Interleukin-10 Is a Natural Suppressor of Cytokine Production and Inflammation in a Murine Model of Allergic Bronchopulmonary Aspergillosis

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.

1993 • 945 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

1995 • 537 citations

Interleukin-10 regulation in normal subjects and patients with asthma

1996 • 498 citations

Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis.

1995 • 354 citations

Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells.

1993 • 313 citations

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

1994 • 294 citations

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.

1995 • 283 citations

Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils.

1994 • 247 citations

Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice.

1996 • 207 citations

Immunodiagnosis of aspergillosis

1991 • 202 citations

Humoral and cell-mediated autoimmunity in allergy to Aspergillus fumigatus.

1996 • 201 citations

IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes.

1993 • 197 citations

Análisis farmacoeconómico de la pentoxifilina en úlceras venosas

2007 • 177 citations

Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor.

1993 • 170 citations

Increased interleukin-10 messenger RNA expression in atopic allergy and asthma.

1996 • 158 citations

Nebulized but not parenteral IFN-gamma decreases IgE production and normalizes airways function in a murine model of allergen sensitization.

1994 • 144 citations

Review of fungus-induced asthmatic reactions.

1995 • 135 citations

Interleukin 10 (IL-10) regulation of tumour necrosis factor alpha (TNF-alpha) from human alveolar macrophages and peripheral blood monocytes.

1996 • 134 citations

A murine model of allergic bronchopulmonary aspergillosis with elevated eosinophils and IgE.

1992 • 132 citations

Regulatory effects of intrinsic IL-10 in IgG immune complex-induced lung injury.

1995 • 113 citations

Asp f I CD4 + TH2-like T-cell lines in allergic bronchopulmonary aspergillosis

1994 • 105 citations

Regulation of Human Alveolar Macrophage Inflammatory Cytokine Production by Interleukin-10

1996 • 92 citations

Modulation by IL-10 of antigen-induced IL-5 generation, and CD4+ T lymphocyte and eosinophil infiltration into the mouse peritoneal cavity.

1996 • 90 citations

Proinflammatory cytokines in hypersensitivity pneumonitis.

1995 • 78 citations

Concomitant allergic Aspergillus sinusitis and allergic bronchopulmonary aspergillosis associated with familial occurrence of allergic bronchopulmonary aspergillosis.

1990 • 62 citations

Isolation and Characterization of a Relevant <i>Aspergillus fumigatus</i> Antigen with IgG- and IgE-Binding Activity

1988 • 52 citations

HYPERSENSITIVITY PNEUMONITIS

1992 • 46 citations

Asp f I CD4 + TH2-like T-cell lines in allergic bronchopulmonary aspergillosis

1994 • 42 citations

A Familial Occurrence of Allergic Bronchopulmonary Aspergillosis

1979 • 35 citations

Interleukin-10 decreases tumor necrosis factor alpha and beta in alloreactions induced by human lung dendritic cells and macrophages.

1995 • 35 citations

Immunopathological Response of C57BL/6 and C3H/HeN Mice to <i>Aspergillus fumigatus</i> Antigens

1990 • 28 citations

Experimental Allergic Bronchopulmonary Aspergillosis in the Mouse: Immunological and Histological Features

1994 • 26 citations

Regulation of cytokine release by alveolar macrophages treated with interleukin-4, interleukin-10, or transforming growth factor beta.

1996 • 26 citations

CD3 +, CD4+, CD8—, la— T Cells Adoptively Transfer Murine Experimental Hypersensitivity Pneumonitis

1993 • 25 citations

Analysis of IgG Subclass and IgE Response in Allergic Disease Caused by <i>Aspergillus fumigatus</i> by Immunoblotting Techniques

1994 • 23 citations

Regulation of Human Monocyte Functions by Interleukin-10

1995 • 19 citations

Effect of human lung allograft alveolar macrophages on IgG production: immunoregulatory role of interleukin-10, transforming growth factor-beta, and interleukin-6.

1995 • 11 citations

IL-10 and Human T Cells

1995 • 6 citations