampal transplants in adult host brain

1984 • 95 citations

Intracisternal neurotoxins and monoamine neurons innervating the spinal cord: Acute and chronic effects on cell and axon counts and nerve terminal densities

1977 • 94 citations

THE MECHANISM OF CICATRICIAL CONTRACTION IN THE BRAIN

1927 • 93 citations

The problem of neuronal regeneration in the central nervous system: II. The insertion of peripheral nerve stumps into the brain.

1943 • 92 citations

Neuroglial response to sciatic neurectomy. I. Light microscopy and autoradiography,

1973 • 90 citations

Cicatrix formation in rat cerebral cortex as revealed by electron microscopy.

1959 • 88 citations

Regulation of glial fibrillary acidic protein (GFAP) expression in CNS development and in pathological states

1985 • 83 citations

Development of fetal retina, tectum, and cortex transplanted to the superior colliculus of adult rats

1983 • 78 citations

Studies on the control of myelinogenesis. 3. Signalling of oligodendrocyte myelination by regenerating peripheral axons

1979 • 76 citations

The relationship of glial fibrillary acidic protein to the shape, motility, and differentiation of human astrocytoma cells

1982 • 76 citations

Astrocyte cell lineage. III. The morphology of differentiating mouse astrocytes in colony culture

1984 • 76 citations

Essentiality of a specific cellular terrain for growth of axons into a spinal cord lesion

1985 • 75 citations

NEURAL TISSUE GRAFTS AND REPAIR OF THE INJURED SPINAL CORD

1985 • 75 citations

Penetration of grafted astrocytic scars by regenerating optic nerve axons in xenopus tadpoles

1979 • 75 citations

Injured neurons in the olfactory bulb of the adult rat grow axons along grafts of peripheral nerve

1985 • 72 citations

Ineffectiveness of enzyme therapy on regeneration in the transected spinal cord of the rat

1980 • 71 citations

Interactions between intraspinal Schwann cells and the cellular constituents normally occuring in the spinal cord: An ultrastructural study in the irradiated rat

1983 • 71 citations

Reinnervation of peripheral nerve segments implanted into the rat central nervous system

1980 • 70 citations

Origin of the connective tissue scar in the transected rat spinal cord

1981 • 70 citations

The distribution of orthogonal arrays and their relationship to intercellular junctions in neuroglia of the freeze-fractured hypothalamo-neurohypophysial system

1981 • 69 citations

Astrocytic membrane morphology: Differences between mammalian and amphibian astrocytes after axotomy

1984 • 69 citations

Cell proliferation in injured spinal cord. An electron microscopic study

1973 • 67 citations

Reinnervation of the olfactory bulb after section of the olfactory nerve in monkey (Saimiri sciureus)

1980 • 66 citations

Expression of GFAP immunoreactivity during development of long fiber tracts in the rat CNS

1983 • 65 citations

Efferent fibers from transplanted cerebral cortex of rats

1979 • 65 citations

Regional organization of astrocytic membranes in cerebellar cortex

1982 • 63 citations

AN IMMUNOLOGICAL APPROACH TO REGENERATION IN THE CENTRAL NERVOUS SYSTEM

1974 • 62 citations

Cellular reactions to small cerebral stab wounds in the rat frontal lobe

1976 • 62 citations

Effects of sciatic nerve crush on the L7 spinal roots and dorsal root ganglia in kittens

1983 • 61 citations

Axonal interactions with connective tissue and glial substrata during optic nerve regeneration in Xenopus larvae and adults

1982 • 60 citations

Effect of glial-ependymal scar and Teflon arrest on the regenerative capacity of goldfish spinal cord

1967 • 59 citations

Regenerating dorsal roots and the nerve entry zone: An immunofluorescence study with neurofilament and laminin antisera

1984 • 58 citations

Synthesis by Schwann cells of basal lamina and membrane-associated heparan sulfate proteoglycans.

