Regulation of Neoplastic Angiogenesis

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

Angiogenic Factors

1987 • 3,702 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

The pathogenesis of cancer metastasis

1980 • 1,750 citations

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

1977 • 1,422 citations

Clinical Cancer Research

1941 • 1,358 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy

1992 • 1,076 citations

Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

Biological Diversity in Metastatic Neoplasms: Origins and Implications

1982 • 937 citations

Chapter 1: Interferons (IFNs)

1986 • 793 citations

Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea 2

1974 • 762 citations

How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture.

1986 • 744 citations

Tumor invasion and metastasis: an imbalance of positive and negative regulation.

1991 • 711 citations

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

How Tumors Become Angiogenic

1996 • 514 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Elevated Levels of an Angiogenic Peptide, Basic Fibroblast Growth Factor, in the Urine of Patients With a Wide Spectrum of Cancers

1994 • 478 citations

Treatment of Pulmonary Hemangiomatosis with Recombinant Interferon Alfa-2a

1989 • 444 citations

Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas.

1995 • 442 citations

Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice.

1994 • 357 citations

Inhibition of Cell Motility by Interferon

1980 • 331 citations

Recombinant Alpha-2 Interferon Therapy for Kaposi's Sarcoma Associated with the Acquired Immunodeficiency Syndrome

1984 • 329 citations

Angiogenesis inhibition: A review

1994 • 324 citations

Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts.

1984 • 301 citations

Inhibition of endothelial cell proliferation by gamma-interferon.

1987 • 292 citations

?Seed and soil? revisited: mechanisms of site-specific metastasis

1982 • 276 citations

Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration.

1998 • 270 citations

Modulation of the Organ Microenvironment for Treatment of Cancer Metastasis

1995 • 244 citations

α and α Interferons and Their Receptor and Their Friends and Relations

1995 • 243 citations

Cytokine networks in solid human tumors: regulation of angiogenesis

1994 • 209 citations

Kaposi's sarcoma and the acquired immunodeficiency syndrome: treatment with high and low doses of recombinant leukocyte A interferon.

1986 • 209 citations

Autocrine β-related interferon controls c-myc suppression and growth arrest during hematopoietic cell differentiation

1986 • 206 citations

Microvascular Injury in Pathogenesis of Interferon-Induced Necrosis of Subcutaneous Tumors in Mice

1989 • 192 citations

Interferon : principles and medical applications

1992 • 154 citations

Progressive growth of infantile cutaneous hemangiomas is directly correlated with hyperplasia and angiogenesis of adjacent epidermis and inversely correlated with expression of the endogenous angiogenesis inhibitor, IFN-beta.

1999 • 145 citations

Antiproliferative Potencies of Interferons on Melanoma Cell Lines and Xenografts: Higher Efficacy of Interferon β

1992 • 144 citations

Molecular Regulation of UVB-Induced Cutaneous Angiogenesis

1998 • 141 citations

Organ site-dependent expression of basic fibroblast growth factor in human renal cell carcinoma cells.

1994 • 136 citations

Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice

1992 • 134 citations

Expression of Basic Fibroblast Growth Factor in Primary Human Renal Tumors: Correlation With Poor Survival

1993 • 132 citations

Suppression of angiogenesis, tumorigenicity, and metastasis by human prostate cancer cells engineered to produce interferon-beta.

1999 • 132 citations

Regulation of interleukin-8 expression in human melanoma cells by the organ environment.

1995 • 115 citations

Interferon Alfa-2A Therapy for Airway Hemangiomas

1994 • 108 citations

Treatment of acquired immunodeficiency syndrome--related Kaposi's sarcoma with lymphoblastoid interferon.

1985 • 101 citations

Interferon–Alpha-2a for the Treatment of Complex Hemangiomas of Infancy and Childhood

1994 • 101 citations

Amplification of the 3q26.3 Locus Is Associated with Progression to Invasive Cancer and Is a Negative Prognostic Factor in Head and Neck Squamous Cell Carcinomas

2002 • 97 citations

Injection of mice with antibody to interferon enhances the growth of transplantable murine tumors.

