Increase of interleukin-1β mRNA and protein in the spinal cord following experimental traumatic injury in the rat

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)

1990 • 1,307 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus.

1989 • 785 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats

1995 • 572 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

Spinal cord contusion in the rat: Behavioral analysis of functional neurologic impairment☆

1985 • 382 citations

Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.

1991 • 375 citations

Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia

1992 • 336 citations

Functions and mechanisms of interleukin 1 in the brain

1991 • 325 citations

The Microglial Reaction in the Rat Dorsal Hippocampus following Transient Forebrain Ischemia

1991 • 301 citations

Gene expression and function of interleukin I, interleukin 6 and tumor necrosis factor in the brain

1994 • 288 citations

Spinal cord contusion in the rat: Morphometric analyses of alterations in the spinal cord☆

1985 • 274 citations

Spinal cord contusion in the rat: Production of graded, reproducible, injury groups☆

1985 • 247 citations

Induction of interleukin-1β mRNA after focal cerebral ischaemia in the rat

1994 • 236 citations

Interleukin-1 β and tumor necrosis factor-α synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes

1990 • 233 citations

Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.

1990 • 221 citations

Distribution and time course of protein extravasation in the rat spinal cord after contusive injury

1989 • 218 citations

Experimental brain injury induces expression of interleukin-1β mRNA in the rat brain

1995 • 217 citations

Cytokine Regulation of Neuronal Survival

1992 • 209 citations

Neurotrophic Factors in Central Nervous System Trauma

1995 • 204 citations

Expression of interleukin (IL)‐1β, IL‐6 and their respective receptors in the normal rat brain and after injury

1992 • 191 citations

Chapter 30: Astrocytic response to injury

1992 • 191 citations

Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain.

1991 • 165 citations

The Interleukin-1 Receptor Antagonist (rhIL-1ra) Protects against Cerebral Infarction in a Rat Model of Hypoxia-Ischemia

1994 • 161 citations

Regulation by Interleukin‐1 of Nerve Growth Factor Secretion and Nerve Growth Factor mRNA Expression in Rat Primary Astroglial Cultures

1991 • 153 citations

Production of tumor necrosis factor in spinal cord following traumatic injury in rats

1996 • 153 citations

Induction of interleukin-1β mRNA in adult rat brain

1991 • 136 citations

An improved general method to generate internal standards for competitive PCR.

1994 • 118 citations

Increased Basic Fibroblast Growth Factor Expression Following Contusive Spinal Cord Injury

1996 • 88 citations

Behavioral assessment of functional deficit in rats with contusive spinal cord injury

1987 • 86 citations

Role of hypothalamic interleukin-6 and tumor necrosis factor-alpha in LPS fever in rat

1993 • 85 citations

Intrastriatal implantation of interleukin-1

1994 • 69 citations

Cytokine Regulation of Nerve Growth Factor‐Mediated Cholinergic Neurotrophic Activity Synthesized by Astrocytes and Fibroblasts

1992 • 68 citations

Increase in nerve growth factor-like immunoreactivity and decrease in choline acetyltransferase following contusive spinal cord injury

1991 • 67 citations

Increased basic fibroblast growth factor mRNA following contusive spinal cord injury

1994 • 66 citations

Low-dose interleukin 1 and tumor necrosis factor individually stimulate insulin release but in combination cause suppression

1994 • 64 citations

Biomechanical Analysis of Experimental Spinal Cord Injury and Functional Loss

1988 • 59 citations

Spinal Cord Contusion in the Rat: Somatosensory Evoked Potentials as a Function of Graded Injury1

1988 • 35 citations

Localization of nerve growth factor receptor mRNA in contused rat spinal cord by in situ hybridization

1991 • 25 citations