1985 • 57 citations

SPINAL CORD TRANSECTION: A QUANTITATIVE ANALYSIS OF ELEMENTS OF THE CONNECTIVE TISSUE MATRIX FORMED WITHIN THE SITE OF LESION FOLLOWING ADMINISTRATION OF PIROMEN, CYTOXAN OR TRYPSIN

1979 • 57 citations

Histopathological reactions and axonal regeneration in the transected spinal cord of hibernating squirrels

1981 • 57 citations

Glial fibrillary acidic protein in regenerating teleost spinal cord.

1984 • 56 citations

Pituicytes and the regenerative properties of neurosecretory and other axons in the rat.

1971 • 55 citations

AXON SPROUTING INTO SEGMENTS OF RAT SPINAL CORD ADJACENT TO THE SITE OF A PREVIOUS TRANSECTION

1979 • 54 citations

Regeneration of dorsal root fibers into the adult rat spinal cord

1973 • 53 citations

Recent advances in neuropathology

1980 • 50 citations

Basal Lamina Formation by Astrocytes in Organotypic Cultures of Mouse Spinal Cord Tissue

1985 • 49 citations

Formation of synapses in the adult rat after injury: similarities and differences between a peripheral and a central nervous site

1977 • 49 citations

Hippocampal neurotrophic factor: Characterization and response to denervation

1986 • 48 citations

Repair of the mammalian spinal cord

1983 • 46 citations

Dorsal root innervation of spinal cord neurons after dorsal root implantation into the spinal cord of adult rats

1985 • 46 citations

Lack of orthogonal particle assemblies and presence of tight junctions in astrocytes of the goldfish (Carassius auratus)

1983 • 45 citations

Cell division in injured spinal cord

1968 • 44 citations

AXON REACTION AND CENTRAL NERVOUS SYSTEM REGENERATION

1983 • 43 citations

Intraspinal non‐neuronal cellular responses to peripheral nerve injury

1979 • 40 citations

Observations on the cytolemma of the olfactory receptor cell in the newt

1978 • 39 citations

The Fine Structure of Astrocytes in the Adult Staggerer

1976 • 38 citations

Substances originating from the optic nerve of neonatal rabbit induce regeneration-associated response in the injured optic nerve of adult rabbit.

1984 • 38 citations

The Role of Schwann Cells in the Repair of Glial Cell Deficits in the Spinal Cord

1986 • 37 citations

Studies of human and bovine spinal nerve roots and the outgrowth of CNS tissues into the nerve root entry zone

1979 • 36 citations

Autologous peripheral nerve grafting into murine brain as a model for studies of regeneration in the central nervous system

1983 • 35 citations

Ependymal astrocytes in the frog cerebellum

1981 • 35 citations

Glial fibrillary acidic protein in the optic nerve of the developing albino rat: An immunoperoxidase study of paraffin‐embedded tissue

1981 • 34 citations

Glial fibrillary acidic protein and induced differentiation of glia in vitro

1982 • 32 citations

Transplantation of Neurons and Sheath Cells — A Tool for the Study of Regeneration

1982 • 32 citations

Plasma membrane organization of astrocytes in elasmobranchs with special reference to the brain barrier system

1984 • 32 citations

The differentiation of glial cells and glia limitans in organ cultures of chick spinal cord

1972 • 31 citations

Neural Transplantation and Regeneration

1986 • 31 citations

Early axonal changes following lesions of the dorsal columns in rats

1974 • 31 citations

GLIAL OUTGROWTH AND CENTRAL‐TYPE MYELINATION OF REGENERATING AXONS IN SPINAL NERVE ROOTS FOLLOWING TRANSECTION AND SUTURE: LIGHT AND ELECTRON MICROSCOPIC STUDY IN THE PIG

1978 • 30 citations

Membrane structure in cultured astrocytes

1983 • 29 citations

Reactive glial protein synthesis and early disappearance of saxitoxin binding in degenerating rat optic nerve