1983 • 94 citations

Antitumor Effects of Interferon

1989 • 87 citations

Clinicopathological observations on metastasis in man studied in patients treated with peritoneovenous shunts.

1984 • 84 citations

The antiproliferative effect of interferon and the mitogenic activity of growth factors are independent cell cycle events

1985 • 84 citations

Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density.

1996 • 76 citations

Effects of rIFN Alpha, Beta, and Gamma on the Morphology, Proliferation, and Cell Surface Antigen Expression of Human Dermal Microvascular Endothelial Cells In Vitro

1990 • 75 citations

How does interferon inhibit tumor growth?

1985 • 71 citations

Immunomodulation by interferons: recent developments.

1985 • 69 citations

Urinary basic fibroblast growth factor in patients with bladder cancer and benign prostatic hypertrophy

1995 • 67 citations

Alpha 1-interferon gene transfer into metastatic Friend leukemia cells abrogated tumorigenicity in immunocompetent mice: antitumor therapy by means of interferon-producing cells.

1993 • 65 citations

Interferon-β Prevents the Upregulation of Interleukin-8 Expression in Human Melanoma Cells

1996 • 60 citations

The role of interferon alfa in the treatment of metastatic melanoma.

1997 • 59 citations

Inhibition of wound healing in mice by local interferon alpha/beta injection.

1993 • 57 citations

Effects of Alpha and Beta Interferons on Cultured Human Keratinocytes

1985 • 53 citations

Antiproliferative effect of interferons on human prostate carcinoma cell lines

1989 • 52 citations

Regulation of Gelatinase Production in Metastatic Renal Cell Carcinoma by Organ‐specific Fibroblasts

1994 • 50 citations

Therapy of Human Ovarian Cancer by Transfection with the Murine InterferonβGene: Role of Macrophage-Inducible Nitric Oxide Synthase

1998 • 50 citations

Interferon alpha therapy of haemangiomas in newborns and infants

1991 • 48 citations

Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide.

1997 • 45 citations

Interferons and cell differentiation.

1985 • 45 citations

Expression of Interferon-β is Associated with Growth Arrest of Murine and Human Epidermal Cells

1999 • 44 citations

Interferon alpha in the treatment of AIDS‐related Kaposi's sarcoma

1991 • 40 citations

Host humoral and cellular immune mechanisms in the continued suppression of Friend erythroleukemia metastases after interferon alpha/beta treatment in mice.

1991 • 38 citations

Cell density-dependent regulation of basic fibroblast growth factor expression in human renal cell carcinoma cells.

1996 • 37 citations

Effects of nIFN β and rifn γ on growth and morphology of two human melanoma cell lines: Comparison between two‐and three‐dimensional culture

1994 • 34 citations

Interferons alpha and beta as cellular regulatory molecules.

1987 • 28 citations

Response of microvascular endothelial cells to biological response modifiers

1989 • 28 citations

Metastatic bladder cancer: Advances in treatment

1997 • 27 citations

Site-dependent expression of vascular endothelial growth factor, angiogenesis and proliferation in human gastric carcinoma

1996 • 27 citations

Tumor Microvessel Density in Breast-Cancer and its Influence On Recurrence-Free Survival - Reply

1994 • 19 citations

Inhibitory effect of human fibroblast interferon (HuIFN-β) on the growth and invasive potential of cultured human melanoma cells in vitro

1992 • 17 citations

Hypothalamic Mediation of Reduced GH Secretion in Diabetic Rats: Evidence for Reduced Cholinergic Inhibition of Somatostatin Release

1995 • 17 citations

Cell density-dependent modulation of basic fibroblast growth factor expression by human interferon-beta

1996 • 15 citations

Posttranscriptional regulation of c-myc proto-oncogene expression and growth inhibition by recombinant human interferon-? ser17 in a human colon carcinoma cell line

1992 • 15 citations

Experimental Orthotopic Models of Organ-Specific Metastasis by Human Neoplasms

1994 • 13 citations

[Tumoral vascular density in breast tumors and their effect on recurrence-free survival].

1994 • 11 citations

Host-tumor interactions in the progression of breast cancer metastasis.

1994 • 11 citations

Deleted Work

1955 • 0 citations