Gene profiling in spinal cord injury shows role of cell cycle in neuronal death

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

The glial scar and central nervous system repair

1999 • 1,757 citations

Spinal-cord injury

2002 • 1,607 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury

1997 • 901 citations

Proliferating cell nuclear antigen is required for DNA excision repair

1992 • 809 citations

Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation

1996 • 787 citations

A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK

1998 • 740 citations

Acute Spinal Cord Injury, Part I: Pathophysiologic Mechanisms

2001 • 703 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

1999 • 558 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Review of Current Evidence for Apoptosis After Spinal Cord Injury

2000 • 507 citations

Genomic instability in Gadd45a-deficient mice

1999 • 499 citations

Expression Profiling in the Muscular Dystrophies

2000 • 484 citations

Pathways governing G1/S transition and their response to DNA damage

2001 • 461 citations

Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury

1999 • 449 citations

Mechanisms of apoptosis by c-Myc

1999 • 430 citations

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes

2000 • 422 citations

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

1997 • 396 citations

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

1996 • 383 citations

S Phase of the Cell Cycle

1989 • 366 citations

Myc and the cell cycle

1998 • 360 citations

c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points

1999 • 319 citations

Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

1997 • 282 citations

Acute spinal cord injury. A study using physical examination and magnetic resonance imaging.

1990 • 263 citations

Myc Requires Distinct E2F Activities to Induce S Phase and Apoptosis

2001 • 253 citations

Sequential mRNA Expression for Immediate Early Genes, Cytokines, and Neurotrophins in Spinal Cord Injury

2000 • 250 citations

Fos Family Members Induce Cell Cycle Entry by Activating Cyclin D1

1998 • 241 citations

Role of Cell Cycle Regulatory Proteins in Cerebellar Granule Neuron Apoptosis

1999 • 238 citations

Neuronal apoptosis at the G1/S cell cycle checkpoint

2001 • 236 citations

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

2001 • 229 citations

Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia

2002 • 218 citations

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3

2000 • 203 citations

Role of Gadd45 in apoptosis

2000 • 187 citations

Sources of variability and effect of experimental approach on expression profiling data interpretation

2002 • 180 citations

Involvement of Myc Activity in a G₁/S-Promoting Mechanism Parallel to the pRb/E2F Pathway

2000 • 165 citations

Apoptotic and Anti-Apoptotic Mechanisms Following Spinal Cord Injury

2001 • 153 citations

Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage

2000 • 151 citations

Gene expression profiling of acute spinal cord injury reveals spreading inflammatory signals and neuron loss

2001 • 150 citations

GeneChip^® analysis after acute spinal cord injury in rat

2001 • 148 citations

Rapid Upregulation of Caspase-3 in Rat Spinal Cord after Injury: mRNA, Protein, and Cellular Localization Correlates with Apoptotic Cell Death

2000 • 141 citations

Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases

1999 • 121 citations

Involvement of p38 in Apoptosis-associated Membrane Blebbing and Nuclear Condensation

2001 • 121 citations

Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury

1994 • 120 citations

Cyclin-Dependent Kinase 4 and Cyclin D1 Are Required for Excitotoxin-Induced Neuronal Cell DeathIn Vivo

2001 • 102 citations

c-Myc Is Necessary for DNA Damage-Induced Apoptosis in the G₂ Phase of the Cell Cycle

2001 • 84 citations

Possible Involvement of Interleukin‐1 in Cyclooxygenase‐2Induction After Spinal Cord Injury in Rats

1999 • 74 citations

Molecular Strategies in CNS Injury

1995 • 74 citations

Cyclin D1 and Cdk4 Protein Induction in Motor Neurons After Transient Spinal Cord Ischemia in Rabbits

2000 • 59 citations

Involvement of CPP32/Caspase-3 in c-Myc-induced apoptosis

1998 • 58 citations

Cell cycle-related gene expression in the adult rat brain: Selective induction of cyclin G1 and p21WAF1/CIP1 in neurons following focal cerebral ischemia

1998 • 57 citations

Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis

2000 • 55 citations

Transient Global Ischemia Triggers Expression of the DNA Damage-Inducible Gene GADD45 in the Rat Brain

1998 • 54 citations

A Cell Cycle Alteration Precedes Apoptosis of Granule Cell Precursors in the weaver Mouse Cerebellum

1999 • 53 citations

Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat

2000 • 39 citations

Pathophysiology of sodium channelopathies. Studies of sodium channel expression by quantitative multiplex fluorescence polymerase chain reaction

1994 • 32 citations

Gene expression in neurotrauma

2001 • 13 citations