1983 • 29 citations

The aberrant retino‐retinal projection during optic nerve regeneration in the frog. III. Effects of crushing both nerves

1981 • 29 citations

Neuritic growth maintained near the lesion site long after spinal cord transection in the newborn rat

1981 • 29 citations

Astrogliosis limits the integration of peripheral nerve grafts into the spinal cord

1983 • 27 citations

Regeneration of cauda equina fibres after transsection and end-to-end suture

1977 • 26 citations

Effect of puromycin treatment on the regeneration of hemisected and transected rat spinal cord

1978 • 25 citations

Dendrites and neuroglia following hemisection of rat spinal cord: effects of puromycin.

1975 • 25 citations

Regrowth of anastomosed ventral root nerve fibers in the dorsal root of rats

1983 • 25 citations

The regeneration of peripheral nerves inserted into the cerebral cortex and the healing of cerebral lesions

1958 • 25 citations

Reinnervation of spinal cord by cholinergic neurons.

1968 • 24 citations

An electron microscopic study of the neuroglial reaction in the hypoglossal nucleus after transection of the hypoglossal nerve

1973 • 23 citations

Visual system transplanted to the brain of rats

1985 • 22 citations

Absence of the gamma-spindle loop in the reinnervated hind leg muscles of the cat: ?Alpha-Muscle?

1976 • 22 citations

Regrowth of cholinergic and catecholaminergic neurons along a peripheral and central nervous pathway

1985 • 22 citations

Regeneration of lumbar dorsal root axons into the spinal cord of adult frogs (rana pipiens), an HRP study

1985 • 21 citations

Regeneration of cauda equina fibres after transsection and end-to-end suture

1977 • 20 citations

An electron microscopic study of the neuroglial reaction in Wallerian degeneration of the corticospinal tract

1973 • 20 citations

Effect of cytosine arabinofuranoside (AraC) on reactive gliosis in vivo. An immunohistochemical and morphometric study

1985 • 19 citations

A morphological study of glial cells in the hypoglossal nucleus of the cat during nerve regeneration

1985 • 19 citations

Evidence for orthogonal arrays of particles in the plasma membranes of olfactory and vomeronasal sensory neurons of vertebrates

1983 • 19 citations

Structural and functional regeneration in the central nervous system.

1952 • 15 citations

Tangled Masses of Regenerated Central Nerve Fibers (Non-Myelinated Central Neuromas) in the Central Nervous System

1981 • 15 citations

Regeneration of transected dorsal root ganglion cell axons into the spinal cord in adult frogs (Xenopus laevis)

1984 • 14 citations

Tropic factors in reactive mammalian central nervous system tissue

1985 • 14 citations

Heterogeneity of astrocytic membranes in the optic nerve and spinal cord of the lizard, Anolis carolinensis

1985 • 13 citations

THE ORGANIZATION OF ASTROCYTES IN ORGANOTYPIC MOUSE SPINAL CORD CULTURE: AN ELECTRON MICROSCOPE STUDY

1984 • 12 citations

Basal lamina at the site of spinal cord transection in the rat: An ultrastructural study

1984 • 12 citations

Is the architecture of astrocytic membrane crucial for axonal regeneration in the central nervous system?

1984 • 11 citations

TRANSPLANTATION OF EMBRYONIC NEURAL TISSUE TO THE TECTAL REGION OF NEWBORN RATS

1982 • 11 citations

Specialization of astrocytic membrane at glia limitans in rat optic nerve: Freeze-fracture observations

1985 • 11 citations

Reactive alterations in non-neuronal elements of the degenerating ventrobasal complex of immature and mature rats

1977 • 10 citations

Long-term survival of peripheral axons that have reinnervated the spinal cord

1984 • 8 citations

Suppression of reactive glial proliferation in the denervated dentate gyrus of the rat: effects on the pattern of acetylcholinesterase staining in the molecular layer

1983 • 5 citations