Identification and functional characterization of a second chain of the interleukin-10 receptor complex

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis

1978 • 1,954 citations

Interleukin-10

1993 • 1,820 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

1992 • 1,259 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning

1994 • 658 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Genetic transfer of a functional human interferon α receptor into mouse cells: Cloning and expression of its c-DNA

1990 • 582 citations

Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.

1991 • 514 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.

1995 • 420 citations

Role of cytokines in determining T-lymphocyte function

1994 • 396 citations

IL-10: a novel cytotoxic T cell differentiation factor.

1991 • 391 citations

IL-10, a novel growth cofactor for mature and immature T cells.

1990 • 371 citations

Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

1995 • 350 citations

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

1995 • 350 citations

Expression cloning and characterization of a human IL-10 receptor.

1994 • 327 citations

Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T_H1 Cells

1995 • 292 citations

Human interleukin-10 can directly inhibit T-cell growth

1993 • 283 citations

Isolation and Characterization of the Human Chromosomal Gene for Polypeptide Chain Elongation Factor-1α

1989 • 277 citations

Report of the committee on human gene mapping by recombinant DNA techniques

1984 • 274 citations

Identification and sequence of an accessory factor required for activation of the human interferon γ receptor

1994 • 266 citations

Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

1995 • 247 citations

Cloning and Expression of a Long Form of the β Subunit of the Interferon αβ Receptor That Is Required for Signaling

1995 • 241 citations

A receptor for interleukin 10 is related to interferon receptors.

1993 • 233 citations

Ligand-Induced Autoregulation of IFN-γ Receptor β Chain Expression in T Helper Cell Subsets

1995 • 219 citations

Stat3 Recruitment by Two Distinct Ligand-induced, Tyrosine-phosphorylated Docking Sites in the Interleukin-10 Receptor Intracellular Domain

1996 • 211 citations

Short-Term, High-Efficiency Expression of Transfected DNA

1984 • 166 citations

Characterization of interleukin-10 receptors on human and mouse cells.

1993 • 161 citations

Interaction between the Components of the Interferon γ Receptor Complex

1995 • 160 citations

Modifications of Vectors pEF-BOS, pcDNA1 and pcDNA3 Result in Improved Convenience and Expression

1996 • 159 citations

Structural symmetry of the extracellular domain of the Cytokine/Growth hormone/Prolactin receptor family and Interferon receptors revealed by Hydrophobic Cluster Analysis

1991 • 152 citations

Lipofection reagents prepared by a simple ethanol injection technique.

1995 • 149 citations

Ligand-Induced Assembly and Activation of the Gamma Interferon Receptor in Intact Cells

1996 • 149 citations

The Jak Kinases Differentially Associate with the α and β (Accessory Factor) Chains of the Interferon γ Receptor to Form a Functional Receptor Unit Capable of Activating STAT Transcription Factors

1995 • 143 citations

Human interleukin-10 can directly inhibit T-cell growth

1993 • 143 citations

JAK protein tyrosine kinases: their role in cytokine signalling

1994 • 125 citations

Functional Regions of the Mouse Interleukin-10 Receptor Cytoplasmic Domain

1995 • 111 citations

Switching on of the proliferation or apoptosis of activated human T lymphocytes by IFN-gamma is correlated with the differential expression of the alpha- and beta-chains of its receptor.

1996 • 107 citations

Interleukin-10 and its receptor.

1994 • 102 citations

Interleukin-3 and its receptor

1995 • 94 citations

Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain.

1995 • 93 citations

Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ

1996 • 90 citations

Identification of a novel thymocyte growth-promoting factor derived from B cell lymphomas

1990 • 88 citations

A New Member of the Cytokine Receptor Gene Family Maps on Chromosome 21 at Less Than 35 kb from IFNAR

1993 • 86 citations

Lipopolysaccharide-dependent induction of IL-10 receptor expression on murine fibroblasts.

1994 • 79 citations

Molecular weight of the functional unit of human leukocyte, fibroblast, and immune interferons.

1983 • 78 citations

Stoichiometry of interaction between interferon γ and its receptor

1992 • 76 citations

Chimeric interferon-gamma receptors demonstrate that an accessory factor required for activity interacts with the extracellular domain.

1992 • 75 citations

Characterization of Recombinant Extracellular Domain of Human Interleukin-10 Receptor

1995 • 62 citations

Identification of a yeast artificial chromosome clone encoding an accessory factor for the human interferon gamma receptor: evidence for multiple accessory factors.

1993 • 59 citations

Activation of the protein tyrosine kinase tyk2 by interferon α/β

1994 • 59 citations

Structural analysis of the human interferon gamma receptor: a small segment of the intracellular domain is specifically required for class I major histocompatibility complex antigen induction and antiviral activity.

1992 • 58 citations

Report of the Committee on Human Gene Mapping by Recombinant DNA techniques (Part 1 of 9)

1987 • 52 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 43 citations

Modulation of the expression of the IFN-gamma receptor beta-chain controls responsiveness to IFN-gamma in human peripheral blood T cells.

1996 • 40 citations

Human chromosome 21-encoded cDNA clones

1986 • 38 citations

A direct signaling pathway through tyrosine kinase activation of SH2 domain-containing transcription factors

1995 • 27 citations

Chimeric Erythropoietin-Interferon γ Receptors Reveal Differences in Functional Architecture of Intracellular Domains for Signal Transduction

1997 • 27 citations

Radiation inactivation of human gamma-interferon: cellular activation requires two dimers.

1994 • 24 citations

Nonreceptor Binding of Human Chorionic Gonadotropin (hCG): Detection of hCG or a Related Molecule Bound to Endo me trial Tissue during Pregnancy Using Labeled Monoclonal Antibodies that Bind to Exposed Epitopes on the Hormone*

1987 • 24 citations

The human interferons

1982 • 22 citations

Structure of the human CRFB4 gene: Comparison with its IFNAR neighbor

1995 • 16 citations

Deleted Work

1955 • 0 citations