Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Selective Events in T Cell Development

1994 • 486 citations

A Subset of CD4 ⁺ Thymocytes Selected by MHC Class I Molecules

1994 • 464 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family

1987 • 397 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

1987 • 348 citations

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.

1983 • 325 citations

Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells.

1985 • 305 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

Polymorphism in the α3 domain of HLA-A molecules affects binding to CD8

1989 • 247 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding

1989 • 227 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

1993 • 201 citations

Substitution at residue 227 of H–2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes

1989 • 198 citations

The T cell receptor: the α and β chains define idiotype, and antigen and MHC specificity

1985 • 198 citations

The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity.

1983 • 181 citations

Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells.

1993 • 165 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

Selection of the T cell receptor repertoire in Lpr mice.

1993 • 155 citations

An unusual lineage of alpha/beta T cells that contains autoreactive cells.

1991 • 152 citations

Development of the CD4 and CD8 lineage of T cells: instruction versus selection.

1991 • 144 citations

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA

1985 • 135 citations

Development and function of T cells in mice with a disrupted CD2 gene.

1992 • 134 citations

Helper T-cell development in the absence of CD4-p56 Ick association

1993 • 132 citations

Accessories or coreceptors?

1988 • 111 citations

Identification of early stages of T lymphocyte development in the thymus cortex and medulla.

1985 • 103 citations

Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I.

1995 • 96 citations

Functional analysis of T cell subsets from mice bearing the lpr gene.

1985 • 87 citations

Co-engagement of CD8 with the T cell receptor is required for negative selection

1991 • 85 citations

Thymic selection: two pathways to life and two to death

1994 • 83 citations

CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor.

1993 • 82 citations

Induction of MHC-restricted specificity and tolerance in the thymus

1986 • 82 citations

Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin.

1995 • 79 citations

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity

1994 • 77 citations

CD4+ murine T cells develop from CD8+ precursors in vivo

1987 • 71 citations

Demethylated CD8 Gene in CD4⁺T Cells Suggests that CD4⁺Cells Develop from CD8⁺Precursors

1988 • 68 citations

Reduced development of CD4⁻8⁻B220⁺ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules

1995 • 64 citations

Thymic Selection of Cytotoxic T Cells Independent of CD8 α-Lck Association

1993 • 63 citations

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.

1993 • 62 citations

The lack of CD8α cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8⁺ T lymphocytes

1993 • 52 citations

Expression and function of CD2 during murine thymocyt

1989 • 36 citations

Functional responsiveness in vitro and in vivo of α/β T cell receptors expressed by the B2A2 (J11d)^– subset of CD4^–8^– thymocytes

1989 • 18 citations

CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire.

1991 • 18 citations

Maturation of CD4⁻8⁻α/β TCR⁺T cells induced by CD2-stimulation in vivo and in vitro

1992 • 11 citations